Search Clinical Trials in the European Union

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161-180 of 1,743 trials

Lymphoma Treatment Study: Zanubrutinib vs. Lenalidomide

We are comparing the effectiveness of zanubrutinib combined with anti-CD20 antibodies against lenalidomide plus rituximab in patients with relapsed or refractory follicular or marginal zone lymphoma. This study aims to find out which treatment works better and is safer.

Marginal Zone LymphomaFollicular Lymphoma>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteHematologyOncology

Ovarian Cancer: NiraParib Maintenance Study

We are studying whether three cycles of chemotherapy followed by the drug niraparib is as effective as six cycles for patients with advanced ovarian cancer. This trial focuses on those who have had their tumors completely removed and are HRD-positive.

Ovarian and Fallopian Tube Cancer>2 yearsEfficacy phase (II)16-20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteOncology

Solid Tumors: AZD5335 Treatment Study

We are investigating the safety and effectiveness of AZD5335, both alone and with other treatments, for people with solid tumors. This study will help us understand how the drug works in the body.

Platinum-resistant Recurrent Ovarian CancerPlatinum-sensitive Recurrent Ovarian CancerLung Adenocarcinoma>2 yearsSafety phase (I)Oncology

Acute Myeloblastic Leukemia: Daratumumab with Chemotherapy

We are testing a new treatment combining daratumumab with chemotherapy for patients aged 60 and older with adverse risk acute myeloblastic leukemia. The goal is to see if this combination is safe and effective.

Acute Myeloblastic Leukemia>2 yearsSafety phase (I)HematologyOncology

Osteoporosis: Zoledronate After Denosumab

We are studying if zoledronate can prevent bone loss in patients with osteoporosis who have stopped denosumab treatment. This trial also looks at how this treatment affects muscle strength and insulin sensitivity.

Osteoporosis>2 yearsConfirmation phase (III)Monitoring phase (IV)Standard MedicinesInternal MedicineOtolaryngology

Nipocalimab for Pregnancies at Risk of Severe Hemolytic Disease

We are studying whether Nipocalimab can help reduce the risk of fetal anemia in pregnant individuals at risk for severe hemolytic disease of the fetus and newborn. This trial compares the treatment to a placebo to assess its effectiveness.

Hemolytic Disease of the Fetus and Newborn>2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteGynecology and ObstetricsInfectious Diseases

Systemic Lupus Erythematosus: RO7507062 Study

We are investigating a new medication for people with systemic lupus erythematosus to see how safe it is and how the body responds to it. This study aims to gather important information for future treatments.

Systemic Lupus Erythematosus>2 yearsSafety phase (I)Internal MedicineRheumatology

Advanced Solid Tumors: TNG462 Treatment Study

We are testing a new treatment called TNG462 for patients with advanced solid tumors that have a specific genetic deletion. The study aims to evaluate its safety and effectiveness, both alone and with another medication.

Advanced or Metastatic Solid Tumors with MTAP Deletion>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementOncology

Diffuse Large B-Cell Lymphoma: Zilovertamab Vedotin Study

We are studying a new treatment, Zilovertamab Vedotin, combined with standard care for patients with relapsed or refractory diffuse large B-cell lymphoma. The aim is to evaluate its safety and effectiveness compared to current therapies.

Diffuse Large B-Cell Lymphoma>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboInvestigational MedicinesHematologyOncology

Solid Tumors: SKB264 with Pembrolizumab

We are investigating whether the combination of SKB264 and pembrolizumab is safe and effective for people with selected solid tumors. This study will also explore how the body handles the new drug and its effects on the immune system.

Ovarian CancerCervical CancerUrothelial Carcinoma>2 yearsEfficacy phase (II)Post-Trial Drug AccessInvestigational MedicinesCost ReimbursementOncology

Perianal Fistulas: Regenerative Cell Therapy Study

We are evaluating a new treatment combining surgery and regenerative cell therapy for people with complex perianal fistulas. The goal is to see if this approach improves healing outcomes.

Perianal Fistula>2 yearsSafety phase (I)Efficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesGastroenterology

Non-Hodgkin Lymphoma: GLPG5101 Treatment Study

We are evaluating a new treatment called GLPG5101 for patients with relapsed or refractory B-cell non-Hodgkin lymphoma. The study aims to understand its safety and effectiveness compared to existing options.

Relapsed/Refractory B-cell Non-Hodgkin Lymphoma>2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesCost ReimbursementOncology

Relapsing Multiple Sclerosis: Rituximab vs. Ocrelizumab

We are studying whether rituximab is as effective as ocrelizumab for treating relapsing MS. This trial is for patients who are starting anti-CD20 therapy.

Multiple Sclerosis>2 yearsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementInternal MedicineNeurology

Relapsed/Refractory AML: Venetoclax and Decitabine Therapy

We are studying a new combination treatment for patients with relapsed or refractory acute myeloid leukemia. The aim is to see if this therapy can help achieve remission and improve safety and recovery outcomes.

Acute Myeloid Leukemia>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesHematologyOncology

IMC-F106C for Advanced PRAME-Positive Cancers

We are studying a new treatment called IMC-F106C for individuals with advanced PRAME-positive cancers. The trial aims to assess its safety and effectiveness, both alone and with other cancer therapies.

Urothelial CarcinomaNon-Small Cell Lung CancerOvarian Carcinoma>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementOncology

Vulvar Carcinoma: Chemoradiation vs. Neoadjuvant Chemotherapy

We are comparing two treatment approaches for locally advanced vulvar carcinoma to see which is more effective and safe. We also want to understand how these treatments impact quality of life and the influence of HPV status.

LAVC (Locally Advanced Vulvar Cancer)>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesGynecology and ObstetricsOncology

Advanced Ovarian Cancer: New Chemotherapy Approach

We are investigating a combined chemotherapy treatment for patients with advanced ovarian cancer after surgery. The study aims to assess its safety, effectiveness, and impact on quality of life.

Ovarian Cancer>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGynecology and ObstetricsOncology

Preeclampsia Intervention 4: Metformin for Preterm Preeclampsia

We are studying whether daily metformin can help prolong pregnancy in women with preterm preeclampsia. We also want to see if it improves outcomes for newborns, like increasing birth weight and reducing time in neonatal care.

Preeclampsia>2 yearsConfirmation phase (III)Standard MedicinesGynecology and ObstetricsInternal Medicine

Head and Neck Cancer: New Imaging Technique

We are testing a new near-infrared imaging method to help surgeons detect remaining cancer cells during surgery. This study aims to improve the accuracy of tumor removal and preserve healthy tissue.

Head and Neck Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesOncologyOtolaryngology

Rituximab for Amyotrophic Lateral Sclerosis (ALS)

We are studying whether adding Rituximab to standard treatment can slow symptom progression in ALS patients. The trial also monitors safety and various health indicators.

Sporadic Amyotrophic Lateral Sclerosis>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesNeurology