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1941-1960 of 3,900 trials

Fanconi Anemia: Afatinib for Advanced Squamous Cell Carcinoma

We are studying whether Afatinib can help patients with Fanconi anemia who have advanced squamous cell carcinoma in the head and neck. The trial will assess its effectiveness and safety compared to current treatment options.

Advanced Squamous Cell Carcinoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

dTap Booster Vaccination for Health Care Workers

We are studying the immune response of health care workers to a dTap booster vaccine for pertussis, diphtheria, and tetanus. This helps us understand how well the vaccine boosts their immunity.

Diphtheria, Tetanus, and Pertussis Immunization1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

HPV Vaccine: PANHPVAX

We are testing a new vaccine aimed at generating an immune response against HPV in healthy volunteers. The study will help us understand its safety and how well it is tolerated.

Healthy Volunteers for HPV VaccinationSafety phase (I)Infectious DiseasesOncology

Chronic Myeloid Leukemia: Olverembatinib Study

We are testing a new drug, Olverembatinib, for patients with Chronic Phase Chronic Myeloid Leukemia. The study aims to see if it works better than the current treatment, Bosutinib, especially for those with a specific mutation.

Chronic Myeloid Leukemia1-2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteHematologyOncology

Breast Cancer: Alisertib with Hormone Therapy

We are studying how well alisertib works with hormone therapy for patients with recurrent or metastatic hormone receptor positive, HER2 negative breast cancer. Our goal is to find the best dose and assess safety and effectiveness.

Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer>2 yearsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteGynecology and ObstetricsOncology

Advanced Cancer: BI 1703880 with Ezabenlimab

We are testing how well different doses of BI 1703880 work with ezabenlimab in people with advanced solid tumors. This study aims to see how well these treatments are tolerated.

Advanced Solid Tumours>2 yearsSafety phase (I)Oncology

Posaconazole for Fungal Infection Prevention in Stem Cell Transplant Patients

We are studying whether posaconazole can effectively prevent fungal infections in patients receiving stem cell transplants. This research aims to understand how well the medication works and its impact on patient recovery.

Healthy Participants>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyInfectious Diseases

Diabetic Ketoacidosis: Comparing Ringer Lactate and Saline

We are studying whether Ringer Lactate is more effective than isotonic saline in treating severe diabetic ketoacidosis in ICU patients. This may help improve treatment outcomes for those affected.

Diabetic Ketoacidosis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesEndocrinologyInternal Medicine

Fanconi Anaemia: Gene Therapy Study

We are evaluating the long-term safety and effects of a gene therapy using modified cells in patients with Fanconi Anaemia Subtype A. This study aims to understand how well the treatment works and its impact on blood health over time.

Fanconi's AnemiaSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesPartially RemoteHematologyInternal Medicine

HIV Research: Topiramate Treatment

We are investigating whether topiramate can help activate hidden HIV in people on antiretroviral therapy. The study also examines the safety of this medication and how various factors may influence its effects.

HIV-1 Infection≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteInfectious Diseases

Advanced Solid Tumors: ART0380 Oral Treatment

We are studying the safety and effectiveness of the oral medication ART0380 for patients with advanced or metastatic solid tumors. This includes testing it alone and in combination with other drugs to see how well it works.

Advanced or Metastatic Solid TumoursSafety phase (I)Efficacy phase (II)11-15 visitsNo PlaceboInvestigational MedicinesOncology

Rheumatoid Arthritis: Abatacept and Daratumumab Treatment

We are studying a combination of two medications to see if it is safe and effective for people with rheumatoid arthritis who have specific antibodies. This research aims to explore new ways to manage autoimmunity in these patients.

Rheumatoid Arthritis6-12 monthsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesInternal MedicineRheumatology

Advanced Cancer: IO102-IO103 with Pembrolizumab

We are studying a new treatment combination for patients with metastatic non-small cell lung cancer, squamous cell carcinoma of the head and neck, or metastatic urothelial bladder cancer. The goal is to evaluate its effectiveness and safety as a first-line therapy.

Metastatic Squamous Cell Carcinoma of Head and NeckMetastatic Urothelial Bladder CancerMetastatic Non-Small Cell Lung Cancer>2 yearsEfficacy phase (II)16-20 visitsNo PlaceboInvestigational MedicinesOncology

Myelofibrosis: Tasquinimod Treatment Study

We are studying tasquinimod in patients with myelofibrosis who are not responding to current treatments. The goal is to see if it can safely reduce spleen size and improve symptoms.

Myelofibrosis3-6 monthsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementHematologyOncology

RECLAIM: Treatments for Long COVID

We are studying different treatments for people suffering from long COVID to see how they improve physical and mental health. The trial will also assess specific symptoms like fatigue and cognitive difficulties.

Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)3-6 monthsConfirmation phase (III)6-10 visitsStandard MedicinesPartially RemoteInfectious DiseasesInternal Medicine

Alcohol-Related Liver Disease: GSK4532990 Study

We are investigating a new medication, GSK4532990, for adults with alcohol-related liver disease. The study aims to see if it is safe and effective compared to a placebo.

Alcoholic Liver Disease1-2 yearsEfficacy phase (II)11-15 visitsHepatologyInternal Medicine

Atrial Fibrillation After Aortic Valve Surgery: Atorvastatin Study

We are investigating whether taking atorvastatin before surgery helps reduce the risk of atrial fibrillation in patients undergoing aortic valve replacement. We also want to see how stopping statins affects complications after surgery.

Atrial Fibrillation and FlutterPatients Undergoing Surgical Aortic Valve Replacement≤3 monthsMonitoring phase (IV)Standard MedicinesCardiology

Multiple Myeloma: Selinexor with Dexamethasone and Bortezomib

We are studying different combinations of Selinexor, Dexamethasone, and Bortezomib for patients with hard-to-treat multiple myeloma. Our goal is to see how well these treatments work and how safe they are.

Multiple MyelomaRelapsed/Refractory Multiple MyelomaPenta-Refractory Multiple Myeloma3-6 monthsEfficacy phase (II)No PlaceboInvestigational MedicinesHematologyOncology

Locally-Advanced Rectal Cancer: Tailored Treatment Study

We are studying a personalized treatment plan for patients with locally-advanced rectal cancer who respond well to initial chemotherapy. The goal is to see if this approach maintains effective surgery outcomes while reducing treatment intensity.

Rectal Cancer>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesOncology

Alzheimer's Disease: Understanding Tau Spread and Language Function

We are studying how tau protein spreads in the brain during different stages of Alzheimer's disease and its impact on language abilities. This research may help us understand cognitive changes in patients.

Early Alzheimer's Disease>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesNeurologyPsychiatry