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1961-1980 of 3,900 trials

B-Cell Lymphoma: KITE-363 and KITE-753 Study

We are investigating the safety and dosing of two new drugs for individuals with relapsed or refractory B-cell lymphoma. This study aims to gather important information to improve treatment options.

B-cell Lymphoma RefractorySafety phase (I)Oncology

Sodium Thiosulfate Injections for Ectopic Calcifications

We are studying whether injections of sodium thiosulfate can help reduce calcifications and ossifications in patients with certain autoimmune conditions. This trial will also look at the treatment's safety and its impact on pain and quality of life.

Ectopic Calcification and Ossification>2 yearsEfficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesCost ReimbursementDermatologyRheumatology

Esophageal Adenocarcinoma: Metformin Treatment

We are studying whether metformin can enhance the immune response in patients with esophageal adenocarcinoma receiving chemoradiotherapy. This research may help improve treatment effectiveness and patient outcomes.

Oesophageal Adenocarcinoma3-6 monthsEfficacy phase (II)No PlaceboStandard MedicinesEndocrinologyOncology

Daratumumab for Very High-Risk T-Cell Acute Lymphoblastic Leukemia

We are studying whether adding daratumumab to standard treatment helps adults with very high-risk T-ALL achieve better disease control. This trial will also assess the safety and effectiveness of this combination therapy.

Very High-Risk T-Lineage Acute Lymphoblastic Leukemia>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Hodgkin's Lymphoma: Atezolizumab and BEGEV Treatment

We are studying a new combination treatment for patients with relapsed or refractory Hodgkin's lymphoma to see if it helps improve response rates before stem-cell transplantation. This trial will also evaluate the safety and tolerability of this treatment approach.

Hodgkin's Lymphoma>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Mantle Cell Lymphoma: Loncastuximab Tesirine Treatment

We are studying whether loncastuximab tesirine can improve outcomes for patients with relapsed or refractory mantle cell lymphoma after immunochemotherapy. The trial also looks at the safety of this treatment and its effectiveness in reducing disease presence.

Mantle Cell LymphomaEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Plasmablastic Lymphoma: Daratumumab with Bortezomib and Dexamethasone

We are studying a combination of daratumumab, bortezomib, and dexamethasone for patients with relapsed or refractory plasmablastic lymphoma. The goal is to see if this treatment improves outcomes for those who cannot undergo stem cell transplantation.

Relapsed or Refractory Plasmablastic Lymphoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Prostate Cancer: PF-06821497 with Enzalutamide

We are studying a new treatment combining PF-06821497 with enzalutamide for men with advanced prostate cancer previously treated with abiraterone. The goal is to see if this combination can improve survival and reduce tumor activity compared to standard therapies.

Castration-resistant Prostate Cancer6-12 monthsConfirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteOncologyUrology

Myelodysplastic Syndrome: Targeted Treatment After Stem Cell Transplant

We are studying a new approach to prevent relapse and improve survival in patients with myelodysplastic syndrome after stem cell transplantation. The trial focuses on those with minimal residual disease to see if personalized treatment can help.

Myelodysplastic Syndrome>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Solid Tumors: 68Ga-FAPI-46 PET-CT Imaging Study

We are testing a new imaging method to see if it can better identify issues in solid tumors when previous scans were unclear. This study aims to improve risk assessment and safety for patients with various tumor types.

Solid Tumor>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Prostate Cancer: Radium-223 and Docetaxel Study

We are exploring whether using Radium-223 followed by Docetaxel helps men with bone-only metastatic prostate cancer feel better and live longer. This study will compare the effects of these treatments on quality of life and survival.

Metastatic Castration-Resistant Prostate CancerSymptomatic Bone-Only Metastatic Castration-Resistant Prostate Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyUrology

NVDX3 Implant: Long-Term Safety Study

We are examining the long-term safety of the NVDX3 osteogenic implant made from human tissue. This study aims to ensure it is safe for patients who may need this type of treatment.

Low Grade Degenerative Lumbar SpondylolisthesisDistal Radius Fracture>2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesOrthopedics and Traumatology

Cirrhosis: Carvedilol for Prevention

We are studying whether low-dose carvedilol can help prevent complications or death in patients with asymptomatic cirrhosis. This trial focuses on individuals with specific liver conditions to see if the medication is effective and safe.

Alcoholic Cirrhosis>2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementHepatologyInternal Medicine

Myeloma Treatment: SAR446523 Injection

We are investigating a new injection for adults with relapsed or refractory myeloma. The study aims to determine its safety and effectiveness compared to current treatments.

Refractory Plasma Cell Myeloma>2 yearsSafety phase (I)HematologyOncology

Bronchiectasis: 7% Hypertonic Saline Inhalation

We are studying whether inhaling a 7% hypertonic saline solution before physiotherapy helps patients with bronchiectasis clear mucus more effectively. We’ll also look at its impact on cough, quality of life, and any side effects.

Bronchiectasis1-2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboInvestigational MedicinesInternal MedicinePulmonology

Anorexia Nervosa: Donepezil Treatment Study

We are investigating whether donepezil can help improve symptoms and support weight gain in adult women with anorexia nervosa. This study compares its effects to a placebo to understand its potential benefits.

Anorexia Nervosa3-6 monthsEfficacy phase (II)Standard MedicinesPsychiatry

Long-term Safety of Genetically Modified T Cell Therapy

We are following up with patients who received genetically modified T cells to assess their long-term safety and survival. This study aims to understand how well the treatment works and any potential risks involved.

Acute Lymphoblastic LeukemiaSystemic Lupus ErythematosusNon-Hodgkin's Lymphoma>2 yearsEfficacy phase (II)>20 visitsNo PlaceboStandard MedicinesPartially RemoteHematologyOncologyRheumatology

Multiple Sclerosis in Kids: Ofatumumab and Siponimod Study

We are comparing two new treatments, ofatumumab and siponimod, to fingolimod in children with multiple sclerosis. The study aims to see if these new options are as effective and safe for managing their condition.

Multiple Sclerosis>2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementNeurologyPediatrics

Myelofibrosis: Testing RVU120

We are studying the investigational drug RVU120 for patients with myelofibrosis to see if it helps reduce cancer symptoms and improve treatment outcomes. This trial will also assess its safety and effectiveness when used alone or with another medication.

MyelofibrosisEfficacy phase (II)No PlaceboInvestigational MedicinesHematology

Dexamethasone for Congenital Adrenal Hyperplasia in Pregnancy

We are studying whether a lower dose of dexamethasone can effectively prevent prenatal complications in female babies with congenital adrenal hyperplasia. We will also monitor the health of mothers and their children during and after pregnancy.

Congenital Adrenal HyperplasiaEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteEndocrinologyGynecology and Obstetrics