Search Clinical Trials in the European Union

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1681-1700 of 2,251 trials

Neuroblastoma: 177Lu-DOTATATE Therapy for Children

We are evaluating a new radioactive treatment for children with refractory or recurrent neuroblastoma. The study aims to find the safest dose and assess how well the treatment works.

Recurrent or Refractory Neuroblastoma≤3 monthsSafety phase (I)No PlaceboInvestigational MedicinesOncologyPediatrics

Juvenile Idiopathic Arthritis: Biosimilar vs. Original Medications

We are studying whether switching between biosimilar and original anti-TNF medications helps children with Juvenile Idiopathic Arthritis maintain disease control. The trial will evaluate safety, effectiveness, and the occurrence of side effects.

Juvenile Idiopathic Arthritis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesRheumatology

Ischemic Stroke: DOAC Intravenous Thrombolysis Trial

We are studying whether intravenous thrombolysis is more effective than standard care for patients with ischemic stroke who have recently taken direct oral anticoagulants. This research aims to improve recovery outcomes for these patients.

Acute Ischemic Stroke>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteInternal MedicineNeurology

Kidney Transplant: Belatacept vs. Anticalcineurins

We are studying whether switching from anticalcineurins to Belatacept improves blood vessel function and reduces arterial stiffness in kidney transplant patients. This may help enhance overall cardiovascular health.

Kidney Transplant>2 yearsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementNephrology

Shoulder Surgery: Benzoyl Peroxide Treatment

We are studying whether applying a 5% benzoyl peroxide gel to the skin before shoulder surgery can reduce harmful bacteria. This may help lower the risk of infections in male patients undergoing the procedure.

Cutibacterium acnes Infection in Shoulder Arthroplasty>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesDermatologyInfectious DiseasesOrthopedics and Traumatology

Meningococcal Vaccine: Immune Response Study in Transgender and Cisgender Adults

We are investigating how healthy transgender and cisgender individuals aged 18 to 50 respond to the meningococcal serogroup B vaccine. This study aims to understand potential differences in immune responses between these groups.

Healthy Volunteers6-12 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesCost ReimbursementInfectious DiseasesInternal Medicine

Chronic Spontaneous Urticaria and Hidradenitis Suppurativa: INF904 Study

We are evaluating the safety of an oral medication called INF904 for people with moderate to severe chronic spontaneous urticaria or hidradenitis suppurativa. This study will help us understand how the medication works in the body.

Chronic Spontaneous UrticariaHidradenitis Suppurativa≤3 monthsEfficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteAllergologyDermatology

Medulloblastoma Treatment: MEMMAT Trial

We are studying a combination of anti-cancer drugs for children with recurrent brain tumors. The goal is to see if this treatment improves response rates and overall survival.

Rare CNS Tumors≤3 monthsEfficacy phase (II)No PlaceboInvestigational MedicinesNeurologyOncology

Carotid Artery Disease: [18F]AlF-NOTA-octreotide PET/MRI Study

We are exploring a new imaging method to better understand carotid artery disease in patients who have had a recent stroke or TIA. This study aims to see if it can help identify those at risk for future strokes.

Carotid Artery Atherosclerosis>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteCardiologyNeurology

Polypoidal Choroidal Vasculopathy: Faricimab Injections

We are studying the effects of faricimab injections on vision improvement in Caucasian patients with polypoidal choroidal vasculopathy. The trial will also assess the treatment's safety and durability.

Polypoidal Choroidal Vasculopathy>2 yearsMonitoring phase (IV)16-20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesOphthalmology

Chronic Lymphocytic Leukemia: APG-2575 Study

We are studying a new medication, APG-2575, for patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma. The trial will evaluate its safety and effectiveness alone and with other treatments.

Chronic Lymphocytic Leukemia (CLL)1-2 yearsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesHematologyOncology

Heart Failure: Sacubitril/Valsartan Treatment

We are studying whether the medication Sacubitril/Valsartan can improve heart function in patients with transthyretin cardiac amyloidosis and heart failure. This trial will help us understand its effects on heart pumping ability.

Transthyretin Cardiac Amyloidosis>2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCardiologyInternal Medicine

Actinic Keratosis: Keramod Gel vs. Aldara Cream

We are studying whether Keramod Gel works better than Aldara Cream for treating actinic keratosis in adults. The trial will also assess safety and how well patients tolerate each treatment.

Actinic Keratosis3-6 monthsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesDermatology

Metastatic Tumors: Atezolizumab with SABR

We are studying the effects of a new combination treatment of atezolizumab and radiotherapy for patients with metastatic tumors. This trial aims to see if this approach can help improve survival rates and understand its safety.

Metastatic Tumors3-6 monthsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Colorectal Cancer: Temozolomide and Irinotecan Treatment

We are studying a combination of temozolomide and irinotecan for patients with specific colorectal cancer characteristics after standard chemotherapy. The goal is to see if this treatment helps eliminate remaining cancer cells and improves survival.

Stage II/III Colorectal Cancer>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesOncology

BRCA-related Metastatic Breast Cancer: Pembrolizumab and Carboplatin Study

We are testing a combination of Pembrolizumab and Carboplatin for patients with BRCA-related metastatic breast cancer. The goal is to see if this treatment improves response rates and safety compared to existing options.

Stage IV Breast Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Ghrelin for Acute Ischemic Stroke Treatment

We are studying whether ghrelin can improve recovery in patients with acute ischemic stroke treated with endovascular thrombectomy. The trial will also assess its effects on overall health and safety over several days.

Ischemic Stroke1-2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteCardiologyNeurology

Heart Failure: Engineered Heart Tissue Treatment

We are studying a new type of heart tissue made from stem cells for patients with severe heart failure. The goal is to see if it is safe and effective in improving heart function and related symptoms.

Acute Heart Failure>2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesCardiologyInternal Medicine

Non-Small Cell Lung Cancer: BNT327 with Chemotherapy

We are studying the safety and effectiveness of BNT327, an investigational therapy, combined with chemotherapy for patients with non-small cell lung cancer. This trial compares it to standard treatments to see which works better.

Non-small cell lung cancer>2 yearsEfficacy phase (II)Confirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementOncology

Pulmonary Hypertension: Sotatercept Study

We are investigating the safety and effects of sotatercept in individuals with pulmonary hypertension due to heart failure. This study aims to understand how well the treatment works over time.

Pulmonary Hypertension>2 yearsEfficacy phase (II)>20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementCardiologyInternal Medicine