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1941-1960 of 2,251 trials

Glioblastoma: Radiodynamic Therapy with 5-Aminolevulinic Acid

We are testing a new treatment combining radiodynamic therapy and 5-Aminolevulinic acid for patients with a first recurrence of glioblastoma. The goal is to find the highest safe dose and ensure it can be tolerated.

Recurrent Glioblastoma>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesOncology

Prostate Cancer: Short vs. Long-Term Androgen Deprivation Therapy

We are comparing short-term and long-term hormone therapy combined with radiotherapy for men with prostate cancer that has returned after surgery. The goal is to see which approach may improve survival and reduce recurrence.

Prostate Cancer1-2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncologyUrology

Severe Spasticity: Botulinum Toxin Type A Treatment

We are studying the effects and safety of a personalized dose of botulinum toxin type A for individuals with severe spasticity. This trial aims to see how well it works for managing symptoms in the upper and lower limbs.

Spasticity Due to Brain Damage1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesNeurology

Inhaled Sevoflurane for Sedation in Critically Ill Patients

We are studying whether inhaled sevoflurane improves breathing and safety in ICU patients at risk for ARDS compared to standard sedation methods. This research may help us understand better sedation options for these vulnerable patients.

Patients at Risk of Acute Respiratory Distress Syndrome>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInternal MedicineOtolaryngologyPulmonology

Labor Induction: Oxytocin vs. Prostaglandins

We are studying whether oxytocin is as safe as prostaglandins for inducing labor in women with an unfavorable cervix. This trial will help us understand the risks and benefits of both methods.

Labor Induction>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesGynecology and Obstetrics

Metastatic Colorectal Cancer: Choosing Chemotherapy

We are exploring a new approach to select between two chemotherapy options for patients with metastatic colorectal cancer. This study will help us understand how well these treatments work and their potential side effects.

MSS/pMMR Metastatic Colorectal Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Endoscopic Sleeve Gastroplasty: Impact of Proton Pump Inhibitors

We are studying how proton pump inhibitors affect the success of endoscopic sleeve gastroplasty in people seeking weight loss. We also want to learn about their effects on quality of life and metabolic health.

Obesity1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesGastroenterologyInternal Medicine

Knee Cartilage Damage: UC-MSC Treatment

We are studying a new treatment using stem cells from umbilical cord tissue for people with cartilage damage in the knee. The trial aims to evaluate the safety and effectiveness of this approach.

Knee Cartilage Defect1-2 yearsSafety phase (I)Efficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesCost ReimbursementInternal MedicineOrthopedics and Traumatology

Dexamethasone for Severe Burns

We are studying whether early treatment with dexamethasone can help reduce serious complications and death in patients with severe burns. This trial will also look at its effects on infections and recovery times.

Severe Burns3-6 monthsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementInternal MedicineOrthopedics and Traumatology

Tacrolimus Monotherapy for Elderly Kidney Transplant Recipients

We are studying whether using tacrolimus alone can reduce infection risks and improve quality of life for elderly patients after a kidney transplant. This trial compares it to the standard triple medication regimen.

Kidney Transplant Complications>2 yearsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesInternal MedicineNephrology

Pancreatic Head Cancer: Neoadjuvant Chemotherapy Study

We are exploring whether giving chemotherapy before surgery helps improve survival for patients with resectable pancreatic head cancer compared to surgery alone. This study aims to find better treatment strategies to reduce early mortality.

Resectable Pancreatic Head Cancer>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesOncology

Advanced NSCLC: Roginolisib with Dostarlimab

We are studying a new treatment combination for patients with advanced non-squamous lung cancer who have not responded to standard therapies. The trial will evaluate safety and early signs of effectiveness.

Advanced Non-Squamous Non-Small Cell Lung CancerSafety phase (I)Efficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteOncologyPulmonology

Psilocybin for Depression in Cancer Patients

We are studying whether psilocybin can quickly improve depression in people with cancer compared to ketamine and midazolam. The trial will also look at its effects on quality of life and overall well-being.

Depression Related to Cancer3-6 monthsEfficacy phase (II)No PlaceboInvestigational MedicinesOncologyPsychiatry

Lower Limb Nonunion: NVD-003 Implant Study

We are testing a new 3D bone implant for adults with nonunion fractures in the lower limb. The study aims to evaluate its safety and effectiveness in promoting healing and improving quality of life.

Recalcitrant Lower Limb Nonunion1-2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesCost ReimbursementOrthopedics and Traumatology

End-of-Life Care: Midazolam and Morphine Study

We are investigating how midazolam and morphine can help relieve pain and discomfort in elderly patients during their final days. This study aims to understand the best dosing strategies and any potential side effects.

Symptom Treatment in End-of-Life Care for Geriatric Patients1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal Medicine

Cardiac Surgery: Angiotensin II vs. Noradrenaline

We are studying whether angiotensin II can better prevent kidney injury compared to noradrenaline in patients undergoing cardiac surgery. This research may help improve kidney health outcomes after surgery.

Acute Kidney Injury>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboInvestigational MedicinesPartially RemoteCardiologyInternal MedicineNephrology

Lung Cancer Treatment: Rilvegostomig vs. Pembrolizumab

We are studying a new drug, rilvegostomig, to see if it works better than pembrolizumab for patients with PD-L1-high metastatic non-small cell lung cancer. This trial aims to understand which treatment may improve survival and quality of life.

Lung CancerConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteOncology

Metastatic Renal Cell Carcinoma: Immunotherapy and Tumor Treatment Study

We are studying how surgery and radiation affect survival and tumor growth in patients with metastatic renal cell carcinoma receiving immunotherapy. This trial aims to improve treatment strategies and quality of life for these patients.

Advanced Kidney Cancer1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOncology

Cisternal Lavage Therapy for Aneurysmal Subarachnoid Hemorrhage

We are studying a new treatment using Urokinase and Nimodipine for patients with aneurysmal subarachnoid hemorrhage. The aim is to see if this therapy improves brain function and is safe.

Aneurysmal Subarachnoid Hemorrhage≤3 monthsEfficacy phase (II)No PlaceboStandard MedicinesNeurology

Hemophilia A: Efanesoctocog Alfa Treatment Study

We are studying the long-term effects of efanesoctocog alfa on joint health in people with hemophilia A. The trial aims to see how well it prevents joint bleeds and improves quality of life.

Haemophilia A1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementHematologyOrthopedics and Traumatology