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1921-1940 of 2,120 trials

Bloodstream Infections: PipEracillin Tazobactam vs. Meropenem

We are studying whether PipEracillin Tazobactam is as effective as Meropenem for treating bloodstream infections caused by certain resistant bacteria. This trial is for patients with infections from these specific bacteria.

Bacteremia1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

Lung Cancer Treatment: Telisotuzumab Adizutecan with Osimertinib

We are studying a new combination treatment for adults with advanced EGFR-mutated non-small cell lung cancer. The goal is to see if this approach is safer and more effective than current standard treatments.

Non-Small Cell Lung Cancer6-12 monthsEfficacy phase (II)Confirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementOncology

Ulcerative Colitis: MK-7240 Treatment Study

We are studying MK-7240 to see if it helps people with moderately to severely active ulcerative colitis achieve remission. The trial will also evaluate the safety and effectiveness of this new treatment compared to a placebo.

Ulcerative Colitis1-2 yearsConfirmation phase (III)Monitoring phase (IV)16-20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementGastroenterology

Schizophrenia and Alcohol Use Disorder: Tirzepatide Study

We are investigating whether tirzepatide can help reduce alcohol consumption in individuals with schizophrenia and alcohol use disorder. This study compares tirzepatide to a placebo to assess its effects.

Schizophrenia and Alcohol Use Disorder6-12 monthsEfficacy phase (II)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteEndocrinologyPsychiatry

Prostate Cancer Treatment: Docetaxel vs. Androgen Receptor-targeted Agents

We are studying whether docetaxel is more effective than abiraterone or enzalutamide for men with advanced prostate cancer and specific negative prognostic factors. This research aims to improve treatment outcomes and quality of life.

Metastatic Castration-Resistant Prostate CancerMonitoring phase (IV)No PlaceboStandard MedicinesOncologyUrology

Liraglutide: Effects on Digestion and Hunger

We are studying how liraglutide affects digestive activity and hunger in healthy volunteers. This research may help us understand its potential benefits for managing appetite.

Obesity1-2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesEndocrinologyGastroenterology

Cholangiocarcinoma: Chemo and Immunotherapy Study

We are exploring a combination of chemotherapy and immunotherapy for patients with locally advanced cholangiocarcinoma before surgery. The study aims to see if this approach can lower the risk of cancer returning after treatment.

Cholangiocarcinoma1-2 yearsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteOncology

Critical Limb Ischemia: L-PRF Treatment Study

We are investigating the safety of a new treatment using patient-derived fibrin for individuals with critical limb ischemia. The study also looks at its potential effects on limb health and quality of life.

Critical Limb Ischemia>2 yearsSafety phase (I)No PlaceboInvestigational MedicinesCardiologyInternal Medicine

Glioblastoma: Dendritic Cell Immunotherapy Study

We are evaluating a new immune therapy for patients with glioblastoma to see if it improves survival and quality of life compared to standard treatments.

Glioblastoma>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboInvestigational MedicinesOncology

Alzheimer's Disease: The ExPlas Study on Plasma Transfusions

We are investigating whether plasma from exercise-trained donors is safe and can improve cognitive function in people with early Alzheimer's disease. This study will help us understand its effects over several years.

Early Symptomatic Phase Alzheimer's Disease>2 yearsEfficacy phase (II)11-15 visitsInvestigational MedicinesInternal MedicineNeurology

Acute Cholecystitis: Indocyanine Green in Surgery

We are testing whether indocyanine green can help reduce surgery time and improve safety during gallbladder removal in patients with acute cholecystitis. This study aims to enhance surgical outcomes and patient satisfaction.

Acute Cholecystitis>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesGastroenterologyOrthopedics and Traumatology

MOTHER Trial: Low-Dose Morphine for Cesarean Section Pain

We are studying whether adding a low dose of morphine to standard pain management helps reduce pain after a planned cesarean section. The trial also looks at the safety for both mothers and their newborns.

Planned Caesarean Section>2 yearsMonitoring phase (IV)Standard MedicinesGynecology and ObstetricsOtolaryngology

Prostate Cancer: HIFU and Hormone Therapy Study

We are testing a combination of high-intensity focused ultrasound and short-term hormone therapy for men with intermediate-risk localized prostate cancer. The goal is to see if this approach improves cancer control and maintains sexual and urinary functions.

Intermediate Risk Prostate Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesOncologyUrology

Anticoagulation Strategies for ECMO Support

We are comparing three blood-thinning medications to see which is safer and more effective for patients on ECMO. This study aims to reduce blood clots and bleeding risks during treatment.

Respiratory Failure and Insufficiency≤3 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCardiologyInternal Medicine

Metastatic Pancreatic Cancer: Valproic Acid and Simvastatin Study

We are studying whether adding valproic acid and simvastatin to standard chemotherapy improves treatment for patients with metastatic pancreatic cancer. This trial also looks at safety and quality of life for participants.

Metastatic Pancreatic CancerEfficacy phase (II)No PlaceboStandard MedicinesOncology

Apathy After Stroke: Brain Pathway Study

We are examining how cholinergic and dopaminergic systems relate to apathy in stroke patients. This study aims to understand the brain's role in apathy to improve future treatments.

ApathyStroke>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementNeurologyPsychiatry

Severe Acute Pain: ESKAPE Study on Low-Dose Ketamine

We are comparing two low-dose ketamine treatments for severe pain in the emergency department. The study looks at pain relief and any psychological effects patients may experience.

Severe Acute Pain>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOtolaryngologyPsychiatry

Colon Cancer: Chemotherapy Study for Older Adults

We are comparing two chemotherapy strategies for patients aged 70 and older who have had surgery for stage III colon cancer. The goal is to see which treatment helps prevent cancer from returning.

Colon Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Non-Small Cell Lung Cancer: New Treatment Study

We are testing new investigational treatments for patients with previously treated stage IV non-small cell lung cancer. The study aims to evaluate how well these treatments work and their safety.

Non-small Cell Lung Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Cancer Detection: 68Ga-FAPI PET/CT Imaging Study

We are studying a new imaging method for patients with unclear cancer diagnoses from standard tests. The goal is to see if this new method can provide clearer results and improve diagnosis accuracy.

Suspicion of Cancer or New Tumor Diagnosis>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology