Search Clinical Trials in the European Union

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1541-1560 of 1,694 trials

Prostate Cancer Treatment: Docetaxel vs. Androgen Receptor-targeted Agents

We are studying whether docetaxel is more effective than abiraterone or enzalutamide for men with advanced prostate cancer and specific negative prognostic factors. This research aims to improve treatment outcomes and quality of life.

Metastatic Castration-Resistant Prostate CancerMonitoring phase (IV)No PlaceboStandard MedicinesOncologyUrology

Dravet Syndrome: EPX-100 Treatment Study

We are testing a new medication, EPX-100, to see if it helps children and adults with Dravet Syndrome manage their seizures better than a placebo. This study aims to find out if this treatment can be a useful addition to their current care.

Dravet Syndrome3-6 monthsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesNeurologyPediatrics

Gastroesophageal Cancer: Sertraline with Immunochemotherapy

We are studying whether adding sertraline can enhance treatment responses in patients with advanced gastroesophageal cancer receiving immunochemotherapy. The trial also looks at safety, quality of life, and depression during treatment.

Gastroesophageal Cancer>2 yearsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesOncologyPsychiatry

Advanced Non-Small Cell Lung Cancer: H1-Antihistamine with Immunotherapy

We are studying whether adding an H1-antihistamine to immunotherapy can improve treatment response in patients with advanced non-small cell lung cancer.

Advanced Non-Small Cell Lung Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesOncologyPulmonology

Idiopathic Infertility: Metformin Treatment Study

We are investigating whether metformin can improve endometrial function in women with idiopathic infertility. This study aims to explore its effects on fertility and related biological markers.

Female Infertility3-6 monthsEfficacy phase (II)Standard MedicinesEndocrinologyGynecology and Obstetrics

Heart Failure: Empagliflozin and Dapagliflozin Study

We are investigating how two medications may improve outcomes for patients hospitalized with acute heart failure. The study looks at their effects on heart function and other health indicators.

Acute Decompensated Heart Failure>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteCardiologyInternal Medicine

Medication-Related Osteonecrosis of the Jaw: PENTO Treatment Study

We are investigating whether the PENTO treatment can help heal jaw bone exposure in patients with MRONJ. The study will also look at pain levels, nutrition, and any side effects over time.

Medication-Related Osteonecrosis of the Jaw>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesInternal MedicineOrthopedics and Traumatology

HIV-1 Reservoir Study: ITACO and ITACO-ATI

We are investigating how the HIV-1 virus behaves in patients with perinatal infections to find better treatment strategies. This study looks at the effects of temporarily stopping antiretroviral therapy and the immune responses involved.

Perinatal HIV InfectionConfirmation phase (III)No PlaceboStandard MedicinesInfectious Diseases

Metastatic Pancreatic Cancer: Valproic Acid and Simvastatin Study

We are studying whether adding valproic acid and simvastatin to standard chemotherapy improves treatment for patients with metastatic pancreatic cancer. This trial also looks at safety and quality of life for participants.

Metastatic Pancreatic CancerEfficacy phase (II)No PlaceboStandard MedicinesOncology

Erosive Esophagitis: Linaprazan Glurate vs. Lansoprazole

We are studying whether linaprazan glurate can heal erosive esophagitis in patients with GERD better than lansoprazole. This trial aims to evaluate the effectiveness and safety of the new treatment.

Erosive Esophagitis≤3 monthsConfirmation phase (III)≤5 visitsInvestigational MedicinesCost ReimbursementPartially RemoteGastroenterology

Heart Procedure: Beta Blocker Study

We are investigating how beta blockers may impact patients undergoing transcatheter aortic valve replacement. This study aims to understand their effects on recovery and outcomes.

Aortic Stenosis>2 yearsMonitoring phase (IV)Cardiology

Colon Cancer: Chemotherapy Study for Older Adults

We are comparing two chemotherapy strategies for patients aged 70 and older who have had surgery for stage III colon cancer. The goal is to see which treatment helps prevent cancer from returning.

Colon Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Kidney Transplant: SGLT2 Inhibitor Study

We are investigating whether a new oral medication can improve kidney function in non-diabetic kidney transplant recipients. The study also looks at its safety and effects on overall health compared to a placebo.

Kidney Transplant1-2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesInternal MedicineNephrology

Rheumatoid Arthritis: Prednisolone Tapering Strategies

We are studying whether a quick reduction of low-dose Prednisolone is as effective as a slower taper for newly diagnosed rheumatoid arthritis patients. The goal is to see how these approaches affect pain, function, and overall health.

Rheumatoid Arthritis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineRheumatology

Antibiotics in Children with Brain Tumors

We are studying how different antibiotics move into the cerebrospinal fluid of children with malignant brain tumors. This research may help improve treatment for infections in these patients.

Brain Tumors>2 yearsSafety phase (I)No PlaceboStandard MedicinesInfectious DiseasesOncologyPediatrics

Breast Cancer: Inavolisib Treatment Study

We are testing a new treatment using Inavolisib for patients with early-stage, PIK3CA-mutated breast cancer. The study aims to evaluate how safe and effective this treatment is for participants.

Early-Stage Breast Cancer6-12 monthsEfficacy phase (II)11-15 visitsNo PlaceboInvestigational MedicinesPartially RemoteOncology

Blood Cancers: Sonrotoclax Safety Study

We are investigating new dosing schedules for Sonrotoclax in adults with blood cancers. The study aims to understand the safety and tolerability of this treatment approach.

Chronic Lymphocytic LeukemiaSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesHematologyOncology

Dapansutrile Tablets for Acute Gout Flare

We are studying whether dapansutrile can reduce joint pain and other symptoms in people experiencing an acute gout flare. This trial compares the medication to a placebo to assess its effectiveness and safety.

Gout Flare≤3 monthsEfficacy phase (II)Confirmation phase (III)Investigational MedicinesInternal MedicineRheumatology

Multiple Sclerosis: Ozanimod Treatment Study

We are investigating how ozanimod affects inflammation in the brain and spinal cord for individuals with Multiple Sclerosis. This study aims to understand its potential benefits and any side effects.

Relapsing Multiple Sclerosis>2 yearsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesNeurology

Cushing's Disease: Silycus® Treatment Study

We are studying the effects of Silycus® on lowering cortisol levels in patients with Cushing's disease. The trial will also evaluate how well patients tolerate the treatment and its impact on their symptoms.

Cushing's Disease1-2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesEndocrinology