Search Clinical Trials in the European Union

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1261-1280 of 1,782 trials

Acute Ischemic Stroke: Mechanical Thrombectomy Study

We are studying whether adding a mechanical procedure to standard treatment helps patients with acute ischemic stroke due to large vessel blockage. The trial also examines safety and quality of life for participants.

Malignant Ischemic Stroke>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesInternal MedicineNeurology

Hodgkin Lymphoma: Chemotherapy Alone Study

We are exploring whether chemotherapy alone is effective for patients with early-stage Hodgkin Lymphoma who have a good prognosis. This study aims to improve treatment options and monitor for potential relapses.

Classical Hodgkin LymphomaEfficacy phase (II)16-20 visitsNo PlaceboStandard MedicinesPartially RemoteHematologyOncology

Hodgkin's Lymphoma: Nivolumab and Chemotherapy Study

We are studying a new treatment approach using nivolumab followed by chemotherapy for patients with Hodgkin's lymphoma that hasn't responded to previous therapy. The goal is to see if this combination improves treatment outcomes and safety.

Refractory Hodgkin LymphomaEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesHematologyOncology

Kidney Transplant: Rituximab for EBV Prevention

We are studying whether early treatment with Rituximab can help prevent EBV infections and related complications in kidney transplant recipients who are EBV negative. This research aims to improve outcomes for patients receiving organs from EBV positive donors.

Epstein-Barr Virus in Kidney Transplant Patients>2 yearsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesHematologyInfectious DiseasesNephrology

Breast Cancer: Nivolumab and Novel Immunotherapies

We are studying whether nivolumab, alone or with other treatments, can help achieve a complete response in early breast cancer patients before surgery. This trial also looks at safety and how well the treatment works.

Breast Cancer≤3 monthsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Breast Cancer Treatment: I-BCT-1 Study

We are exploring how genetic changes in breast tumors can help select the best treatment options for patients. This study includes patients with neoadjuvant and metastatic breast cancer to improve therapy outcomes.

Breast Cancer3-6 monthsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesOncology

Myelodysplastic Syndromes: Oral ASTX030 vs. Subcutaneous Azacitidine

We are studying a new oral treatment for patients with myelodysplastic syndromes, chronic myelomonocytic leukemia, or acute myeloid leukemia. The trial aims to evaluate its safety and how it compares to the standard subcutaneous treatment.

Chronic Myelomonocytic LeukaemiaAcute Myeloid LeukaemiaMyelodysplastic Syndrome>2 yearsConfirmation phase (III)11-15 visitsNo PlaceboStandard MedicinesHematology

Type 1 Diabetes: Verapamil Treatment for Children

We are studying whether oral Verapamil can help preserve insulin production in children recently diagnosed with Type 1 diabetes. The trial also looks at the safety and effectiveness of this treatment in managing blood sugar levels.

Type 1 Diabetes>2 yearsSafety phase (I)Efficacy phase (II)≤5 visitsStandard MedicinesDiabetologyEndocrinology

Exercise and Statin Use in Advanced Cancer Treatment

We are studying whether supervised exercise and atorvastatin can improve cancer treatment outcomes for patients with advanced breast, renal, ovarian, and prostate cancers. We also want to understand how these interventions affect patients' quality of life and experiences during treatment.

Metastatic Breast, Ovarian, Prostate, and Kidney Cancer≤3 monthsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementGynecology and ObstetricsOncologyUrology

Dupuytren's Contracture: Comparing Treatment Options

We are studying three different treatments for Dupuytren's contracture to see which one works best and is most cost-effective. This trial includes patients with mild to moderate cases and will track outcomes over several years.

Dupuytren's Contracture>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesDermatologyOrthopedics and Traumatology

Intravenous Iron for Mobility After Hip Fracture Surgery

We are studying whether a single dose of intravenous iron helps elderly patients recover mobility after hip fracture surgery. The trial will also assess its effects on anemia, fatigue, and quality of life.

Hip Fracture3-6 monthsMonitoring phase (IV)≤5 visitsStandard MedicinesInternal MedicineOrthopedics and Traumatology

Liver Cancer: Immunotherapy and Radioactive Treatment Study

We are studying the effects of two immunotherapy drugs combined with a special treatment for liver cancer. This trial aims to see if this combination improves survival and quality of life for patients with non-resectable liver cancer.

Non-resectable Hepatocellular Carcinoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHepatologyOncology

Advanced Breast Cancer: The p53 Trial

We are testing a chemotherapy treatment for patients with advanced breast cancer that has TP53 mutations. The goal is to see how well it works and to understand the safety and response of different mutation types.

Breast Cancer>2 yearsEfficacy phase (II)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Recurrent Grade-4 Glioma: Bortezomib and Temozolomide Study

We are studying the safety and effectiveness of combining Bortezomib with Temozolomide for patients with recurrent grade-4 glioma. This research may help improve treatment options for this challenging condition.

Malignant Glioma3-6 monthsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesOncology

Colorectal Surgery: Cefoxitin Administration Study

We are comparing two ways of giving cefoxitin to prevent infections after colorectal surgery. This study aims to find out if a continuous infusion is better than the standard method for reducing complications.

Colorectal Surgery>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesGastroenterologyInfectious DiseasesInternal MedicineOrthopedics and Traumatology

Eosinophilic Asthma: Benralizumab Treatment Study

We are studying how well benralizumab works and its safety for people with eosinophilic asthma who are not well-controlled on standard treatments. This trial compares it to increasing their current medication dose.

Eosinophilic Asthma1-2 yearsConfirmation phase (III)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteAllergologyPulmonology

Chronic Cluster Headache: Botulinum Toxin Treatment Study

We are investigating whether botulinum toxin can help people with chronic cluster headaches that haven't responded to other treatments. The study will also look at safety and how it affects headache frequency and quality of life.

Chronic Cluster Headache3-6 monthsConfirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteNeurology

Cemiplimab for High-Risk Skin Cancer

We are studying whether the immunotherapy Cemiplimab can help prevent cancer recurrence in patients with high-risk stage III/IV skin cancer who can undergo surgery.

Cutaneous Squamous Cell CarcinomaSurgically Resectable, High Risk Stage III/IV Cutaneous Squamous Cell Carcinoma1-2 yearsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesDermatologyOncology

Advanced Pancreatic Cancer: Gemcitabine and Nab-Paclitaxel Study

We are studying whether switching to a new treatment after initial chemotherapy helps patients with advanced pancreatic cancer live longer and feel better compared to continuing their current treatment.

Advanced Pancreatic Cancer≤3 monthsConfirmation phase (III)No PlaceboStandard MedicinesOncology

HPV Vaccine Study for Women with HPV 16/18

We are studying how the 9vHPV vaccine affects the infectivity of HPV in women who are positive for HPV types 16 and/or 18. The goal is to see if vaccination reduces the virus in cervical, anal, urine, vulvar, and oral samples.

Human Papillomavirus Infection>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesGynecology and ObstetricsInfectious Diseases