Search Clinical Trials in the European Union

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1381-1400 of 1,782 trials

Acute Myeloid Leukemia: Gemtuzumab Ozogamicin Study for Children

We are testing a new treatment combining gemtuzumab ozogamicin with standard chemotherapy for children with acute myeloid leukemia. The study aims to find the best dose and compare its effectiveness with current therapies.

Acute Myeloid LeukaemiaConfirmation phase (III)No PlaceboStandard MedicinesOncologyPediatrics

Acute Myeloid Leukemia: Venetoclax vs. Intensive Chemotherapy

We are studying whether venetoclax with low-dose cytarabine can improve outcomes for patients with favorable risk acute myeloid leukemia compared to intensive chemotherapy. This trial will help us understand the best treatment options for this condition.

Acute Myeloid Leukaemia3-6 monthsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Breast Cancer Treatment: Fulvestrant with Palbociclib

We are studying whether combining fulvestrant with palbociclib helps postmenopausal women with hormone receptor-positive metastatic breast cancer live longer without disease progression compared to fulvestrant alone. This trial is for women who have completed at least five years of hormonal therapy and remained disease-free for over a year, or who have newly diagnosed metastatic disease.

Metastatic Breast Cancer1-2 yearsEfficacy phase (II)Standard MedicinesOncology

ANCA-Vasculitis: Corticosteroid Dosing Study

We are investigating if taking corticosteroids twice daily helps patients with ANCA-vasculitis maintain better blood sugar levels. This study will measure glucose control using continuous monitoring.

ANCA-associated VasculitisRapid-Progressive Glomerulonephritis≤3 monthsConfirmation phase (III)Monitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesEndocrinologyRheumatology

Immunotherapy for Cutaneous Squamous Cell Carcinoma

We are studying whether immunotherapy can help patients with skin cancer achieve remission without surgery or radiation. This trial aims to assess the treatment's effectiveness and safety over time.

Skin Cancer (Cutaneous Squamous Cell Carcinoma)>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesDermatologyOncology

Immune Thrombocytopenia: Rituximab with Belimumab

We are studying whether adding belimumab to rituximab helps adults with persistent immune thrombocytopenia. This trial will compare the effects of the combination treatment to rituximab alone.

Immune Thrombocytopenia>2 yearsConfirmation phase (III)6-10 visitsStandard MedicinesHematology

Recurrent Brain Tumors in Children: Ultrasound Blood-Brain Barrier Study

We are evaluating a new ultrasound device to safely open the blood-brain barrier before chemotherapy in children with recurrent brain tumors. This study aims to see how well this method works and its effects on tumor progression.

Glioblastoma>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesNeurologyOncologyPediatrics

COPD Management: Azithromycin Based on Mucus Properties

We are studying whether prescribing azithromycin based on mucus rheology helps reduce COPD flare-ups compared to standard treatment. This trial aims to improve care for patients with chronic airway disease.

Chronic Obstructive Pulmonary Disease>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesInternal MedicinePulmonology

Metastatic Colorectal Cancer: S 95005 with Bevacizumab

We are studying a new treatment combination for patients with metastatic colorectal cancer who cannot receive intensive therapy. The goal is to see if it helps patients live longer without disease progression compared to standard treatment.

Metastatic Colorectal Cancer1-2 yearsConfirmation phase (III)No PlaceboStandard MedicinesPartially RemoteOncology

Stroke Prevention: ASPIRING Study

We are investigating if an oral antiplatelet drug can help prevent serious heart and brain events in stroke survivors. This study compares the effects of this medication to standard care without antiplatelet drugs.

Intracerebral Hemorrhage>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteCardiologyInternal MedicineNeurology

High-Risk Breast Cancer: Personalized Chemotherapy Study

We are investigating a new chemotherapy treatment for patients with high-risk, HER2-negative breast cancer to see if it improves survival rates compared to standard therapies. This trial is for individuals with specific genetic profiles, including those without known BRCA mutations.

Breast Cancer>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncology

Intensive Care: INCEPT Trial

We are studying different treatments for adults admitted to the intensive care unit to see how they affect recovery. This trial aims to improve care by understanding the best practices among clinicians.

Intensive Care>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInfectious DiseasesInternal MedicineNeurologyPulmonology

Pancreatic Cancer: Sotorasib with Chemotherapy

We are studying the safety of combining sotorasib with standard chemotherapy for patients with advanced pancreatic cancer that has a specific genetic mutation. This trial aims to see if this combination improves treatment outcomes.

Pancreatic Cancer≤3 monthsSafety phase (I)No PlaceboStandard MedicinesGastroenterologyOncology

Cryoglobulinemia Vasculitis: Belimumab Study

We are studying whether belimumab can help people with non-infectious active cryoglobulinemia vasculitis compared to a placebo. The goal is to see if it improves symptoms and overall health.

Cryoglobulinemia Vasculitis6-12 monthsEfficacy phase (II)≤5 visitsStandard MedicinesCost ReimbursementInfectious DiseasesRheumatology

Acute Demyelinating Syndromes in Children: Azathioprine vs. Rituximab

We are studying whether starting treatment immediately with azathioprine or rituximab helps children with anti-MOG antibodies better than delaying treatment until a second attack. The goal is to see which method reduces relapses and improves health outcomes.

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)>2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteNeurologyRheumatology

Kidney Biopsy: Desmopressin Safety Study

We are studying whether Desmopressin can help prevent bleeding during kidney biopsies. This trial looks at its effects on safety and recovery time for patients.

Glomerulonephritis>2 yearsConfirmation phase (III)Standard MedicinesInternal MedicineNephrology

Metastatic Thyroid Cancer: Personalized 131I Therapy

We are studying if a personalized approach to administering radioactive iodine can improve treatment outcomes for patients with metastatic thyroid cancer. This trial also looks at how genetic factors may affect treatment effectiveness.

Thyroid Cancer>2 yearsEfficacy phase (II)Standard MedicinesOncology

Fertility Preservation for Breast Cancer: Tamoxifen and Ovarian Stimulation

We are studying whether combining Tamoxifen with ovarian stimulation can help women with breast cancer collect healthy eggs before chemotherapy. This may support their chances of having children in the future.

Breast CancerEfficacy phase (II)No PlaceboStandard MedicinesGynecology and ObstetricsOncology

Oxytocin for Children with Autism and Intellectual Disabilities

We are studying whether oxytocin can safely support educational measures for children aged 6 to 12 with autism and intellectual disabilities. This trial will help us understand its feasibility and safety in managing challenging behaviors.

Autism Spectrum Disorder and Intellectual Disability>2 yearsEfficacy phase (II)Confirmation phase (III)Standard MedicinesPediatricsPsychiatry

Prucalopride for Refractory Gastro-Esophageal Reflux Disease

We are testing a new medication for patients with GERD who still have symptoms despite taking standard treatments. The goal is to see if this drug can improve their reflux symptoms.

Gastro-esophageal Reflux Disease (GERD)≤3 monthsMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteGastroenterologyInternal Medicine