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2281-2300 of 3,900 trials

Multifocal Motor Neuropathy: DNTH103 Treatment Study

We are testing a new treatment, DNTH103, for adults with multifocal motor neuropathy to see if it improves muscle strength and quality of life. The study will also check its safety compared to a placebo.

Multifocal Motor Neuropathy1-2 yearsEfficacy phase (II)>20 visitsPost-Trial Drug AccessInvestigational MedicinesPartially RemoteNeurology

Hypochondroplasia: Vosoritide Treatment Study

We are testing a new medication, vosoritide, to see if it helps children with hypochondroplasia grow taller compared to a placebo. The study aims to evaluate its effects on growth velocity and height.

Hypochondroplasia1-2 yearsConfirmation phase (III)Post-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemotePediatrics

Venous Ulcers: Stem Cell Treatment Study

We are testing a new treatment using adipose tissue stem cells for people with venous ulcers in their lower limbs. The study aims to see if this treatment helps wounds heal faster and improves quality of life.

Venous Ulcer>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesDermatologyInternal Medicine

Botulinum Toxin for Spastic Equinovarus in Stroke Patients

We are exploring how a treatment with botulinum toxin type A affects muscle and nerve properties in people who have had their first stroke. This study aims to gather insights that could improve future treatments for spastic equinovarus.

Spastic Equinovarus in Stroke Patients3-6 monthsConfirmation phase (III)Monitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesNeurologyOrthopedics and Traumatology

Surgery Fluid Study: Albumin vs. Ringer's Solution

We are comparing two fluids to see which one better supports blood volume and circulation during laparoscopic surgery. This research may help improve patient care in surgical settings.

Fluid Therapy in Laparoscopic Surgery>2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesInternal MedicineOtolaryngology

Weight Loss in HIV: Semaglutide Study

We are investigating whether the medication semaglutide can help people living with HIV and obesity lose more weight when combined with diet and exercise. The study also looks at its effects on inflammation and overall health.

HIV and Obesity6-12 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementEndocrinologyInfectious Diseases

RSV Vaccine Study for Immunocompromised Adults

We are studying how well the RSV vaccine works and its safety in immunocompromised patients aged 18 and older. This includes comparing the immune response after one and two doses of the vaccine.

Respiratory Syncytial Virus (RSV)1-2 yearsEfficacy phase (II)6-10 visitsStandard MedicinesCost ReimbursementInfectious DiseasesInternal MedicinePulmonology

Autoimmune Hemolytic Anemia: Anticoagulation Study

We are testing whether prolonged anticoagulation therapy can help prevent blood clots in patients with autoimmune hemolytic anemia. This study will also look at how well patients tolerate the treatment and the timing of any clotting events.

Autoimmune Hemolytic Anemia>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesHematologyInternal Medicine

Multiple Sclerosis: Personalized Ocrelizumab Treatment

We are studying whether a tailored dosing of ocrelizumab is as effective as the standard treatment in managing relapsing remitting multiple sclerosis. This trial aims to improve treatment personalization for better disease control.

Multiple Sclerosis>2 yearsConfirmation phase (III)Monitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteNeurology

Asthma Treatment: Tezepelumab Study

We are investigating whether tezepelumab can improve airway structure and function in patients with asthma compared to a placebo. This study will also explore its effects on lung health and asthma flare-ups.

Severe Asthma3-6 monthsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementAllergologyPulmonology

Acute Myeloid Leukemia: JNJ-89853413 Study

We are testing a new treatment for patients with relapsed or refractory acute myeloid leukemia or myelodysplastic neoplasms. The goal is to evaluate its safety and how it may help those who have not responded to other therapies.

Relapsed or Refractory Acute Myeloid LeukemiaMyelodysplastic Syndrome>2 yearsSafety phase (I)Hematology

Lanreotide and Metformin for Advanced Carcinoids

We are studying the safety of a new treatment combining Lanreotide and Metformin for patients with advanced gastrointestinal or lung carcinoids. This trial aims to understand how well this combination works and its effects on symptoms.

Advanced Progressive Gastro-Intestinal or Lung Carcinoids>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesGastroenterologyOncology

Severe Influenza: Dexamethasone vs. Placebo

We are studying whether dexamethasone can help patients with severe influenza recover better than a placebo. The trial will assess hospitalization rates, safety, and other health impacts.

H1N1 Influenza>2 yearsConfirmation phase (III)≤5 visitsInvestigational MedicinesPartially RemoteInfectious DiseasesPulmonology

Chronic Spontaneous Urticaria: Barzolvolimab Study

We are investigating whether barzolvolimab can help patients with chronic spontaneous urticaria who still experience symptoms despite antihistamine treatment. The study aims to see if it reduces itching and hives compared to a placebo.

Chronic Spontaneous Urticaria1-2 yearsConfirmation phase (III)≤5 visitsInvestigational MedicinesCost ReimbursementAllergologyDermatology

Axial Spondyloarthritis: NSAIDs vs. Biosimilar TNF Blockers

We are comparing the effectiveness of high-dose NSAIDs and a biosimilar TNF blocker for patients with axial spondyloarthritis who haven't responded to NSAIDs. The study will also look at side effects and inflammation levels.

Axial Spondyloarthritis3-6 monthsMonitoring phase (IV)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesInternal MedicineRheumatology

Fungal Nail Infection: MOB015B Solution for Kids

We are studying a new topical solution for treating mild to moderate fungal infections of the nail in children aged 6 to 17. The goal is to see how well it works and how safe it is.

Distal Subungual Onychomycosis6-12 monthsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteDermatologyInfectious DiseasesPediatrics

Cariprazine for Adolescents with Schizophrenia

We are studying the safety and tolerability of cariprazine in adolescents aged 13 to under 18 with schizophrenia. This trial aims to see how well the medication works and its impact on health-related outcomes.

Schizophrenia>2 yearsConfirmation phase (III)>20 visitsNo PlaceboStandard MedicinesCost ReimbursementPediatricsPsychiatry

Chemotherapy for Standard Risk Adult Medulloblastomas

We are studying the effects of chemotherapy on adults diagnosed with standard risk medulloblastomas. This trial aims to understand how well this treatment works for this specific group.

MedulloblastomaEfficacy phase (II)Oncology

Vertebral Metastases: Zoledronic Acid or Denosumab with Radiation

We are studying whether adding zoledronic acid or denosumab to stereotactic radiotherapy improves treatment outcomes for patients with vertebral metastases. This trial will also look at cost-effectiveness and various health impacts.

Metastatic Bone Pain>2 yearsConfirmation phase (III)11-15 visitsNo PlaceboStandard MedicinesOncology

Hormonal Treatment for Adolescents with Gender Dysphoria

We are studying the effects of starting hormonal treatment at age 14 on the well-being of adolescents with gender dysphoria. This research aims to assess both the effectiveness and safety of the treatment as they transition into adulthood.

Gender Dysphoria>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesEndocrinologyPsychiatry