Search Clinical Trials in the European Union

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2321-2340 of 3,900 trials

Type 1 Diabetes: Diamyd® Treatment Study

We are evaluating the safety and feasibility of Diamyd® injections in young people at risk for Type 1 diabetes. This study looks at how the treatment affects their immune system and progression of the disease.

Type 1 Diabetes1-2 yearsEfficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesCost ReimbursementEndocrinologyPediatrics

Telmisartan for Portal Hypertension in Liver Disease

We are studying whether telmisartan can lower liver pressure in patients with advanced chronic liver disease and portal hypertension. This trial will also assess its safety and impact on quality of life.

Compensated Advanced Chronic Liver DiseasePortal Hypertension3-6 monthsEfficacy phase (II)6-10 visitsStandard MedicinesPartially RemoteHepatologyInternal Medicine

Norfloxacin for Portal Hypertension in Decompensated Cirrhosis

We are studying whether norfloxacin can lower portal hypertension in patients with decompensated cirrhosis. The trial also looks at its effects on liver-related complications and overall patient well-being.

Portal HypertensionDecompensated Cirrhosis3-6 monthsEfficacy phase (II)≤5 visitsStandard MedicinesGastroenterologyHepatology

Portosinusoidal Vascular Disorder: Edoxaban Study

We are studying the safety of edoxaban in patients with Portosinusoidal Vascular Disorder. The trial also explores its potential to prevent blood clots and improve quality of life.

Porto-Sinusoidal Vascular Disorder>2 yearsEfficacy phase (II)≤5 visitsStandard MedicinesPartially RemoteCardiology

Rimegepant for Migraine: Effects on Obesity

We are studying how rimegepant affects migraine-related reactions in lean and obese individuals. The goal is to understand the relationship between body composition and migraine responses.

ObesityMigraine6-12 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementEndocrinologyNeurology

Skin Cancer Treatment: The BLESS Trial

We are investigating whether reducing the dose of bleomycin in electrochemotherapy can still effectively treat skin cancers. This study aims to see if patients can benefit from less medication while achieving similar tumor response.

Skin Cancer>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesDermatologyOncology

Osteoarthritis: Safety of Lipiodol Embolization

We are assessing the safety of Lipiodol embolization for patients with hard-to-treat symptomatic osteoarthritis. This study aims to understand if this treatment can be a viable option for those not responding to conventional therapies.

Digital OsteoarthritisSafety phase (I)Internal MedicineOrthopedics and Traumatology

HIV-1 Treatment: High-Dose Antiretroviral Drugs

We are studying whether high doses of antiretroviral drugs can reduce the hidden HIV-1 reservoir in people living with HIV. This trial will also assess the safety and effects of the treatment on immune markers.

HIV Infection6-12 monthsEfficacy phase (II)No PlaceboStandard MedicinesInfectious Diseases

Behçet’s Disease Uveitis: Adalimumab vs. Tocilizumab

We are comparing two biologic treatments for severe uveitis in Behçet’s disease to see which one may better improve vision and reduce inflammation. This study will also evaluate the safety of both medications.

Severe Uveitis of Behçet’s Disease>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesOphthalmologyRheumatology

Breast Cancer: Palbociclib and Fulvestrant Combination

We are testing a combination of palbociclib and fulvestrant in women with advanced breast cancer who have not responded to prior treatments. The goal is to evaluate its effectiveness and safety for these patients.

Metastatic Breast CancerEfficacy phase (II)No PlaceboStandard MedicinesOncology

BRAF Mutated Melanoma: Encorafenib and Binimetinib with Cemiplimab and Fianlimab

We are studying a combination of treatments for patients with BRAF mutated melanoma and brain metastases. The goal is to see if this approach can help control the disease and improve survival.

Melanoma>2 yearsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteNeurologyOncology

Colorectal Cancer: PIPAC Treatment Study

We are testing a new chemotherapy method to prevent cancer spread in patients who have had surgery for high-risk colorectal cancer. This study will help us understand its effectiveness and impact on patients' quality of life.

Colorectal Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Parkinson's Disease: BIIB122 Treatment Study

We are studying the safety and effects of BIIB122 in people with LRRK2-associated Parkinson's disease. This trial aims to understand how well the treatment engages important biological pathways.

Parkinson's Disease>2 yearsEfficacy phase (II)Post-Trial Drug AccessInvestigational MedicinesNeurology

Inflammatory Bowel Disease and Rheumatoid Arthritis: Adalimumab Imaging Study

We are exploring how well a drug called adalimumab spreads in inflamed tissues using advanced imaging technology. This study aims to improve our understanding of drug distribution in patients with inflammatory bowel disease and rheumatoid arthritis.

Crohn's DiseaseSpondyloarthritisRheumatoid ArthritisSafety phase (I)GastroenterologyRheumatology

Advanced Cancer: RO7759065 and Atezolizumab Study

We are investigating a new treatment combining RO7759065 with Atezolizumab for individuals with locally advanced or metastatic cancer. The goal is to understand how safe and effective this combination is for patients.

Locally Advanced or Metastatic Solid TumorsSafety phase (I)Oncology

High-Grade Glioma: New Imaging Technique

We are testing a new method using special dyes to help surgeons better identify and remove tumors in patients with high-grade glioma. This study aims to refine how we assess tumor margins during surgery.

Glioblastoma>2 yearsSafety phase (I)NeurologyOncology

Renal Impairment: Enpatoran Study

We are investigating how kidney function impacts the way the drug Enpatoran is absorbed and used in the body. This study aims to improve treatment for patients with renal impairment.

Healthy Participants1-2 yearsSafety phase (I)Internal MedicineNephrology

Paracetamol: Brain Effects Study

We are exploring how paracetamol impacts brain function using advanced imaging techniques. This study aims to better understand its effects on pain management.

Healthy VolunteerEfficacy phase (II)Internal MedicineNeurologyOtolaryngology

Brigatinib for Pediatric and Young Adult ALK+ Cancer

We are studying the safety and effectiveness of brigatinib in children and young adults with ALK+ Anaplastic Large Cell Lymphoma and other solid tumors. This trial aims to find the best dose and understand how the drug works in these patients.

Anaplastic Large Cell Lymphoma (ALCL)Inflammatory Myofibroblastic Tumors (IMT)Other Solid Tumors>2 yearsSafety phase (I)Efficacy phase (II)>20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementOncologyPediatrics

Type 2 Diabetes: Comparing Empagliflozin, Pioglitazone, and Semaglutide

We are studying how different diabetes medications affect fat tissue function in people with type 2 diabetes. This research may help us understand which drug works best for improving health outcomes.

Type 2 Diabetes6-12 monthsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteDiabetologyEndocrinology