Search Clinical Trials in the European Union

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2361-2380 of 3,900 trials

Amlitelimab: Effects on Medication Processing

We are investigating how amlitelimab influences the way the body handles specific medications. This study aims to improve safety for patients taking multiple drugs.

Atopic Dermatitis1-2 yearsSafety phase (I)DermatologyInternal Medicine

Neurodegenerative Disorders: Tau PET Imaging Study

We are exploring a new imaging method to identify early signs of neurodegenerative diseases in at-risk individuals. The study aims to understand how tau protein relates to cognitive changes and different types of dementia.

Neurodegenerative Diseases>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesNeurology

Advanced Solid Tumors: MOMA-313 Oral Medication

We are studying an oral treatment called MOMA-313 for individuals with advanced or metastatic solid tumors. The goal is to learn more about its effects and potential benefits.

Advanced or Metastatic Solid Tumors1-2 yearsSafety phase (I)Oncology

Advanced Sarcoma: NKG2D CAR-T Cell Therapy

We are testing a new type of immune cell therapy for children and young adults with advanced sarcoma. The study aims to see if this treatment is safe and effective in reducing tumor size.

Sarcoma>2 yearsSafety phase (I)No PlaceboInvestigational MedicinesOncology

Peritonitis Treatment: Pentaglobin® Study

We are investigating whether Pentaglobin® can improve organ function and reduce the risk of death in patients recovering from peritonitis. This study looks at changes in health over time after infection control.

SepsisSeptic ShockSeptic Peritonitis3-6 monthsEfficacy phase (II)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

Crohn’s Disease and Ulcerative Colitis: Tulisokibart Study

We are studying the long-term safety and effectiveness of tulisokibart in people with Crohn’s disease or ulcerative colitis. This research aims to see how well the treatment helps manage symptoms and achieve remission.

Crohn's DiseaseUlcerative Colitis>2 yearsConfirmation phase (III)>20 visitsPost-Trial Drug AccessInvestigational MedicinesGastroenterologyInternal Medicine

Polymyalgia Rheumatica: Rituximab Study

We are investigating whether rituximab can help reduce the need for corticosteroids in people with relapsing polymyalgia rheumatica. This study compares rituximab to a placebo to assess its effectiveness.

Polymyalgia Rheumatica1-2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteGastroenterologyRheumatology

BI 3804379: Tolerance Study in Healthy Volunteers

We are testing how well different doses of BI 3804379 are tolerated by healthy people. This study aims to gather important safety information for future use in patients.

Healthy Volunteers1-2 yearsSafety phase (I)

Glioblastoma Treatment: Optune with Pembrolizumab

We are testing whether adding pembrolizumab to Optune and temozolomide improves survival for newly diagnosed glioblastoma patients compared to a placebo. This study aims to understand the effectiveness and safety of this treatment combination.

Newly Diagnosed Glioblastoma>2 yearsConfirmation phase (III)Standard MedicinesOncology

Malignant Solid Tumors: GEN1057 Treatment

We are assessing the safety and potential effectiveness of GEN1057 for individuals with malignant solid tumors. This trial aims to see how well it works compared to current treatments.

Advanced Solid Tumors>2 yearsSafety phase (I)Oncology

Gastric Bypass Surgery: Tranexamic Acid Study

We are investigating whether giving Tranexamic acid during gastric bypass surgery helps reduce bleeding in patients with morbid obesity. This could lead to safer surgical procedures.

Morbid Obesity1-2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInternal MedicineOrthopedics and Traumatology

Generalized Anxiety Disorder: MM120 Medication Study

We are testing a new oral medication, MM120, to see if it helps reduce anxiety symptoms in adults with generalized anxiety disorder. The study will also look at its effects on quality of life and sexual functioning.

Generalized Anxiety Disorder1-2 yearsConfirmation phase (III)16-20 visitsPost-Trial Drug AccessInvestigational MedicinesPartially RemotePsychiatry

BRAF Alterations in Cancer: FORE8394 Treatment Study

We are testing the drug FORE8394 in patients with advanced solid tumors or specific brain tumors that have BRAF alterations. The goal is to see if it can effectively treat these cancers.

BRAF Gene MutationEfficacy phase (II)16-20 visitsNo PlaceboInvestigational MedicinesPartially RemoteOncology

Hernia Repair: Comparing Pain Relief Techniques

We are studying whether giving a specific pain relief injection before or after hernia surgery helps reduce chronic pain and the need for pain medications. This trial is for patients undergoing open inguinal hernia mesh repair.

Chronic Pain After Hernia Surgery1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOrthopedics and Traumatology

YTB323 for Treatment-Resistant Generalized Myasthenia Gravis

We are studying the safety and effects of YTB323 in patients with treatment-resistant generalized myasthenia gravis. This research aims to understand how the drug works in the body and its potential to improve symptoms.

Myasthenia Gravis1-2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementInternal MedicineNeurology

OM85 for Preventing Respiratory Infections in Elderly Patients

We are studying whether the drug OM85 can help reduce respiratory infections in elderly individuals living in healthcare residences. This trial will also look at hospital visits and antibiotic use related to these infections.

Recurrent Respiratory Tract InfectionsMonitoring phase (IV)Standard MedicinesInternal MedicinePulmonology

COPD: Dronabinol for Breathlessness Relief

We are studying whether Dronabinol can help people with severe and very severe COPD experience less breathlessness. This trial will compare its effects against a placebo.

Chronic Obstructive Pulmonary Disease≤3 monthsEfficacy phase (II)Confirmation phase (III)Post-Trial Drug AccessStandard MedicinesInternal MedicinePulmonology

Pleural Empyema: Surgery vs. Drainage

We are studying whether surgery is more effective than drainage for treating pleural empyema. This trial will help us understand the best approach for patients with this condition.

Pleural Empyema>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicinePulmonology

Migraine Prevention: Comparing Common Medications

We are studying how well different medications prevent migraines in primary care patients. This trial aims to find out which treatment reduces migraine days and improves quality of life.

Migraine Headaches≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineNeurology

Cytoreductive Surgery: HiPRESS Study

We are testing if low-dose argipressin can reduce fluid use and improve recovery during surgery for cancer treatment. This study compares it to standard treatment to see which is better for patients.

Disseminated Cancer≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal MedicineOrthopedics and Traumatology