Search Clinical Trials in the European Union

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2341-2360 of 3,900 trials

Dupilumab for Uncontrolled Moderate to Severe Asthma

We are studying whether dupilumab can help prevent lung function decline in adults with uncontrolled moderate to severe asthma. This trial will compare its effects to a placebo over time.

AsthmaMonitoring phase (IV)6-10 visitsInvestigational MedicinesCost ReimbursementAllergologyPulmonology

Cardiovascular Disease Prevention: Personalized Statin Therapy

We are studying whether statin treatment guided by genetic risk can lower heart disease events in individuals at high risk. The trial will also look at how well patients accept this personalized approach and its effects on their health.

High Genetic Risk for Coronary Artery Disease1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteCardiologyInternal Medicine

Omalizumab Withdrawal in Severe Allergic Asthma

We are studying whether stopping Omalizumab after long-term treatment is as effective as continuing it for patients with well-controlled severe allergic asthma. This trial aims to assess asthma control and quality of life over time.

Allergic Asthma1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesAllergologyPulmonology

Pancreatic Cancer: Trametinib and Hydrochloroquine Study

We are exploring a new treatment combination for patients with metastatic pancreatic cancer to see if it helps improve survival and understand resistance to therapy. This study aims to assess safety and effectiveness while analyzing how the cancer may resist treatment.

Metastatic Pancreatic CancerEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Cortisone Treatment for Children with Facial Nerve Palsy

We are studying whether cortisone can help children with acute facial nerve paralysis recover better than a placebo. The trial will also look at safety and how the condition affects daily life.

Facial Nerve Palsy (Bell's Palsy)>2 yearsMonitoring phase (IV)Standard MedicinesNeurologyPediatrics

NK Cell Infusion for Sarcoma in Young Patients

We are testing a new immunotherapy using activated NK cells for children, adolescents, and young adults with refractory sarcomas. The goal is to evaluate its safety and effects after chemotherapy or radiotherapy.

Sarcomas>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesOncologyPediatrics

Oxytocin Treatment for Autism in Children

We are studying whether multiple doses of oxytocin can improve social symptoms in children with autism and intellectual disability. The trial also looks at other behavioral changes and stress-related measurements.

Autism Spectrum Disorder6-12 monthsConfirmation phase (III)Monitoring phase (IV)≤5 visitsStandard MedicinesCost ReimbursementPartially RemotePediatricsPsychiatry

Cancer Treatments: Impact on Speech and Quality of Life

We are studying how different cancer treatments affect speech understanding in noise and overall quality of life for patients. This research may help us understand the cognitive effects of these treatments over time.

Bladder CancerTesticular SeminomaHead and Neck Cancer≤3 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesOncologyPsychiatry

Multiple Myeloma: JNJ-87562761 Treatment

We are testing a new drug for patients with relapsed or refractory multiple myeloma. The goal is to understand its safety and how it affects the disease.

Relapsed/Refractory Multiple MyelomaSafety phase (I)HematologyOncology

CSL889 for Sickle Cell Disease: A New Treatment

We are studying the safety and effects of CSL889 in adults and adolescents with sickle cell disease during painful vaso-occlusive crises. The goal is to see if it helps speed up recovery compared to a placebo.

Sickle Cell Anemia with Crisis≤3 monthsEfficacy phase (II)Confirmation phase (III)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesPartially RemoteHematologyInternal Medicine

Colon Cancer: Dostarlimab with CAPEOX

We are studying a new treatment combining dostarlimab with CAPEOX for people with untreated Stage III colon cancer. The goal is to see if this combination is more effective and safe compared to CAPEOX alone.

Metastatic Colon CancerEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementGastroenterologyOncology

Recurrent Meningioma: [177Lu]Lu-DOTATATE Treatment Study

We are investigating whether [177Lu]Lu-DOTATATE can effectively treat recurrent meningioma compared to standard care. The study will also look at safety and quality of life for participants.

Meningioma>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesNeurologyOncology

Kidney Transplantation: Donor Modified Immune Cells

We are studying whether using specially modified immune cells can help patients tolerate their new kidney better than standard treatments. The trial also looks at the safety of this new approach in preventing infections and other complications.

Kidney Transplant>2 yearsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesInternal MedicineNephrology

Metamizole and Imatinib Interaction Study

We are investigating how the pain reliever metamizole impacts the way the body processes imatinib in healthy volunteers. This research may help improve treatment strategies for patients using these medications.

Healthy Participants6-12 monthsSafety phase (I)Internal MedicineOncology

Acute Bacterial Prostatitis: Fosfomycin vs. Cefixime

We are comparing two oral antibiotics to see which one better resolves urinary symptoms in men with acute bacterial prostatitis. The study will also look at any side effects and the effectiveness of the treatments over time.

Acute Bacterial Prostatitis3-6 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesInfectious DiseasesUrology

Multiple Sclerosis: Treatment Withdrawal Study for Older Adults

We are investigating whether stopping disease-modifying therapies is safe for people aged 55 and over with inactive relapsing-remitting multiple sclerosis. The study will help us understand its effects on relapse rates, disability, and quality of life.

Multiple Sclerosis>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementInternal MedicineNeurology

Mindfulness Training and Oxytocin for Stress Relief

We are studying whether combining oxytocin treatment with mindfulness training can better reduce stress in adults with high stress levels. This trial will measure changes in psychological distress and other related factors.

Psychological Distress≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesCost Reimbursement

Cataract Surgery: Clobetasol vs. Prednisolone in Young Children

We are studying a new eye treatment for inflammation after cataract surgery in children aged 0 to 3 years. The goal is to see if it is safer and more effective than the standard treatment.

Eye Inflammation and Pain>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesOphthalmologyPediatrics

Preventing C. difficile Infections: Oral Vancomycin for Stem Cell Transplant Patients

We are studying if oral vancomycin can help prevent infections in patients receiving allogeneic stem cell transplants. This research aims to see if it reduces the risk of Clostridium difficile infections during their hospital stay.

Clostridium Difficile InfectionPatients Hospitalized for Allogeneic Hematopoietic Stem Cell Transplantation≤3 monthsConfirmation phase (III)Standard MedicinesPartially RemoteHematologyInfectious Diseases

M9466 for Advanced Solid Tumors

We are investigating the effects of M9466, both alone and with other treatments, in patients with advanced solid tumors. This study aims to find out how well it works in this patient group.

Advanced Solid Tumors>2 yearsSafety phase (I)Oncology