Search Clinical Trials in the European Union

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221-240 of 552 trials

Corneal Endothelial Transplantation: NSAIDs vs. Steroids

We are comparing two medication regimens to see if adding NSAIDs helps reduce inflammation and cystoid macular edema after corneal endothelial transplantation. This study is for patients undergoing this specific eye surgery.

Fuchs Dystrophy>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesOphthalmology

Sufentanil for Pain Management in Abdominal Surgery

We are studying how the use of sufentanil during non-major abdominal surgery affects long-term pain and recovery. This trial looks at both immediate and chronic pain experiences in patients.

Chronic Postsurgical Pain>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal MedicineOtolaryngology

Chronic Lymphocytic Leukemia: Acalabrutinib Treatment Study

We are investigating whether acalabrutinib is safe and effective for adults with chronic lymphocytic leukemia and heart problems. This study compares it to other treatment options available for these patients.

Chronic Lymphocytic Leukaemia with Cardiac Impairment>2 yearsMonitoring phase (IV)16-20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteCardiologyHematology

Rheumatoid Arthritis: Proactive Drug Monitoring Study

We are investigating whether proactive monitoring of a TNF inhibitor helps adults with rheumatoid arthritis maintain better disease control without flare-ups compared to standard care.

Rheumatoid Arthritis1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesRheumatology

Takotsubo Syndrome: Beta-Blockers Study

We are investigating whether beta-blockers can help improve heart function in patients with Takotsubo Syndrome. This study will also look at various heart health measures and quality of life.

Takotsubo Syndrome1-2 yearsMonitoring phase (IV)6-10 visitsPartially RemoteCardiologyInternal Medicine

GSDIa: DTX401 Treatment Study

We are examining the long-term safety and pregnancy outcomes of DTX401 for individuals with GSDIa. This study will help us understand how effective this treatment is over time.

Glycogen Storage Disease Type IA>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboInvestigational MedicinesPartially RemoteEndocrinologyInternal Medicine

Urinary Incontinence in Children: StayDry Study

We are exploring how stopping medication for urinary incontinence affects recurrence and overall well-being in children. The study compares abrupt versus gradual withdrawal of treatments like solifenacin and mirabegron.

Daytime Urinary Incontinence>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesUrology

Pneumococcal Vaccine Response: Age and HIV Impact

We are studying how age and HIV infection affect the immune response to pneumococcal vaccination. This research aims to improve vaccine effectiveness for different populations.

HIV Infection6-12 monthsConfirmation phase (III)Monitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementInfectious DiseasesInternal Medicine

Carvedilol vs. Flecainide for Ventricular Arrhythmias

We are comparing two medications to see which one better reduces abnormal heartbeats in people with idiopathic ventricular arrhythmias. The study also looks at how these treatments affect quality of life and any side effects.

Ventricular ExtrasystolesMonomorphic Ventricular TachycardiaIdiopathic Ventricular Arrhythmias6-12 monthsMonitoring phase (IV)No PlaceboStandard MedicinesCardiology

Tranexamic Acid for Postoperative Complications in Plastic Surgery

We are studying whether applying tranexamic acid to surgical wounds can reduce re-bleeding and other complications after plastic surgery. This trial includes both men and women over 18 years old.

Healthy Participants Undergoing SurgeryMonitoring phase (IV)No PlaceboStandard MedicinesHematologyOrthopedics and Traumatology

Postoperative Sleep Quality: DEXSLEEP Study

We are testing whether dexmedetomidine can improve sleep and reduce fatigue in elderly patients after major surgery. This may help enhance recovery and overall well-being following surgery.

Healthy Participants Aged 60 and Older1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOtolaryngologyPsychiatry

Uncontrolled Asthma: Dupilumab vs. High Dose ICS

We are studying whether adding dupilumab to medium dose asthma medication helps reduce severe asthma attacks better than increasing the dose of current treatments. This trial is for adolescents and adults with uncontrolled asthma.

Asthma1-2 yearsMonitoring phase (IV)Post-Trial Drug AccessInvestigational MedicinesPartially RemoteAllergologyPulmonology

Hallux Valgus Surgery: Ropivacaine Ankle Block Study

We are investigating how different strengths of ropivacaine affect pain relief and recovery in patients undergoing hallux valgus repair surgery. This study aims to find the best concentration for effective anesthesia and reduced opioid use.

Bunion (Hallux Valgus)Monitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteOrthopedics and TraumatologyOtolaryngology

Dementia: New Treatments for Agitation

We are exploring whether certain psychotropic medications can help reduce agitation in dementia patients who haven't responded to standard treatments. The study also examines potential side effects and personalized treatment methods.

Agitated BehaviorDementia≤3 monthsMonitoring phase (IV)Investigational MedicinesNeurologyPsychiatry

Denosumab: Impact on Muscle Strength and Insulin Sensitivity

We are studying whether denosumab can improve muscle strength and insulin sensitivity in participants. This trial compares its effects to a placebo to understand its potential benefits.

Diabetes MellitusPostmenopausal Osteoporosis6-12 monthsMonitoring phase (IV)Standard MedicinesEndocrinologyHepatologyInternal Medicine

HIV Prevention: Long-Acting Injectable Cabotegravir vs. Daily Oral Medication

We are studying whether a long-acting injectable form of cabotegravir is more effective than daily oral medication for preventing HIV in men who have sex with men. This trial aims to understand how well each option works over time and their impact on participants' health and behaviors.

HIV Prevention>2 yearsConfirmation phase (III)Monitoring phase (IV)11-15 visitsNo PlaceboInvestigational MedicinesInfectious DiseasesInternal Medicine

Andersen-Tawil Syndrome: Flecainide Therapy Study

We are exploring whether flecainide alone or in combination with other medications is more effective for managing heart rhythm issues in patients with Andersen-Tawil syndrome and multifocal ectopic contractions.

Andersen-Tawil SyndromeMultifocal Ectopic Purkinje-related Premature Contractions≤3 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteCardiology

External Cephalic Version: Propofol vs. Spinal Analgesia

We are comparing the use of Propofol and spinal analgesia for sedation during a procedure to turn breech babies. Our goal is to find out which method has a higher success rate and fewer complications.

External Cephalic Version>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGynecology and ObstetricsInternal Medicine

Membranous Nephropathy: Personalized Rituximab Treatment Study

We are exploring whether an AI-driven personalized treatment plan for membranous nephropathy is more effective than standard rituximab treatment. This study aims to improve patient outcomes and remission rates.

Acute GlomerulonephritisMembranous Nephropathy6-12 monthsConfirmation phase (III)Monitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesNephrology

Axial Spondyloarthritis and Psoriatic Arthritis: Ixekizumab Study

We are examining how ixekizumab affects inflammation in patients with axial spondyloarthritis and psoriatic arthritis. This study uses whole-body MRI to measure changes in joints and entheses.

Psoriatic ArthritisAxial Spondyloarthritis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOrthopedics and TraumatologyRheumatology