Search Clinical Trials in the European Union

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3581-3600 of 3,900 trials

Emergency Pain Relief: Sublingual Sufentanil Study

We are investigating whether sublingual sufentanil can effectively manage moderate to severe pain in emergency patients after a single trauma. The study will also assess safety and compare it to standard pain management methods.

Pain in Limb6-12 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesInternal MedicineOrthopedics and TraumatologyOtolaryngologyPsychiatry

Chronic Heart Failure: Omecamtiv Mecarbil Study

We are testing a new medication for people with chronic heart failure and severely reduced heart function. The study aims to see if it can improve heart health outcomes compared to a placebo.

Heart Failure with Reduced Ejection Fraction>2 yearsConfirmation phase (III)11-15 visitsInvestigational MedicinesCost ReimbursementPartially RemoteCardiologyInternal Medicine

Atrial Fibrillation: Flecainide vs. Amiodarone

We are studying whether flecainide is more effective and safe than amiodarone for treating paroxysmal atrial fibrillation in patients with coronary disease. This trial aims to see if it can restore normal heart rhythm faster and reduce hospital visits.

Coronary Artery DiseaseParoxysmal Atrial Fibrillation>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesCardiologyInternal Medicine

Ketamine for Depression: Brain Imaging Study

We are investigating how different forms of ketamine affect brain function in individuals with depression. This study aims to improve our understanding of how ketamine may help in treating this condition.

Healthy Participants>2 yearsSafety phase (I)Standard MedicinesPsychiatry

Refractory Schizophrenia: NaBen® with Clozapine

We are studying whether NaBen®, a new medication, can help adults with refractory schizophrenia who still have symptoms despite treatment with clozapine. The trial will also assess the safety of this combination therapy.

Treatment-resistant Schizophrenia≤3 monthsEfficacy phase (II)Confirmation phase (III)Investigational MedicinesCost ReimbursementPsychiatry

Glioblastoma Multiforme: Itraconazole with Radiotherapy and Temozolomide

We are studying whether adding Itraconazole to standard radiotherapy and temozolomide is safe for patients with newly diagnosed glioblastoma. Our goal is to find the best dose and understand its effects on survival and quality of life.

Glioblastoma≤3 monthsSafety phase (I)6-10 visitsNo PlaceboStandard MedicinesNeurologyOncology

Cervical Dystonia: IPN10200 Treatment Study

We are studying the effects of IPN10200 on reducing symptoms of cervical dystonia in adults. This trial will help us understand if it can improve pain and disability compared to a placebo.

Cervical Dystonia6-12 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesPartially RemoteNeurologyOrthopedics and Traumatology

Non-Small Cell Lung Cancer: Cemiplimab and TEDOPI® Study

We are testing a new combination therapy for patients with non-small cell lung cancer who have not progressed after initial treatment. The goal is to see if this therapy helps clear cancer markers and improves survival compared to standard treatment.

Non-Small Cell Lung Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteOncology

Crohn's Disease in Children: Budesonide Treatment

We are studying a topical treatment with budesonide for children with Crohn's disease affecting the esophagus, stomach, or duodenum. The goal is to see if it helps reduce inflammation in these areas.

Crohn's Disease≤3 monthsConfirmation phase (III)No PlaceboStandard MedicinesGastroenterologyPediatrics

Major Depressive Disorder: CYB003 Treatment Study

We are studying the effects of a new medication, CYB003, on symptoms of major depressive disorder in adults. This trial compares its effectiveness to a placebo to see if it may help improve mood and quality of life.

Major Depressive Disorder3-6 monthsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemotePsychiatry

Remdesivir for COVID-19 in Kidney Transplant Patients

We are studying whether a 10-day treatment with remdesivir can help kidney transplant recipients with mild or no COVID-19 symptoms avoid severe illness. The trial will also look at the safety and health outcomes of these patients.

COVID-196-12 monthsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesInfectious DiseasesNephrology

Type 2 Diabetes: RO7795081 Study

We are investigating the safety of RO7795081, a new compound for type 2 diabetes and weight control. The study also looks at how this compound affects the processing of other approved medications in the body.

Obesity and Overweight6-12 monthsSafety phase (I)DiabetologyEndocrinologyInternal Medicine

Systemic Lupus Erythematosus: CC-97540 CAR T Cell Therapy

We are studying a new CAR T cell therapy for people with active lupus who haven't responded to standard treatments. The goal is to see if it can improve symptoms and overall health.

Systemic Lupus ErythematosusLupus Nephritis>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteHematologyRheumatology

Chronic HDV Infection: Tobevibart and Elebsiran Study

We are studying a new combination therapy for people with chronic HDV infection who haven't responded to prior treatment. The goal is to see if this therapy can effectively reduce the virus and improve liver health.

Chronic Hepatitis D Virus Infection>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementHepatologyInfectious Diseases

Psoriatic Arthritis: Lutikizumab and Risankizumab Study

We are testing the effectiveness and safety of a combination of two medications for adults with active psoriatic arthritis. This study aims to see if the combination works better than each medication alone.

Psoriatic Arthritis3-6 monthsEfficacy phase (II)No PlaceboInvestigational MedicinesInternal MedicineRheumatology

B-cell Non-Hodgkin Lymphomas: CAR-T Cell Therapy

We are testing a new CAR-T cell treatment for patients with B-cell non-Hodgkin lymphomas. The goal is to see how safe and well-tolerated this therapy is.

Non-Hodgkin LymphomaSafety phase (I)HematologyOncology

UTI Vaccine Study for Adults Aged 18-64

We are testing a new vaccine to see if it can safely prevent urinary tract infections caused by E. coli in adults, especially women. The study will compare its effectiveness to a placebo.

Urinary Tract Infections1-2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteInfectious DiseasesUrology

Metastatic Colorectal Cancer: Cetuximab vs. Bevacizumab

We are studying whether continuing cetuximab treatment helps patients with specific types of metastatic colorectal cancer after their first treatment stops working. This trial compares it to another treatment option to see which is more effective.

Metastatic Colorectal CancerConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesOncology

BI 3810477: Tolerance Study in Healthy Adults

We are testing how well healthy adults tolerate multiple doses of a new medication called BI 3810477. This study aims to gather important safety information for future use.

Healthy VolunteersSafety phase (I)DermatologyInternal MedicineOphthalmologyOtolaryngologyPediatricsPsychiatry

Debio 1453P: First-in-Human Safety Study

We are testing a new oral medication in healthy adults to see how safe it is and how the body processes it. This study aims to gather important information for future treatments.

Gonorrhoea6-12 monthsSafety phase (I)Infectious DiseasesInternal Medicine