Search Clinical Trials in the European Union

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3601-3620 of 3,900 trials

Endometrial Cancer: Sacituzumab Tirumotecan and Pembrolizumab Study

We are studying a combination of sacituzumab tirumotecan and pembrolizumab for people with advanced or recurrent endometrial cancer. The goal is to see if this combination works better than pembrolizumab alone.

Endometrial CarcinomaConfirmation phase (III)Investigational MedicinesCost ReimbursementPartially RemoteInternal MedicineOncology

Cognitive Improvement in Down Syndrome: Bumetanide Study

We are investigating whether Bumetanide can enhance cognitive functions in children and adolescents with Down syndrome aged 10-16. This study aims to explore its effects on both thinking skills and related psychological aspects.

Down Syndrome>2 yearsEfficacy phase (II)6-10 visitsStandard MedicinesPediatricsPsychiatry

Low-Grade Upper Tract Urothelial Cancer: UGN-104 Treatment Study

We are studying a new treatment called UGN-104 for patients with low-grade upper tract urothelial cancer. The trial aims to see how well it reduces tumors and its safety compared to existing options.

Low-grade Upper Tract Urothelial Cancer1-2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementOncologyUrology

IgA Nephropathy: Felzartamab Infusions

We are studying the effects of felzartamab infusions on adults with IgA nephropathy to see if it helps reduce protein in urine and improve kidney function compared to a placebo.

IgA Nephropathy>2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementInternal MedicineNephrology

Oligometastatic Prostate Cancer: Lu-PSMA and Radiotherapy Study

We are investigating whether combining Lu-PSMA with stereotactic radiotherapy improves survival and quality of life for patients with oligometastatic prostate cancer compared to radiotherapy alone.

Metastatic Prostate Cancer3-6 monthsEfficacy phase (II)No PlaceboStandard MedicinesOncologyUrology

Sentinel Node Biopsy: ICG-99mTc-Nanoscan Tracer

We are studying a new hybrid tracer to improve the detection of sentinel nodes in cancer patients. This trial aims to see how well it works compared to traditional methods during preoperative imaging.

Melanoma and Other Head/Neck CancersEfficacy phase (II)No PlaceboStandard MedicinesOncologyOtolaryngology

PCOS Fertility: Letrozole vs. Gonadotropins

We are studying whether continuing ovulation induction with letrozole is more effective than switching to gonadotropins for women with polycystic ovary syndrome. The trial also looks at safety, quality of life, and costs related to fertility treatment.

Polycystic Ovary Syndrome (PCOS)1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteEndocrinologyGynecology and ObstetricsInternal Medicine

Personalized Treatment for High-Risk Breast Cancer: PETREMAC Trial

We are studying how personalized therapies can improve outcomes for patients with high-risk breast cancer. The trial looks at treatment responses and aims to enhance surgical options while ensuring safety.

Breast Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Alopecia Areata: Ritlecitinib Study

We are investigating whether two doses of ritlecitinib can help people aged 12 and older with alopecia areata regrow their scalp hair. The study compares the effects of the medication to a placebo.

Alopecia Areata6-12 monthsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteAllergologyDermatology

Type 2 Diabetes: NNC9733-0001 Study

We are researching a new medicine, NNC9733-0001, in healthy individuals and those with type 2 diabetes. The goal is to learn more about its effects and potential benefits.

Healthy ParticipantsType 2 Diabetes>2 yearsSafety phase (I)DiabetologyEndocrinology

Glioblastoma: Adding Zoledronic Acid to Treatment

We are studying whether adding zoledronic acid to standard chemotherapy can help improve survival and treatment response in patients with glioblastoma. We also want to assess its safety and tolerability.

Glioblastoma3-6 monthsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteNeurologyOncology

Dry Eye Disease: PRGF Eye Drops for Glaucoma Patients

We are studying whether PRGF eye drops can help relieve dry eye symptoms in patients with glaucoma. The trial also looks at the safety of these eye drops for this condition.

GlaucomaDry Eye Disease≤3 monthsConfirmation phase (III)Monitoring phase (IV)Investigational MedicinesOphthalmology

Severe Asthma: Verekitug (UPB-101) Study

We are studying the long-term safety and effects of verekitug in adults with severe asthma. This research aims to see how it helps manage asthma attacks and improve breathing.

Severe Asthma1-2 yearsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteAllergologyPulmonology

Bowel Dysfunction After Rectal Cancer Surgery: Irrigation vs. Suppositories

We are comparing transanal irrigation and glycerol suppositories to see which treatment better improves bowel function and quality of life for patients after rectal cancer surgery.

Low Anterior Resection Syndrome≤3 monthsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteGastroenterologyInternal Medicine

Microscopic Colitis: SAR444336 Treatment Study

We are investigating a new treatment, SAR444336, for adults with microscopic colitis in remission. The study aims to see if it can effectively manage symptoms without steroids and evaluate its safety.

Microscopic Colitis6-12 monthsEfficacy phase (II)11-15 visitsInvestigational MedicinesPartially RemoteGastroenterologyInternal Medicine

Choline Chloride for Injection in Intestinal Failure

We are studying the safety and effectiveness of Choline Chloride for Injection in adolescents and adults with intestinal failure. This trial compares the treatment to a placebo to see how well it supports patients receiving long-term parenteral nutrition.

Intestinal Failure1-2 yearsEfficacy phase (II)Confirmation phase (III)16-20 visitsPost-Trial Drug AccessStandard MedicinesGastroenterologyNephrology

Alzheimer's Disease: NPI-001 Study

We are testing a new oral medication, NPI-001, for people aged 50 to 85 with Mild Cognitive Impairment or mild dementia due to Alzheimer's. The study aims to assess its safety and effects on brain health and cognitive function.

Alzheimer's Disease1-2 yearsEfficacy phase (II)11-15 visitsStandard MedicinesPartially RemoteInternal MedicineNeurology

Blood Cancer Treatment: CCS1477 Study

We are testing the safety and effects of the experimental drug CCS1477 in patients with advanced blood and bone marrow cancers. This study aims to see how well it works alone and in combination with other treatments.

Acute Myeloid Leukaemia (AML)Myelodysplastic Syndrome (MDS)Multiple Myeloma (MM)Safety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesHematologyOncology

Hepatocellular Carcinoma: ALN-BCAT Treatment

We are evaluating a new treatment called ALN-BCAT for patients with liver cancer. The goal is to see how well it works compared to current options.

Advanced or Metastatic Liver Cancer>2 yearsSafety phase (I)HepatologyOncology

Lung Transplantation: Heparin-Free Heart-Lung Support

We are studying a new method of heart-lung support without blood thinners during lung transplantation. This trial aims to see if it is safe and effective for improving patient outcomes.

Lung Transplantation1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicinePulmonology