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3621-3640 of 3,900 trials

Prostate Cancer: Androgen Deprivation Therapy and PSMA

We are studying how androgen deprivation therapy affects the expression of a specific protein in metastatic prostate cancer. This research may help us understand treatment responses and disease progression better.

Metastatic Prostate Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyUrology

Autoimmune Disease: CAR-Expressing NK Cell Therapy

We are testing a new therapy using engineered immune cells for people with active B-cell driven autoimmune diseases. The study aims to assess safety and effectiveness in conditions like lupus and scleroderma.

Systemic Lupus ErythematosusSystemic SclerosisIdiopathic Inflammatory MyopathySafety phase (I)Efficacy phase (II)16-20 visitsNo PlaceboInvestigational MedicinesInfectious DiseasesRheumatology

Type 1 Diabetes: NNC0194-0499 and Semaglutide Study

We are exploring how a new treatment and its combination with semaglutide can help control blood sugar in people with type 1 diabetes. This study aims to improve management options for those living with this condition.

Type 1 Diabetes3-6 monthsSafety phase (I)DiabetologyEndocrinology

Vaginal Estrogen Treatment: Effects on Blood Clotting

We are studying how local vaginal estrogen affects blood clotting in postmenopausal women. This includes examining its impact on women with a history of blood clots.

Vulvovaginal Atrophy>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGynecology and ObstetricsInternal Medicine

Meningococcal Vaccine Study for Ages 10-20

We are testing a booster dose of the rMenB+OMV NZ vaccine in healthy participants aged 10 to 20 who were vaccinated in early childhood. The study aims to see how well it enhances their immune response and evaluates its safety.

Invasive Meningococcal DiseaseConfirmation phase (III)≤5 visitsNo PlaceboInvestigational MedicinesInfectious DiseasesPediatrics

Multiple Sclerosis: OBE-CEL Treatment Study

We are testing a new treatment for people with refractory progressive forms of multiple sclerosis. The study aims to assess its safety and how well it may work.

Progressive Multiple Sclerosis>2 yearsSafety phase (I)Neurology

Type 1 Diabetes: Deferoxamine for Hypoxia Response

We are studying whether deferoxamine can improve how people with type 1 diabetes react to low oxygen levels. This trial will help us understand its potential benefits in managing diabetes.

Type 1 Diabetes>2 yearsEfficacy phase (II)6-10 visitsStandard MedicinesEndocrinologyInternal Medicine

Solid Tumors: MK-5684 Study

We are testing a new treatment, MK-5684, for people with certain solid tumors to see if it helps them live longer without disease progression. The study also evaluates its safety and effectiveness compared to standard care.

Breast CancerOvarian CancerEndometrial Cancer6-12 monthsEfficacy phase (II)Confirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesOncology

LSD Levels in the Brain: Neuroimaging Study

We are investigating how LSD is processed in the human brain using advanced imaging techniques. This research may help us understand its effects on mental health.

Healthy Participants1-2 yearsSafety phase (I)NeurologyPsychiatry

Chronic Heart Failure: Combined Diuretic Therapy Study

We are comparing a new combined diuretic treatment to standard therapies for people with chronic heart failure. The goal is to see if it improves exercise capacity and fluid management.

Congestive Heart Failure>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesCardiologyInternal Medicine

Rezafungin for Chronic Pulmonary Aspergillosis Treatment

We are studying whether rezafungin can effectively treat chronic pulmonary aspergillosis in adults with few treatment options. The trial will assess both the effectiveness and safety of this medication.

Chronic Pulmonary Aspergillosis6-12 monthsEfficacy phase (II)>20 visitsNo PlaceboStandard MedicinesCost ReimbursementInfectious DiseasesPulmonology

Melanoma Treatment: Comparing Immune Therapies

We are studying two different immune therapy treatments for patients with resectable stage III melanoma. Our goal is to see which treatment may help improve survival without disease progression.

Stage III Malignant MelanomaConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesDermatologyOncology

Insomnia in Adolescents: Melatonin vs. Quetiapine

We are studying whether melatonin or low-dose quetiapine can improve sleep in adolescents with psychiatric disorders and insomnia. We’ll also look at how these treatments affect overall well-being and daily functioning.

Psychiatric Disorders and Insomnia≤3 monthsEfficacy phase (II)Confirmation phase (III)6-10 visitsStandard MedicinesCost ReimbursementPartially RemotePsychiatry

Metastatic Colorectal Cancer: New Diagnostic Test for Treatment Guidance

We are studying a new test to help doctors determine the best third-line therapy for patients with metastatic colorectal cancer. The goal is to see if this test provides accurate and reliable information for treatment decisions.

Metastatic Colorectal Cancer>2 yearsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesInternal MedicineOncology

Metastatic Melanoma: V940 and Pembrolizumab Study

We are studying a new treatment combining V940 with pembrolizumab for people with metastatic melanoma. The aim is to see if this combination helps improve survival compared to a placebo.

Melanoma>2 yearsEfficacy phase (II)Investigational MedicinesCost ReimbursementOncology

Venous Leg Ulcers: EscharEx Treatment Study

We are studying whether EscharEx can help improve wound healing in people with Venous Leg Ulcers compared to a placebo. This trial aims to assess its safety and effectiveness in wound care.

Venous Leg Ulcer6-12 monthsConfirmation phase (III)>20 visitsInvestigational MedicinesDermatologyInternal Medicine

Postoperative Pain Management: Fentanyl Nasal Spray

We are studying a fentanyl nasal spray for pain relief after orthopedic surgery, comparing it to a placebo and standard morphine treatment. The goal is to assess its effectiveness and side effects in managing pain.

Postoperative Pain Relief≤3 monthsConfirmation phase (III)Investigational MedicinesInternal MedicineOrthopedics and TraumatologyPsychiatry

Chronic Rhinosinusitis: Stopping Treatment Study

We are investigating if patients with severe nasal polyps can safely stop treatment after a year without symptoms. We also want to see if one medication works better than the other for achieving this.

Chronic Rhinosinusitis with Nasal Polyps1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesAllergologyOtolaryngology

Advanced Cancer: TH9619 Treatment Study

We are evaluating the safety and potential anticancer effects of a new drug, TH9619, in patients with advanced cancer. This study aims to understand how different doses may work in treating this condition.

Solid TumorsSafety phase (I)Oncology

Head and Neck Cancer: Ficerafusp Alfa with Pembrolizumab

We are studying whether ficerafusp alfa combined with pembrolizumab can effectively treat patients with recurrent or metastatic head and neck cancer. This trial aims to find the best dose and compare its effects to a placebo.

Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma1-2 yearsEfficacy phase (II)Confirmation phase (III)Investigational MedicinesCost ReimbursementOncology