Search Clinical Trials in the European Union

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3641-3660 of 3,900 trials

Reducing Complications After Pancreatoduodenectomy: HOP Bundle Study

We are investigating whether a combination of hydrocortisone, octreotide, and a teres ligament patch can help prevent major complications in patients undergoing high-risk pancreatoduodenectomy. This study also looks at its effect on specific complications like pancreatic fistulas.

Resectable Pancreatic Cancer3-6 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOncologyOrthopedics and Traumatology

Oxytocin Infusion: Effects on Sensory Nerves

We are studying how intravenous oxytocin affects sensory nerve responses and cognitive performance in healthy volunteers. This research may help us understand its role in pain perception and inflammation.

Healthy Participants>2 yearsSafety phase (I)≤5 visitsStandard MedicinesNeurologyPsychiatry

Chronic Limb-Threatening Ischemia: Bone Marrow Cell Therapy

We are comparing a new treatment using your own bone marrow cells with standard care for diabetic patients with severe circulation problems. The goal is to see if this therapy improves tissue oxygen levels and overall health.

Diabetic Foot SyndromeLower Limb Ischemia6-12 monthsEfficacy phase (II)Confirmation phase (III)No PlaceboInvestigational MedicinesCardiologyEndocrinologyInternal MedicineOrthopedics and Traumatology

Knee Surgery: Testing SRSD107 for Blood Clot Prevention

We are studying whether SRSD107 can effectively prevent blood clots in adults undergoing knee replacement surgery. We will also assess how safe it is compared to the standard treatment, enoxaparin.

Venous Thromboembolism6-12 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesCost ReimbursementPartially RemoteCardiologyOrthopedics and Traumatology

WSD0922-FU for Advanced Non-Small Cell Lung Cancer

We are studying a new treatment for patients with advanced NSCLC who have a specific mutation and did not respond to prior therapy. The goal is to see if this treatment can help shrink tumors and improve survival.

Non-Small Cell Lung Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncologyPulmonology

GSK4418959 for Solid Tumors: A New Treatment Approach

We are investigating the safety and early effectiveness of the DNA-repair inhibitor GSK4418959 in adults with specific solid tumors. This study looks at the drug alone and with other cancer treatments to see how well it works.

Colorectal Cancer3-6 monthsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteOncology

Liver Surgery: Blood Clot Prevention Study

We are comparing two methods of preventing blood clots in patients undergoing liver resection. The goal is to find out which method is safer and more effective in reducing clot risks.

Liver SurgeryMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyHematologyOrthopedics and Traumatology

Hidradenitis Suppurativa: Tibulizumab Study

We are evaluating the effects of tibulizumab on skin lesions and quality of life for adults with hidradenitis suppurativa. The study also looks at the safety and tolerability of this treatment.

Hidradenitis Suppurativa6-12 monthsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesDermatology

High-Dose Influenza Vaccine for Adults 60 and Older

We are studying a new high-dose flu vaccine to see if it provides better immune protection than a standard vaccine for adults aged 60 and above. The trial will also assess the safety of this new vaccine.

Influenza Immunization1-2 yearsConfirmation phase (III)≤5 visitsNo PlaceboInvestigational MedicinesCost ReimbursementGastroenterologyInfectious Diseases

Sickle Cell Disease: Tebapivat Study

We are investigating a new medication, tebapivat, to see if it helps improve anemia in people with sickle cell disease. The study will also look at its safety and effects on fatigue and pain.

Sickle Cell Disease3-6 monthsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteHematologyInternal Medicine

Vitamin D3 Supplementation: Young Adults vs. Seniors

We are comparing how vitamin D3 affects young adults and seniors to find the best supplementation approach for each group. The study also examines how respiratory illnesses might influence vitamin D levels.

Healthy Participants1-2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesAllergologyDermatologyEndocrinologyInfectious DiseasesInternal MedicineNephrologyOphthalmologyOtolaryngologyPediatricsPsychiatryPulmonology

Chronic Rhinosinusitis with Nasal Polyps: Tapering Biologics

We are studying whether patients with stable chronic rhinosinusitis can safely reduce their biologic medication dosage after a year. This trial compares the effects of Mepolizumab and Dupilumab on disease control.

Chronic Rhinosinusitis with Nasal Polyps1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesAllergologyOtolaryngology

Metastatic Uveal Melanoma: Liver Radiotherapy with Tebentafusp

We are studying if adding liver-directed radiotherapy to the standard treatment helps patients with metastatic uveal melanoma live longer and stay on treatment longer. This trial also looks at how the body responds to the combination therapy.

Metastatic Uveal MelanomaEfficacy phase (II)No PlaceboStandard MedicinesHepatologyOncology

Gastric Cancer: Zolbetuximab with Pembrolizumab and Chemotherapy

We are studying a new treatment combination for adults with advanced gastric cancer to see if it works better than standard therapies. This trial is for patients with specific tumor markers.

Gastric CancerMetastatic Gastric CancerGastroesophageal Junction AdenocarcinomaConfirmation phase (III)Investigational MedicinesCost ReimbursementPartially RemoteGastroenterologyOncology

Study on Banned Substances: ESPAMA_3

We are investigating how exposure to substances prohibited by the World Anti-Doping Agency affects healthy volunteers. This study aims to gather initial insights into their impact.

Healthy VolunteersSafety phase (I)

Anal High-Grade Lesions: Sinecatechins Ointment

We are studying whether adding a topical ointment to standard treatment helps patients with high-grade anal lesions achieve better results. The goal is to see if it reduces lesions and prevents recurrence.

Anal High-Grade Squamous Intraepithelial Lesions (HSIL)1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteGastroenterologyOncology

Rezafungin for Fungal Infections in Critically Ill Patients

We are studying how Rezafungin levels change in patients on ECMO, a life-support treatment. This research aims to understand its effectiveness and any potential side effects.

Invasive Candidiasis>2 yearsConfirmation phase (III)Monitoring phase (IV)16-20 visitsNo PlaceboStandard MedicinesInfectious DiseasesInternal MedicinePulmonology

Atopic Dermatitis: Long-term Study of APG777

We are examining the long-term safety and effectiveness of APG777 in patients with moderate-to-severe atopic dermatitis who have already used this treatment. The goal is to see how well it works over time and if it remains safe.

Atopic DermatitisEfficacy phase (II)Post-Trial Drug AccessInvestigational MedicinesPartially RemoteAllergologyDermatology

GHF-201: New Drug Safety Study

We are testing a new medication called GHF-201 in healthy adults to see how safe it is and how the body handles it. This study aims to gather important information before it can be used in patients.

Adult Polyglucosan Body DiseaseSafety phase (I)Internal Medicine

Non-Small Cell Lung Cancer: BMS-986504 Treatment Study

We are evaluating a new medication for patients with advanced non-small cell lung cancer who have a specific genetic deletion. The study aims to understand how well it works and its safety compared to previous treatments.

Advanced or Metastatic Non-small Cell Lung CancerEfficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesOncologyPulmonology