Search Clinical Trials in the European Union

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461-480 of 552 trials

Cardiac Surgery: Angiotensin II vs. Noradrenaline

We are studying whether angiotensin II can better prevent kidney injury compared to noradrenaline in patients undergoing cardiac surgery. This research may help improve kidney health outcomes after surgery.

Acute Kidney Injury>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboInvestigational MedicinesPartially RemoteCardiologyInternal MedicineNephrology

Metastatic Renal Cell Carcinoma: Immunotherapy and Tumor Treatment Study

We are studying how surgery and radiation affect survival and tumor growth in patients with metastatic renal cell carcinoma receiving immunotherapy. This trial aims to improve treatment strategies and quality of life for these patients.

Advanced Kidney Cancer1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOncology

Hemophilia A: Efanesoctocog Alfa Treatment Study

We are studying the long-term effects of efanesoctocog alfa on joint health in people with hemophilia A. The trial aims to see how well it prevents joint bleeds and improves quality of life.

Haemophilia A1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementHematologyOrthopedics and Traumatology

Neurogenic Orthostatic Hypotension: Fludrocortisone Treatment

We are studying whether fludrocortisone can improve blood pressure and reduce symptoms in patients with neurogenic orthostatic hypotension. The trial will also assess the safety and quality of life for participants.

Neurogenic Orthostatic Hypotension≤3 monthsMonitoring phase (IV)Investigational MedicinesInternal MedicineNeurology

Kidney Health After Transplant: Dapagliflozin Study

We are studying how dapagliflozin affects kidney structure and inflammation in patients with impaired kidney function one year after transplantation. This research may help us understand better treatments for kidney transplant recipients.

Chronic Kidney Disease (CKD)3-6 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesEndocrinologyNephrology

Infant Immunity to Whooping Cough: Maternal Vaccination Study

We are studying how vaccines given to pregnant women affect their infants' immunity to whooping cough. Our goal is to find out what factors influence the transfer of protective antibodies from mothers to their babies.

Whooping Cough>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementGynecology and ObstetricsInfectious DiseasesInternal Medicine

Long COVID: Fibroblast Activity Study with [68Ga]FAPI PET/CT

We are investigating if patients with ongoing long COVID symptoms have higher fibroblast activity than those who have recovered. This may help us understand the underlying causes of long-term health issues after COVID-19.

Long COVIDConfirmation phase (III)Monitoring phase (IV)No PlaceboInvestigational MedicinesCost ReimbursementInternal MedicinePulmonology

Turner Syndrome: Estrogen Therapy Comparison

We are studying the long-term effects of oral versus transdermal estrogen replacement therapy in women with Turner syndrome. This research aims to clarify health risks and benefits associated with each treatment method.

Turner's Syndrome6-12 monthsMonitoring phase (IV)No PlaceboStandard MedicinesEndocrinologyInternal Medicine

Opioid-Induced Respiratory Depression: Naloxone and Nalmefene Study

We are studying how well naloxone and nalmefene can reverse breathing problems caused by opioids in both new and long-term users. This research aims to improve treatment options for respiratory depression in real-life settings.

Healthy VolunteersOpioid Use Disorder>2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesCost ReimbursementCardiologyInternal MedicineOtolaryngologyPulmonology

Schizophrenia: Cariprazine for Cognitive Function

We are studying how cariprazine affects cognitive functioning in patients with schizophrenia who need changes to their current treatment. The trial will also look at overall quality of life and any side effects.

Acute Schizophrenia6-12 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesPsychiatry

Cardiac Arrest and Ventricular Fibrillation: RIME-IVF Study

We are investigating how beta-blocker treatment affects patients with idiopathic ventricular fibrillation and those who have had out-of-hospital cardiac arrests. We also aim to understand the quality of life for survivors of cardiac arrest.

Idiopathic Ventricular FibrillationMonitoring phase (IV)No PlaceboStandard MedicinesCardiology

Heart Attack Treatment: Evolocumab vs. Standard Care

We are studying whether the medication evolocumab can better prevent heart-related problems compared to standard treatments for patients who have recently had a heart attack. This trial focuses on improving cholesterol control and reducing hospitalizations.

Heart Attack>2 yearsMonitoring phase (IV)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteCardiologyInternal Medicine

Dopamine Changes in Depression: Escitalopram vs. Bupropion

We are studying how rewards affect dopamine levels in the brain of people with major depressive disorder compared to healthy volunteers. This trial also looks at how two different antidepressants may influence these changes.

Major Depression>2 yearsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesPsychiatry

Polymyalgia Rheumatica: Hydrocortisone Supplement Study

We are investigating whether supplemental hydrocortisone helps improve quality of life for patients with polymyalgia rheumatica or giant cell arteritis experiencing adrenal insufficiency. The focus is on how it affects fatigue during stress.

Glucocorticoid Induced Adrenal Insufficiency6-12 monthsMonitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteEndocrinologyRheumatology

Siponimod for Progressive Multiple Sclerosis

We are studying how siponimod affects brain lesions and nerve damage in patients with secondary progressive MS. The trial also looks at its impact on cognitive health and long-term safety.

Progressive Multiple Sclerosis>2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesNeurology

Neuroinflammation in Major Depressive Disorder: InflaDep Study

We are investigating the patterns of neuroinflammation in people with major depressive disorder compared to those in remission and healthy individuals. This study may help us understand the links between inflammation and depression symptoms.

Depressive Disorder>2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesPsychiatry

Ulcerative Colitis: Tofacitinib's Impact on Blood Clotting

We are studying how tofacitinib affects blood clotting and platelet function in patients with ulcerative colitis. This trial also compares its effects to other treatments and collects samples for future research.

Ulcerative Colitis3-6 monthsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesGastroenterologyHematology

Neovascular Age-Related Macular Degeneration: AI-Assisted Treatment

We are exploring how artificial intelligence can help improve treatment for patients with active neovascular AMD. This study aims to make the treatment process easier for patients and healthcare providers.

Neovascular Age-Related Macular Degeneration1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOphthalmology

Glaucoma: Oral Semaglutide Study

We are investigating whether oral semaglutide can safely improve retinal function in patients with open-angle glaucoma. This research may help find new ways to protect vision in those affected by this condition.

Glaucoma>2 yearsMonitoring phase (IV)≤5 visitsStandard MedicinesCost ReimbursementEndocrinologyOphthalmology

Colonoscopy Prep: Comparing Plenvu® and Picoprep®

We are studying how well Plenvu® works compared to Picoprep® for cleaning the bowel before a colonoscopy. The goal is to see which option is more effective and easier for patients to tolerate.

Healthy Participants for Colonoscopy Preparation>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterology