Search Clinical Trials in the European Union

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521-540 of 3,900 trials

Relatlimab and Nivolumab for Young Lymphoma Patients

We are studying a combination of two medications for children and young adults with recurrent or hard-to-treat Hodgkin and Non-Hodgkin lymphoma. The goal is to understand their safety and how well they may work.

Classical Hodgkin Lymphoma and Non-Hodgkin Lymphoma3-6 monthsSafety phase (I)Efficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteOncologyPediatrics

Elderly Surgery: Comparing Anesthesia Methods

We are studying how desflurane, sevoflurane, and propofol affect the risk of delirium and cognitive function in elderly patients after major abdominal surgery. This research aims to improve recovery outcomes for older adults undergoing surgery.

Postoperative Delirium>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesPartially Remote

Tranexamic Acid for Preventing Bleeding in Tooth Extractions

We are studying whether Tranexamic Acid Oral Solution can help reduce bleeding in patients taking blood thinners during tooth extractions. This trial aims to compare its effects with a placebo.

Bleeding from TeethConfirmation phase (III)Investigational MedicinesPartially RemoteGynecology and ObstetricsHematologyOtolaryngology

Fludarabine in Stem Cell Transplantation

We are studying how Fludarabine exposure varies among patients receiving reduced intensity stem cell transplants. The goal is to understand its effects on long-term health and potential side effects.

Patients Undergoing Stem Cell Transplant for Blood Cancer>2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesHematologyOncology

Heart Failure and Obesity: Weight Loss with Semaglutide

We are investigating whether weight loss using semaglutide is more effective than a calorie-restricted diet in improving physical performance for patients with heart failure and obesity. The study also looks at quality of life and heart health impacts from both weight loss methods.

Heart Failure with Reduced Ejection FractionObesity1-2 yearsEfficacy phase (II)11-15 visitsNo PlaceboInvestigational MedicinesPartially RemoteCardiologyDiabetologyEndocrinology

Splenic Marginal Zone Lymphoma: Rituximab with Zanubrutinib

We are comparing the effects of adding zanubrutinib to rituximab versus using rituximab alone in patients with untreated splenic marginal zone lymphoma. The goal is to see if the combination improves survival and response rates.

Splenic Marginal Zone Lymphoma>2 yearsConfirmation phase (III)11-15 visitsNo PlaceboStandard MedicinesOncology

Solid Tumors: Investigational Drug THE-0504

We are assessing the safety and tolerability of THE-0504 for patients with solid tumors. This trial aims to understand how well the drug is tolerated by participants.

Solid Tumors>2 yearsSafety phase (I)Oncology

Post-Menopausal Osteoporosis: BP16 vs. EU-Prolia

We are comparing a new treatment, BP16, to EU-Prolia for women with post-menopausal osteoporosis. The study looks at how well each treatment improves bone health and their safety.

Post-Menopausal Osteoporosis1-2 yearsConfirmation phase (III)11-15 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteEndocrinologyRheumatology

Advanced Non-Small Cell Lung Cancer: BAY2927088 Study

We are testing a new treatment for patients with advanced NSCLC who have mutations in the EGFR and/or HER2 genes. This study aims to explore its effects on cancer progression.

Advanced Non-Small Cell Lung Cancer>2 yearsSafety phase (I)Efficacy phase (II)OncologyPulmonology

Esophageal Cancer Detection: Fluorescent Tracers Study

We are testing a new method using oral fluorescent tracers to help detect early esophageal adenocarcinomas in patients with Barrett's esophagus. This study aims to see if this approach improves detection compared to standard endoscopy.

Barrett's EsophagusEfficacy phase (II)No PlaceboStandard MedicinesGastroenterologyOncology

Gastroparesis: Tradipitant Safety Study

We are evaluating the safety of a new medication, tradipitant, for patients with gastroparesis. The study also looks at how well it may help reduce symptoms and improve quality of life.

Gastroparesis3-6 monthsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteEndocrinologyGastroenterology

Severe Autoimmune Diseases: CD19-targeted CAR T Cell Therapy

We are testing a new CAR T cell treatment for individuals with severe autoimmune diseases that haven't responded to other therapies. The goal is to see if this approach is safe and how well it works.

Idiopathic Inflammatory MyopathyRheumatoid ArthritisSystemic Sclerosis>2 yearsSafety phase (I)Infectious DiseasesRheumatology

Major Depressive Disorder: Lumateperone Study

We are testing lumateperone as an additional treatment for people with major depressive disorder who aren't responding well to their current antidepressants. The study will help us understand its effectiveness and safety.

Major Depressive Disorder≤3 monthsConfirmation phase (III)6-10 visitsInvestigational MedicinesCost ReimbursementPartially RemotePsychiatry

Mucopolysaccharidosis Type II: DNL310 Treatment Study

We are investigating the long-term safety and effects of DNL310 in patients with MPS II. This study looks at how well the treatment works for cognitive and physical development.

Hunter's Syndrome>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteHematologyNeurology

Mild Male Factor Infertility: PKB171 Gel Study

We are testing a new intravaginal gel to see if it helps couples with mild male factor infertility achieve pregnancy. The study compares the gel's effects to a placebo over three treatment cycles.

Male Infertility6-12 monthsEfficacy phase (II)Confirmation phase (III)6-10 visitsInvestigational MedicinesPartially RemoteGynecology and ObstetricsUrology

Bimekizumab for Children with Moderate to Severe Plaque Psoriasis

We are studying how well bimekizumab works compared to ustekinumab in children and teens aged 6 to under 18 with moderate to severe plaque psoriasis. The trial will also look at safety and quality of life improvements.

Plaque PsoriasisConfirmation phase (III)Post-Trial Drug AccessStandard MedicinesAllergologyDermatology

Lung Cancer: Zipalertinib Study

We are testing Zipalertinib in patients with advanced non-small cell lung cancer who have specific genetic mutations. The goal is to see if it is safe and effective in treating their condition.

Non-Small Cell Lung CancerEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementOncologyPulmonology

Endometrial Cancer: Olaparib Maintenance Therapy

We are studying whether olaparib can help prevent cancer recurrence in patients with p53abn endometrial cancer after they receive chemoradiation. This trial compares olaparib treatment to observation alone.

p53abn HREC Patients Post-Surgery>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesPartially RemoteGynecology and ObstetricsOncology

Cardiovascular Collapse: Vasopressor Use During Intubation

We are studying whether giving vasopressors before intubation helps prevent cardiovascular collapse in critically ill adults. This research aims to improve safety during a critical medical procedure.

Critical Illness>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesCardiologyInternal Medicine

Sildenafil for Adults with Univentricular Heart Post-Fontan

We are studying whether adding sildenafil to existing treatments can improve physical performance and quality of life in adults with a univentricular heart after Fontan surgery.

Fontan Procedure and Univentricular Heart3-6 monthsConfirmation phase (III)Standard MedicinesCardiologyHematologyInternal MedicinePediatrics