Search Clinical Trials in the European Union

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541-560 of 3,900 trials

Locally Advanced NSCLC: Alectinib vs. Durvalumab

We are studying whether alectinib or entrectinib is more effective than durvalumab for patients with advanced non-small cell lung cancer who have not progressed after initial treatment. The trial also looks at quality of life and safety for participants.

Non-Small Cell Lung Cancer>2 yearsConfirmation phase (III)>20 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteOncology

Geographic Atrophy: Tinlarebant Treatment Study

We are exploring whether Tinlarebant can slow the growth of lesions in people with geographic atrophy and improve their vision. This study compares the new treatment to a placebo to assess its effectiveness.

Geographic Atrophy>2 yearsConfirmation phase (III)6-10 visitsInvestigational MedicinesOphthalmology

Ectopic Pregnancy: Mifepristone and Letrozole vs. Methotrexate

We are studying whether a new combination treatment is as effective as the standard medication for ectopic pregnancy. This trial will also look at side effects and the need for further medical interventions.

Ectopic Pregnancy>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesGynecology and Obstetrics

Progressive Glioblastoma: Perampanel Treatment Study

We are studying whether the medication Perampanel can help reduce tumor growth in patients with progressive glioblastoma before surgery. This trial also looks at quality of life and cognitive function to see how the treatment affects patients.

Progressive Glioblastoma>2 yearsEfficacy phase (II)Standard MedicinesPartially RemoteNeurologyOncology

Pneumonia: TAD® Treatment Study

We are testing whether TAD®, an intravenous treatment, can help prevent heart injury in hospitalized patients with pneumonia. This study aims to evaluate its safety and effectiveness as an additional therapy.

Heart Injury from Pneumonia1-2 yearsConfirmation phase (III)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteCardiologyInternal MedicinePulmonology

Graft-versus-Host Disease: MC0518 Treatment for Kids

We are studying a new treatment called MC0518 for children with steroid-refractory acute graft-versus-host disease after stem cell transplant. The goal is to see if it works better than the best available therapy.

Steroid Refractory Acute Graft Versus Host Disease>2 yearsEfficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesHematologyInfectious Diseases

DS-1103a: New Combination Therapy Study

We are testing a new combination therapy for patients with specific health conditions. This study aims to understand its safety and effectiveness in humans for the first time.

HER2 Positive Breast Cancer>2 yearsSafety phase (I)Oncology

Nitroglycerin for Esophageal Food Impaction

We are studying whether nitroglycerin can help relieve food impaction in the esophagus. This trial aims to see if it is an effective treatment for those who have trouble swallowing.

Esophageal Food Impaction>2 yearsEfficacy phase (II)Standard MedicinesGastroenterologyOtolaryngology

Prostate Cancer: RO7656594 Treatment Study

We are evaluating a new medication for patients with advanced or metastatic prostate cancer. The study focuses on its safety and how the body handles the drug.

Advanced or Metastatic Prostate Cancer>2 yearsSafety phase (I)Oncology

Growth Hormone Deficiency: LUM-201 Treatment Study

We are monitoring the long-term safety of LUM-201 in children with idiopathic growth hormone deficiency. This study also looks at how the treatment affects growth and related health markers.

Idiopathic Growth Hormone Deficiency>2 yearsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesEndocrinologyPediatrics

Anifrolumab for Polymyositis and Dermatomyositis

We are studying whether Anifrolumab can improve muscle strength and reduce corticosteroid use in adults with polymyositis and dermatomyositis compared to a placebo.

Polymyositis and Dermatomyositis>2 yearsConfirmation phase (III)≤5 visitsInvestigational MedicinesCost ReimbursementPartially RemoteInfectious DiseasesRheumatology

Breast Cancer Surgery: ICG Imaging Study

We are exploring how a special imaging technique using ICG dye can help surgeons evaluate cancer margins during breast-conserving surgery. This study aims to find the best timing and dose for the dye to improve surgical outcomes.

Early Invasive Breast Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesGynecology and ObstetricsOncology

[18F]PSMA-1007 PET/CT Imaging for Prostate Cancer

We are studying how well a new imaging method detects cancer spread in patients with newly diagnosed high-risk prostate cancer. This could help improve diagnosis and treatment planning.

Prostate Cancer>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesOncology

Botulinumtoxin A for Myofascial Pain in Temporomandibular Disorders

We are studying whether BTX injections in jaw muscles can effectively reduce pain in patients with temporomandibular disorders. This research may help improve treatment options for those suffering from this condition.

Temporomandibular DisorderConfirmation phase (III)No PlaceboStandard MedicinesOrthopedics and TraumatologyOtolaryngology

Guselkumab for Crohn's Disease Healing

We are studying whether guselkumab can help heal the intestinal wall in patients with Crohn's disease. This research aims to find out how effective it is over 48 weeks.

Crohn's Disease>2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteGastroenterologyInternal Medicine

Dapagliflozin for Heart Health in Amyloid Transthyretin Cardiac Amyloidosis

We are studying how dapagliflozin may improve exercise capacity and quality of life for patients with ATTR-CA. This trial will also look at its safety and other health markers.

Cardiac Amyloidosis1-2 yearsEfficacy phase (II)No PlaceboStandard MedicinesCardiologyInternal Medicine

Chronic Lymphocytic Leukemia: Tailored Ibrutinib Treatment

We are studying how personalized dosing of ibrutinib can improve treatment for patients with previously untreated chronic lymphocytic leukemia. The goal is to see if adjusting the dose based on side effects leads to better outcomes.

Chronic Lymphocytic Leukemia (CLL)Efficacy phase (II)No PlaceboInvestigational MedicinesHematologyOncology

Advanced Prostate Cancer: JNJ-87189401 and JNJ-78278343

We are exploring the safety of a new combination of medications for patients with advanced prostate cancer. This study aims to find out how well these drugs work together.

Advanced Prostate Cancer>2 yearsSafety phase (I)Oncology

LiBRA: Lithium for Cognitive Protection After Brain Radiotherapy

We are studying whether lithium can help prevent cognitive problems in children who received brain radiotherapy for cancer. The trial also looks at overall quality of life and safety of the treatment.

Brain Tumor3-6 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesNeurologyOncology

Personalized Anti-Platelet Therapy for Coronary Artery Disease

We are studying whether a genetic test-guided treatment improves blood platelet function in patients with stable coronary artery disease undergoing stenting. This may help determine the best anti-platelet therapy for individual patients.

Stable Coronary Artery DiseaseChronic Coronary Syndrome3-6 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesCardiologyInternal Medicine