Search Clinical Trials in the European Union

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81-100 of 240 trials

Bipolar Depression: Esketamine Nasal Spray

We are studying the safety and effectiveness of esketamine nasal spray for people with treatment-resistant bipolar depression. This trial aims to gather important information that could lead to future studies.

Bipolar Disorder - Depressive Episode≤3 monthsEfficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesPsychiatry

Fragile X Syndrome: Long-Term Study of ZYN002 Gel

We are examining the long-term safety and tolerability of a gel medication for children and young adults with Fragile X Syndrome. This study includes participants who have previously used the medication and are continuing to see if it helps manage their symptoms.

Fragile X Syndrome≤3 monthsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteInternal MedicineNeurologyPediatrics

Cushing’s Syndrome: Fluasterone Buccal Tablet

We are studying whether fluasterone can help control high blood sugar in adults with Cushing’s syndrome. The trial will also look at its safety and effects on weight and cholesterol levels.

Cushing's Syndrome≤3 monthsEfficacy phase (II)Investigational MedicinesDiabetologyEndocrinologyInternal Medicine

OXYTAHANE: Oxygen Therapy for Dystonic Attacks in Children

We are studying whether high-flow oxygen can help reduce acute dystonic and plegic attacks in children with alternating hemiplegia. The trial also looks at the impact on quality of life for both patients and caregivers.

Alternating Hemiplegia of Childhood≤3 monthsEfficacy phase (II)Standard MedicinesNeurologyPulmonology

Whooping Cough Vaccine: Tdap-IPV Study

We are studying whether a booster shot of the Tdap-IPV vaccine helps prevent colonization by whooping cough bacteria in healthy adults after exposure. This research aims to improve vaccination strategies against whooping cough.

Whooping Cough≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteInfectious Diseases

Obstructive Sleep Apnea: Nacystelyn Inhaler Study

We are testing a new inhaler treatment for people with obstructive sleep apnea to see if it helps improve symptoms and reduce oxidative stress. The study also looks at the safety of this new treatment.

Obstructive Sleep Apnea≤3 monthsEfficacy phase (II)≤5 visitsStandard MedicinesCost ReimbursementNeurologyPsychiatryPulmonology

Gabapentin for Nerve Pain in the Leg

We are studying whether gabapentin can reduce leg pain from lower back issues compared to a placebo. The trial also examines its effects on disability, work return, and mental health.

Radicular Leg Pain≤3 monthsConfirmation phase (III)Standard MedicinesNeurologyOrthopedics and Traumatology

Kidney Health in Type 2 Diabetes: Empagliflozin and Finerenone Study

We are exploring how well two medications work for kidney health in people with type 2 diabetes. This remote trial aims to personalize treatment based on individual responses.

Type 2 DiabetesAlbuminuria≤3 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesPartially RemoteDiabetologyInternal MedicineNephrology

Hyponatremia: Empagliflozin Treatment Study

We are investigating whether empagliflozin can help increase sodium levels in patients with euvolemic or hypervolemic hyponatremia. The study will also look at its effects on related symptoms and overall health.

Low Sodium Levels (Hyponatremia)≤3 monthsEfficacy phase (II)≤5 visitsStandard MedicinesEndocrinologyInternal Medicine

Melanoma Treatment: LTX-315 and Pembrolizumab

We are studying a new treatment combination for patients with resectable stage III-IV melanoma. The goal is to see how well it shrinks tumors and affects overall health and quality of life.

Stage III Malignant Melanoma≤3 monthsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesDermatologyOncology

Vulvar Cancer: Chemoradiation Study

We are investigating if chemoradiation alone is a safe alternative to surgery for early-stage vulvar cancer patients with lymph node involvement. The study also evaluates the side effects of this treatment over time.

Vulvar Cancer≤3 monthsEfficacy phase (II)No PlaceboStandard MedicinesGynecology and ObstetricsOncology

Breast Cancer: GR1014 Gel for Radiation Skin Protection

We are studying whether GR1014 gel can help prevent skin damage during radiation therapy for localized breast cancer after lumpectomy. This trial compares the gel to a standard treatment to see which is more effective.

Radiation-Induced Dermatitis≤3 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesDermatologyOncology

Prednisolone Transfer in Breast Milk: A Study for Breastfeeding Mothers

We are investigating how prednisolone, used for inflammation, transfers into breast milk and affects breastfeeding infants. This study aims to measure medication levels in both mothers and their babies to ensure safety.

Rheumatoid ArthritisSystemic Lupus ErythematosusMyositis≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicinePediatrics

Sotagliflozin for Post-Bariatric Hypoglycaemia

We are studying whether sotagliflozin can help people who have low blood sugar after weight loss surgery. Participants will receive either the medication or a placebo to compare effects on blood sugar levels.

Postbariatric Hypoglycemia≤3 monthsEfficacy phase (II)≤5 visitsInvestigational MedicinesCost ReimbursementEndocrinologyInternal Medicine

Lobular Breast Cancer: Capivasertib and Fulvestrant Study

We are studying a new treatment combination for patients with high-risk lobular breast cancer to see if it improves cancer control and safety compared to standard therapy.

Invasive Lobular Breast Carcinoma≤3 monthsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Preventing Opioid-Induced Constipation in Advanced Cancer Patients

We are comparing two laxatives to see which one better prevents constipation in patients with advanced cancer starting opioid pain treatment. This study will also assess quality of life and side effects.

Advanced Cancer≤3 monthsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOncology

Constipation Prevention in Critically Ill Children: PEG3350+E Treatment

We are studying whether a special solution can help prevent constipation in critically ill children. The trial also looks at the safety of this treatment and compares stool consistency in different patient groups.

Constipation≤3 monthsConfirmation phase (III)No PlaceboStandard MedicinesGastroenterologyPediatrics

Multiple Myeloma: Mezigdomide vs. Pomalidomide

We are studying whether a new drug, mezigdomide, combined with bortezomib and dexamethasone, is more effective than pomalidomide with the same drugs for patients with relapsed or refractory multiple myeloma.

Relapsed or Refractory Multiple Myeloma≤3 monthsConfirmation phase (III)>20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementHematologyOncology

Lower Limb Trauma: Rivaroxaban vs. Heparin

We are studying whether Rivaroxaban is as effective as low-molecular weight heparin in preventing blood clots in patients with lower limb injuries. This trial is for those at high risk of complications while in a cast or brace.

Lower Limb Trauma Requiring Immobilization≤3 monthsConfirmation phase (III)No PlaceboInvestigational MedicinesCardiologyOrthopedics and Traumatology

Oocyte Cryopreservation: Random Start Ovarian Stimulation

We are comparing a new method of ovarian stimulation with a traditional approach for women planning to freeze their eggs. This study aims to determine if the new method is equally effective.

Prevention of Female Infertility≤3 monthsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesEndocrinologyGynecology and Obstetrics