Search Clinical Trials in the European Union

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Confirmation phase (III)
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1181-1200 of 1,307 trials

Plozasiran for Severe Hypertriglyceridemia: SHASTA-5 Study

We are studying whether plozasiran can help adults with severe hypertriglyceridemia reduce their triglyceride levels and lower the risk of acute pancreatitis. The trial also looks at the treatment's safety and how it affects patients' overall health.

High Triglycerides>2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteEndocrinologyGastroenterology

Ketamine Therapy for Obsessive-Compulsive Disorder

We are studying whether ketamine can effectively reduce symptoms of obsessive-compulsive disorder. This trial will help us understand its impact on mental function during stressful situations.

Obsessive Compulsive Disorder (OCD)≤3 monthsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemotePsychiatry

Heart Failure Treatment: Sacubitril/Valsartan vs. Ramipril

We are studying how two heart medications affect heart function in patients with ischemic heart failure. Our goal is to see which treatment better helps improve heart structure and performance.

Congestive Heart Failure1-2 yearsConfirmation phase (III)Standard MedicinesCardiologyInternal Medicine

Zinc Acexamate for Advanced Chronic Liver Disease

We are studying whether Zinc Acexamate can improve health outcomes for patients with advanced chronic liver disease. This trial compares its effects to a placebo to see if it reduces complications and improves survival.

Advanced Chronic Liver Disease>2 yearsConfirmation phase (III)Standard MedicinesHepatologyInternal Medicine

Fecal Incontinence: ICEF15 Therapy

We are testing a new treatment for fecal incontinence caused by anal sphincter weakness. The study aims to see if this therapy improves symptoms and enhances quality of life for patients.

Fecal Incontinence1-2 yearsConfirmation phase (III)6-10 visitsInvestigational MedicinesPartially RemoteGastroenterology

Acute Myeloid Leukemia: NOPHO-DBH AML 2012 Study

We are researching new treatment options for children and adolescents with acute myeloid leukemia. The goal is to find more effective therapies while reducing side effects and improving overall outcomes.

Acute Myeloid Leukemia>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncologyPediatrics

Psychiatric Disorders: Immunotherapy Study

We are testing whether immunotherapy can help patients with psychotic symptoms and autoimmune conditions when added to their ongoing psychiatric care. This study aims to improve understanding of treatment options for these patients.

Mental Disorder1-2 yearsConfirmation phase (III)No PlaceboStandard MedicinesPsychiatry

Crohn’s Disease: Tulisokibart Treatment Study

We are testing a new medication, tulisokibart, for people with moderately to severely active Crohn’s disease. The goal is to see if it helps achieve remission and improve symptoms compared to a placebo.

Crohn's Disease>2 yearsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteGastroenterology

Advanced GEP-NET: [177Lu]Lu-DOTA-TATE Treatment Study

We are testing a new treatment combining [177Lu]Lu-DOTA-TATE and octreotide LAR for patients with advanced Grade 1 and Grade 2 GEP-NET. The goal is to see if it can better delay disease progression and improve quality of life compared to existing therapies.

Gastroenteropancreatic Neuroendocrine Tumors1-2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesOncology

Transthyretin Amyloidosis with Cardiomyopathy: Vutrisiran Study

We are evaluating the safety and effectiveness of vutrisiran in patients with transthyretin amyloidosis and heart issues. This study includes those continuing treatment or switching from another medication.

Cardiac Amyloidosis>2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementCardiologyInternal Medicine

Fertility Study: Metformin for Women Post-Thyroid Cancer

We are evaluating whether metformin can improve fertility in women treated with radioactive iodine for thyroid cancer. The study will look at hormone levels and ovarian health to see how effective the treatment is.

Papillary Thyroid Carcinoma1-2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesGynecology and ObstetricsOncology

Acute Myeloid Leukemia: L-Annamycin with Cytarabine

We are studying a new treatment combining L-Annamycin with Cytarabine for adults with difficult-to-treat acute myeloid leukemia. The goal is to see if this combination can help achieve remission better than a placebo.

Acute Myeloid Leukemia>2 yearsEfficacy phase (II)Confirmation phase (III)6-10 visitsInvestigational MedicinesCost ReimbursementPartially RemoteOncology

Lung Cancer Treatment: Divarasib and Pembrolizumab

We are studying a new treatment combination for patients with advanced non-small cell lung cancer that has a specific genetic mutation. The goal is to see if this new approach improves survival and quality of life compared to standard treatments.

Advanced Non-Squamous Non-Small Cell Lung Cancer1-2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementOncology

Wiskott-Aldrich Syndrome: Long-term Study of Gene Therapy

We are examining the long-term safety and effectiveness of a gene therapy treatment for individuals with Wiskott-Aldrich Syndrome. This study aims to provide insights into how well the treatment works over time.

Wiskott-Aldrich Syndrome>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesPartially RemoteHematologyInfectious Diseases

Leber Congenital Amaurosis: Sepofarsen Treatment Study

We are investigating a new treatment for people with Leber Congenital Amaurosis caused by a specific genetic mutation. The study will assess how well it improves vision and its safety over time.

Leber's Congenital Amaurosis>2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesOphthalmology

Breast MRI: Low-Dose Gadolinium Study

We are testing whether a lower dose of gadolinium in breast MRI can provide image quality similar to the standard dose. This may help reduce contrast exposure while maintaining diagnostic accuracy.

Breast Cancer1-2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboInvestigational MedicinesInternal MedicineOncologyOtolaryngology

Mycobacterium Avium Complex Lung Infections: Comparing Antibiotics

We are studying whether azithromycin is as effective as clarithromycin for treating lung infections caused by Mycobacterium avium complex. The trial also examines safety and side effects of both treatments.

Mycobacterium Avium Complex Infection>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesInfectious DiseasesPulmonology

Lung Cancer Treatment: Telisotuzumab Adizutecan with Osimertinib

We are studying a new combination treatment for adults with advanced EGFR-mutated non-small cell lung cancer. The goal is to see if this approach is safer and more effective than current standard treatments.

Non-Small Cell Lung Cancer6-12 monthsEfficacy phase (II)Confirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementOncology

Hydroxychloroquine for Mastocytosis Symptoms

We are studying whether hydroxychloroquine can help reduce itching and flushing in patients with isolated cutaneous mastocytosis or indolent systemic mastocytosis with skin involvement. The trial also looks at other symptoms and how well patients tolerate the treatment.

Mastocytosis>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesDermatologyInternal Medicine

Ulcerative Colitis: MK-7240 Treatment Study

We are studying MK-7240 to see if it helps people with moderately to severely active ulcerative colitis achieve remission. The trial will also evaluate the safety and effectiveness of this new treatment compared to a placebo.

Ulcerative Colitis1-2 yearsConfirmation phase (III)Monitoring phase (IV)16-20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementGastroenterology