Search Clinical Trials in the European Union

>2 years
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1241-1260 of 1,743 trials

Leukemia: Venetoclax with Stem Cell Transplant

We are evaluating the safety and effectiveness of Venetoclax combined with standard treatment for patients with high-risk MDS, CMML, or sAML undergoing stem cell transplantation. This study aims to improve outcomes and reduce complications during treatment.

Leukemia>2 yearsSafety phase (I)Efficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesHematologyOncology

Ulcerative Colitis in Kids: Risankizumab Study

We are evaluating how well Risankizumab works and its safety for children aged 2 to under 18 with moderately to severely active ulcerative colitis. This study will help us understand how the drug is processed in their bodies.

Ulcerative Colitis>2 yearsConfirmation phase (III)>20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementGastroenterologyPediatrics

Antibiotic Treatment for Critically Ill Patients

We are studying whether a short course of high-dose antibiotics is as effective as standard treatment for critically ill patients with pneumonia, intra-abdominal infections, or bloodstream infections. This research may help reduce antibiotic use while maintaining patient safety.

Pneumonia and Bacterial Infections>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteInfectious DiseasesInternal Medicine

Gout Treatment: Prednisolone vs. Colchicine

We are comparing two medications for treating acute gout attacks to see which one provides better pain relief and improves joint function. This study aims to help patients find more effective treatment options.

Gout>2 yearsMonitoring phase (IV)Standard MedicinesRheumatology

Advanced Solid Tumors: OMTX705 Treatment

We are testing a new antibody-drug conjugate for patients with advanced solid tumors. The study looks at its effects alone and in combination with another treatment to see how well it works.

Tumors Expressing Fibroblast Activation Protein (FAP)>2 yearsSafety phase (I)Oncology

Psoriasis: [18F]Fluoride PET-CT Imaging Study

We are investigating if [18F]Fluoride PET-CT scans can detect early bone changes in psoriasis patients at risk for psoriatic arthritis. This study aims to see if this imaging method is effective for early detection.

Psoriasis>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementDermatologyRheumatology

Colorectal Cancer Prevention: Mesalamine for Lynch Syndrome

We are studying whether mesalamine can help prevent colorectal cancer in patients with Lynch syndrome. This trial compares mesalamine to a placebo to see if it reduces the occurrence of tumors.

Lynch Syndrome>2 yearsEfficacy phase (II)≤5 visitsStandard MedicinesPartially RemoteGastroenterologyOncology

Gastroenteropancreatic Neuroendocrine Tumors: New Liver Treatment

We are studying a new way to deliver radiolabeled treatments directly to the liver for patients with GEP-NET and dominant liver metastases. This trial aims to see if this method improves treatment effectiveness and safety.

Gastroenteropancreatic Neuroendocrine Tumors>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementGastroenterologyInternal MedicineOncology

Prostate Cancer: Enzalutamide Study

We are investigating how Enzalutamide affects molecular changes in men with localized prostate cancer before and after surgery. This study may help us understand its impact on cell growth and gene activity.

Prostate Cancer>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOncologyUrology

Relapsed or Refractory Tumors: AcSé-ESMART Trial

We are studying new treatment options for children and adolescents with hard-to-treat tumors. The goal is to see if these treatments are safe and effective based on the specific characteristics of their tumors.

Pediatric Cancer>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesOncologyPediatrics

Kidney Transplant: Optimal Dose of Grafalon®

We are studying the best dose of Grafalon® for kidney transplant patients with low immunological risk. This trial aims to prevent complications and evaluate the medication's safety and effects on kidney function and infections.

Kidney TransplantKidney Insufficiency>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesInternal MedicineNephrology

Post-Surgery Pain Management: Ropivacaine Concentration Study

We are investigating whether different concentrations of ropivacaine can help reduce pain after volar plate surgery. This study aims to see if higher doses lead to less rebound pain and better overall pain control.

Radius Fracture>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteOrthopedics and TraumatologyOtolaryngologyPsychiatry

Ovarian Cancer: Rinatabart Sesutecan (Rina-S) Study

We are comparing a new treatment, Rina-S, to standard therapies for patients with platinum-resistant ovarian cancer. The goal is to see if Rina-S can help improve survival without disease progression.

Platinum-resistant Ovarian Cancer>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesOncology

Chronic Lymphocytic Leukemia: Ibrutinib and Obinutuzumab Treatment

We are studying a combination of ibrutinib and obinutuzumab for newly diagnosed patients with Chronic Lymphocytic Leukemia. The aim is to see if this treatment effectively reduces cancer cells in the bone marrow.

Chronic Lymphocytic Leukemia (CLL)>2 yearsEfficacy phase (II)>20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Rectal Cancer: Ferumoxtran-10 MRI Study

We are testing a new MRI method to see if it better identifies lymph node involvement in patients with newly diagnosed rectal cancer. This may help doctors plan more effective treatments.

Rectal CancerMesorectal Lymph Node Metastases>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncologyOtolaryngology

Severe Asthma: Predicting Response to Benralizumab

We are studying whether early blood tests can predict how well severe asthma patients respond to Benralizumab treatment. This may help identify those who are likely to experience fewer asthma attacks.

Severe Asthma>2 yearsMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteAllergologyPulmonology

Unilateral Retinoblastoma: Adjuvant Treatment Study

We are studying additional treatments for patients with unilateral retinoblastoma after eye removal. The goal is to understand how these treatments affect recovery and any potential side effects.

Retinoblastoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyOphthalmology

Ensifentrine for Non-Cystic Fibrosis Bronchiectasis

We are studying whether nebulized ensifentrine can help reduce lung flare-ups in people with non-cystic fibrosis bronchiectasis. The trial also examines its impact on respiratory symptoms and overall quality of life.

Non-Cystic Fibrosis Bronchiectasis>2 yearsEfficacy phase (II)≤5 visitsInvestigational MedicinesPulmonology

Preventing Abscesses After Appendicitis Surgery: ALPACA Trial

We are studying if a special antibiotic wash during surgery can lower the risk of abscesses in patients with complicated appendicitis. This trial aims to improve recovery and reduce complications after surgery.

Appendicitis>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesGastroenterologyInfectious DiseasesOrthopedics and Traumatology

Scoliosis Surgery: Pooled Plasma vs. Crystalloid

We are studying whether pooled human plasma can reduce blood loss during spinal fusion surgery in children with scoliosis compared to a standard fluid. This trial aims to improve fluid management during surgery.

Neuromuscular ScoliosisAdolescent Idiopathic Scoliosis>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesOrthopedics and TraumatologyPediatrics