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1361-1380 of 3,900 trials

Early-Onset Alzheimer's Disease: ALN-APP Treatment

We are evaluating the safety and tolerability of a new treatment called ALN-APP for patients with early-onset Alzheimer's disease. This study aims to understand how well the treatment is tolerated in humans.

Early-onset Alzheimer's DiseaseSafety phase (I)Neurology

Renal Lifecycle Trial: Dapagliflozin for Severe Chronic Kidney Disease

We are studying whether dapagliflozin can improve kidney and heart health in patients with severe chronic kidney disease. This includes those on dialysis and kidney transplant recipients.

Healthy Participants>2 yearsConfirmation phase (III)6-10 visitsInvestigational MedicinesCardiologyNephrology

Inflammatory Bowel Disease: Adalimumab-680LT Study

We are investigating the safety and imaging of a new version of adalimumab for people with inflammatory bowel diseases. This study aims to see how well the drug targets inflammation and its potential effects on health.

Inflammatory Bowel Disease (IBD)6-12 monthsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesGastroenterologyInfectious Diseases

Meningioma Treatment: Everolimus and 177Lu-DOTATATE

We are studying a new combination treatment for patients with grades 2 and 3 refractory meningioma. The goal is to see if this approach can help improve survival and manage tumor growth.

Malignant Meningiomas1-2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteNeurologyOncology

OXYTAHANE: Oxygen Therapy for Dystonic Attacks in Children

We are studying whether high-flow oxygen can help reduce acute dystonic and plegic attacks in children with alternating hemiplegia. The trial also looks at the impact on quality of life for both patients and caregivers.

Alternating Hemiplegia of Childhood≤3 monthsEfficacy phase (II)Standard MedicinesNeurologyPulmonology

Whooping Cough Vaccine: Tdap-IPV Study

We are studying whether a booster shot of the Tdap-IPV vaccine helps prevent colonization by whooping cough bacteria in healthy adults after exposure. This research aims to improve vaccination strategies against whooping cough.

Whooping Cough≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteInfectious Diseases

Chronic Pelvic Pain: Esketamine Infusion Study

We are investigating whether an 8-hour infusion of esketamine can help reduce chronic pelvic pain in individuals with endometriosis. The study also examines treatment experiences and overall quality of life.

EndometriosisMonitoring phase (IV)Standard MedicinesGynecology and ObstetricsPsychiatry

Head and Neck Cancer: Amivantamab Treatment Study

We are studying the effects of amivantamab in patients with recurrent or metastatic head and neck squamous cell carcinoma. This trial looks at its use alone and with other standard treatments to see how well it works.

Recurrent Head and Neck CancerSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteOncology

B-cell Acute Lymphoblastic Leukemia: CD19-CAR T Cell Therapy

We are testing a new type of CAR T cell therapy for children and young adults with relapsed or refractory B-cell acute lymphoblastic leukemia. The study aims to evaluate the safety and appropriate dosage of this treatment.

Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia>2 yearsSafety phase (I)No PlaceboInvestigational MedicinesHematologyOncology

Chronic Lymphocytic Leukemia: Acalabrutinib vs. Venetoclax

We are comparing two treatment combinations for newly diagnosed chronic lymphocytic leukemia patients to see which is more effective and safer. We will also look at how these treatments affect patients' quality of life.

Chronic Lymphocytic Leukemia>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesHematologyOncology

Nipocalimab for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

We are studying whether nipocalimab can help adults with CIDP delay relapse and improve their symptoms compared to a placebo. This trial will also assess the safety of the treatment.

Chronic Inflammatory Demyelinating PolyneuropathyEfficacy phase (II)Post-Trial Drug AccessInvestigational MedicinesPartially RemoteNeurology

Progressive Pulmonary Fibrosis: Inhaled Pirfenidone Study

We are testing an inhaled medication to see if it helps improve lung function and quality of life for people with Progressive Pulmonary Fibrosis. This study compares the medication to a placebo to assess its effects over time.

Progressive Pulmonary Fibrosis1-2 yearsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessStandard MedicinesPulmonology

Scleroderma: Stem Cell Injections for Digital Ulcers

We are studying if injections of cultured fat cells can help heal stubborn digital ulcers in patients with scleroderma. This trial compares the treatment to a placebo to evaluate its effectiveness and safety.

Systemic Sclerosis>2 yearsEfficacy phase (II)6-10 visitsInvestigational MedicinesCost ReimbursementInternal MedicineRheumatology

Breast Cancer: Study of OKI-219 Treatment

We are investigating a new treatment called OKI-219 for patients with breast cancer. This study looks at how it works alone and with other therapies to improve outcomes.

Advanced Breast CancerSolid Tumor>2 yearsSafety phase (I)Oncology

Gastrointestinal Tolerability: Tegomil vs. Dimethyl Fumarate

We are comparing how well healthy volunteers tolerate two oral medications for gastrointestinal side effects. This study aims to understand which option may be easier on the stomach.

Multiple Sclerosis3-6 monthsSafety phase (I)Neurology

Hepatitis B: SAMBA Study on Antibodies

We are investigating the safety and effects of new antibodies for people with hepatitis B. This study aims to learn more about how these treatments may help manage the disease.

Chronic Hepatitis BSafety phase (I)HepatologyInfectious Diseases

Obstructive Sleep Apnea: Nacystelyn Inhaler Study

We are testing a new inhaler treatment for people with obstructive sleep apnea to see if it helps improve symptoms and reduce oxidative stress. The study also looks at the safety of this new treatment.

Obstructive Sleep Apnea≤3 monthsEfficacy phase (II)≤5 visitsStandard MedicinesCost ReimbursementNeurologyPsychiatryPulmonology

Stroke Treatment Study: Tirofiban vs. Aspirin

We are comparing the effectiveness and safety of tirofiban and aspirin for patients with acute ischemic stroke caused by tandem lesions. This study aims to find out which treatment better prevents complications and improves recovery.

Acute Ischemic Stroke>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyNeurology

Hyperkalaemia in Children: SZC Treatment Study

We are studying whether the medication SZC can safely normalize potassium levels in children with hyperkalaemia. The trial will also check how well it maintains these levels over time.

High Potassium Levels (Hyperkalemia)6-12 monthsConfirmation phase (III)16-20 visitsNo PlaceboInvestigational MedicinesCost ReimbursementNephrologyPediatrics

Advanced Solid Tumors: Sigvotatug Vedotin

We are studying a new treatment for patients with advanced solid tumors to see how well it works compared to current options. This research aims to improve outcomes for those affected by these cancers.

Cervical CancerHead and Neck CancerGastric Cancer>2 yearsSafety phase (I)Oncology