Search Clinical Trials in the European Union

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1581-1600 of 1,738 trials

Breast Cancer: Inavolisib Treatment Study

We are testing a new treatment using Inavolisib for patients with early-stage, PIK3CA-mutated breast cancer. The study aims to evaluate how safe and effective this treatment is for participants.

Early-Stage Breast Cancer6-12 monthsEfficacy phase (II)11-15 visitsNo PlaceboInvestigational MedicinesPartially RemoteOncology

Advanced Non-Small Cell Lung Cancer: Cemiplimab Treatment Study

We are investigating whether treatment decisions based on blood tests for tumor DNA improve outcomes for patients with advanced non-small cell lung cancer. This includes testing Cemiplimab alone or with chemotherapy.

Non-small Cell Lung Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Triple-Negative Breast Cancer: Dato-DXd Treatment

We are studying a new drug for patients with triple-negative breast cancer and brain metastases to see if it can help shrink tumors and improve survival. The trial also examines safety and quality of life for participants.

Triple Negative Breast Cancer>2 yearsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesNeurologyOncology

Blood Cancers: Sonrotoclax Safety Study

We are investigating new dosing schedules for Sonrotoclax in adults with blood cancers. The study aims to understand the safety and tolerability of this treatment approach.

Chronic Lymphocytic LeukemiaSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesHematologyOncology

Dapansutrile Tablets for Acute Gout Flare

We are studying whether dapansutrile can reduce joint pain and other symptoms in people experiencing an acute gout flare. This trial compares the medication to a placebo to assess its effectiveness and safety.

Gout Flare≤3 monthsEfficacy phase (II)Confirmation phase (III)Investigational MedicinesInternal MedicineRheumatology

Kidney Protection: Cilastatin vs. Thiosulfate

We are comparing cilastatin and thiosulfate to see which better protects kidneys during surgery with chemotherapy for cancer patients. This study aims to reduce kidney damage after the procedure.

Acute Kidney Injury>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesInternal MedicineNephrologyOncology

Palmoplantar Pustulosis: Delgocitinib Cream Study

We are investigating whether delgocitinib cream can effectively treat adults with mild to severe palmoplantar pustulosis compared to a dummy cream. The study will also assess the safety and impact on quality of life.

Palmoplantar Pustulosis3-6 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesDermatology

Cushing's Disease: Silycus® Treatment Study

We are studying the effects of Silycus® on lowering cortisol levels in patients with Cushing's disease. The trial will also evaluate how well patients tolerate the treatment and its impact on their symptoms.

Cushing's Disease1-2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesEndocrinology

HIV Treatment: Venetoclax Study

We are testing the safety of a medication called venetoclax in people living with HIV who are on antiretroviral therapy. The aim is to see if it can help reduce the size of the HIV reservoir in the body.

HIV-1 Disease1-2 yearsSafety phase (I)Efficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesPartially RemoteHematologyInfectious Diseases

Malaria Prevention: Atovaquone-Proguanil Study

We are testing a weekly dose of atovaquone-proguanil to see if it can prevent malaria in healthy volunteers. The study also looks at the safety of the medication and how it behaves in the body.

Malaria6-12 monthsEfficacy phase (II)16-20 visitsInvestigational MedicinesInfectious Diseases

Nintedanib for Nosebleeds in Hereditary Hemorrhagic Telangiectasia

We are studying whether nintedanib can help reduce the duration of nosebleeds in patients with hereditary hemorrhagic telangiectasia. The trial also examines its effects on quality of life and potential side effects.

Hereditary Hemorrhagic Telangiectasia1-2 yearsEfficacy phase (II)6-10 visitsStandard MedicinesHematologyInternal Medicine

Neural Stem Cell Treatment for Amyotrophic Lateral Sclerosis

We are studying a new treatment using neural stem cells for people with ALS. The trial aims to assess safety and whether it may help slow disease progression.

Amyotrophic Lateral Sclerosis>2 yearsEfficacy phase (II)6-10 visitsStandard MedicinesNeurology

Vitamin D3 for Healing After Wisdom Tooth Removal

We are studying whether high doses of vitamin D3 can improve soft tissue healing after wisdom tooth extraction. We’ll also look at how it affects inflammation during recovery.

Vitamin D Insufficiency Related to Tooth Extraction1-2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesOrthopedics and TraumatologyOtolaryngologyPediatrics

BCG Vaccine for Radiologically Isolated Syndrome (RIS)

We are studying whether the BCG vaccine can help reduce new brain lesions in people diagnosed with Radiologically Isolated Syndrome. The trial also looks at the safety of the vaccine and other brain changes over time.

Radiologically Isolated Syndrome>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesInfectious DiseasesNeurology

Ulcerative Colitis and Crohn’s Disease: Long-term Study of Zasocitinib

We are investigating the long-term safety and effectiveness of oral zasocitinib in adults with moderately to severely active ulcerative colitis and Crohn’s disease. This study is for those who have responded to treatment in previous trials.

Ulcerative ColitisCrohn's Disease>2 yearsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementGastroenterologyInternal Medicine

Knee Osteoarthritis: Study of 4P004 Treatment

We are investigating whether the treatment 4P004 can reduce pain and improve function in people with knee synovitis and osteoarthritis. Participants will receive either the treatment or a placebo to assess its effectiveness and safety.

Knee Synovitis and Osteoarthritis≤3 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesPartially RemoteOrthopedics and TraumatologyRheumatology

Cannabinoids for Quality of Life in Cancer Patients

We are studying whether a cannabinoid solution can improve symptoms and overall well-being in patients with cancer. This trial compares its effects to a placebo to gather important data for future research.

Healthy Participants≤3 monthsEfficacy phase (II)Investigational MedicinesInternal MedicineOncology

Narcolepsy and Idiopathic Hypersomnia: ORX750 Study

We are testing a new medication, ORX750, to see if it is safe and well-tolerated in people with narcolepsy and idiopathic hypersomnia. This study will help us understand how the drug works in the body.

Narcolepsy with CataplexyIdiopathic Hypersomnia3-6 monthsEfficacy phase (II)≤5 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteNeurology

Bladder Cancer: New Treatment Combination Study

We are investigating a new treatment combining chemotherapy and immunotherapy with radiotherapy for patients with non-metastatic muscle invasive bladder cancer. The goal is to see if this approach improves survival and quality of life after surgery.

Non-Metastatic Muscle Invasive Bladder Cancer1-2 yearsEfficacy phase (II)16-20 visitsNo PlaceboStandard MedicinesOncologyUrology

Pancreatic Cancer: Nabpaclitaxel Chemotherapy Study

We are studying a new combination of chemotherapy treatments for patients with pancreatic cancer that has spread to the abdominal lining. The goal is to see if this approach can help shrink tumors and improve survival.

Pancreatic Cancer with Peritoneal MetastasesEfficacy phase (II)No PlaceboStandard MedicinesGastroenterologyOncology