Search Clinical Trials in the European Union

Duration
Visits
Phase
Intake methods
No Placebo
Drugs
Locations
Clinical Specialty
2041-2060 of 2,251 trials

Bloodstream Infections: PipEracillin Tazobactam vs. Meropenem

We are studying whether PipEracillin Tazobactam is as effective as Meropenem for treating bloodstream infections caused by certain resistant bacteria. This trial is for patients with infections from these specific bacteria.

Bacteremia1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

Lung Cancer Treatment: Telisotuzumab Adizutecan with Osimertinib

We are studying a new combination treatment for adults with advanced EGFR-mutated non-small cell lung cancer. The goal is to see if this approach is safer and more effective than current standard treatments.

Non-Small Cell Lung Cancer6-12 monthsEfficacy phase (II)Confirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementOncology

Hydroxychloroquine for Mastocytosis Symptoms

We are studying whether hydroxychloroquine can help reduce itching and flushing in patients with isolated cutaneous mastocytosis or indolent systemic mastocytosis with skin involvement. The trial also looks at other symptoms and how well patients tolerate the treatment.

Mastocytosis>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesDermatologyInternal Medicine

Nebivolol for High Blood Pressure in Teens

We are studying how well Nebivolol works to lower blood pressure in adolescents with hypertension. The trial will also look at the safety of this medication during treatment.

Juvenile Hypertension6-12 monthsConfirmation phase (III)No PlaceboStandard MedicinesCardiologyInternal Medicine

Prostate Cancer Treatment: Docetaxel vs. Androgen Receptor-targeted Agents

We are studying whether docetaxel is more effective than abiraterone or enzalutamide for men with advanced prostate cancer and specific negative prognostic factors. This research aims to improve treatment outcomes and quality of life.

Metastatic Castration-Resistant Prostate CancerMonitoring phase (IV)No PlaceboStandard MedicinesOncologyUrology

Gastroesophageal Cancer: Sertraline with Immunochemotherapy

We are studying whether adding sertraline can enhance treatment responses in patients with advanced gastroesophageal cancer receiving immunochemotherapy. The trial also looks at safety, quality of life, and depression during treatment.

Gastroesophageal Cancer>2 yearsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesOncologyPsychiatry

Advanced Non-Small Cell Lung Cancer: H1-Antihistamine with Immunotherapy

We are studying whether adding an H1-antihistamine to immunotherapy can improve treatment response in patients with advanced non-small cell lung cancer.

Advanced Non-Small Cell Lung Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesOncologyPulmonology

Cholangiocarcinoma: Chemo and Immunotherapy Study

We are exploring a combination of chemotherapy and immunotherapy for patients with locally advanced cholangiocarcinoma before surgery. The study aims to see if this approach can lower the risk of cancer returning after treatment.

Cholangiocarcinoma1-2 yearsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteOncology

Critical Limb Ischemia: L-PRF Treatment Study

We are investigating the safety of a new treatment using patient-derived fibrin for individuals with critical limb ischemia. The study also looks at its potential effects on limb health and quality of life.

Critical Limb Ischemia>2 yearsSafety phase (I)No PlaceboInvestigational MedicinesCardiologyInternal Medicine

Glioblastoma: Dendritic Cell Immunotherapy Study

We are evaluating a new immune therapy for patients with glioblastoma to see if it improves survival and quality of life compared to standard treatments.

Glioblastoma>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboInvestigational MedicinesOncology

Acute Cholecystitis: Indocyanine Green in Surgery

We are testing whether indocyanine green can help reduce surgery time and improve safety during gallbladder removal in patients with acute cholecystitis. This study aims to enhance surgical outcomes and patient satisfaction.

Acute Cholecystitis>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesGastroenterologyOrthopedics and Traumatology

Prostate Cancer: HIFU and Hormone Therapy Study

We are testing a combination of high-intensity focused ultrasound and short-term hormone therapy for men with intermediate-risk localized prostate cancer. The goal is to see if this approach improves cancer control and maintains sexual and urinary functions.

Intermediate Risk Prostate Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesOncologyUrology

Medication-Related Osteonecrosis of the Jaw: PENTO Treatment Study

We are investigating whether the PENTO treatment can help heal jaw bone exposure in patients with MRONJ. The study will also look at pain levels, nutrition, and any side effects over time.

Medication-Related Osteonecrosis of the Jaw>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesInternal MedicineOrthopedics and Traumatology

HIV-1 Reservoir Study: ITACO and ITACO-ATI

We are investigating how the HIV-1 virus behaves in patients with perinatal infections to find better treatment strategies. This study looks at the effects of temporarily stopping antiretroviral therapy and the immune responses involved.

Perinatal HIV InfectionConfirmation phase (III)No PlaceboStandard MedicinesInfectious Diseases

Anticoagulation Strategies for ECMO Support

We are comparing three blood-thinning medications to see which is safer and more effective for patients on ECMO. This study aims to reduce blood clots and bleeding risks during treatment.

Respiratory Failure and Insufficiency≤3 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCardiologyInternal Medicine

Metastatic Pancreatic Cancer: Valproic Acid and Simvastatin Study

We are studying whether adding valproic acid and simvastatin to standard chemotherapy improves treatment for patients with metastatic pancreatic cancer. This trial also looks at safety and quality of life for participants.

Metastatic Pancreatic CancerEfficacy phase (II)No PlaceboStandard MedicinesOncology

Apathy After Stroke: Brain Pathway Study

We are examining how cholinergic and dopaminergic systems relate to apathy in stroke patients. This study aims to understand the brain's role in apathy to improve future treatments.

ApathyStroke>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementNeurologyPsychiatry

Severe Acute Pain: ESKAPE Study on Low-Dose Ketamine

We are comparing two low-dose ketamine treatments for severe pain in the emergency department. The study looks at pain relief and any psychological effects patients may experience.

Severe Acute Pain>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOtolaryngologyPsychiatry

Colon Cancer: Chemotherapy Study for Older Adults

We are comparing two chemotherapy strategies for patients aged 70 and older who have had surgery for stage III colon cancer. The goal is to see which treatment helps prevent cancer from returning.

Colon Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Non-Small Cell Lung Cancer: New Treatment Study

We are testing new investigational treatments for patients with previously treated stage IV non-small cell lung cancer. The study aims to evaluate how well these treatments work and their safety.

Non-small Cell Lung Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology