Search Clinical Trials in the European Union

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641-660 of 1,782 trials

Progressive Pulmonary Fibrosis: Inhaled Pirfenidone Study

We are testing an inhaled medication to see if it helps improve lung function and quality of life for people with Progressive Pulmonary Fibrosis. This study compares the medication to a placebo to assess its effects over time.

Progressive Pulmonary Fibrosis1-2 yearsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessStandard MedicinesPulmonology

Obstructive Sleep Apnea: Nacystelyn Inhaler Study

We are testing a new inhaler treatment for people with obstructive sleep apnea to see if it helps improve symptoms and reduce oxidative stress. The study also looks at the safety of this new treatment.

Obstructive Sleep Apnea≤3 monthsEfficacy phase (II)≤5 visitsStandard MedicinesCost ReimbursementNeurologyPsychiatryPulmonology

Stroke Treatment Study: Tirofiban vs. Aspirin

We are comparing the effectiveness and safety of tirofiban and aspirin for patients with acute ischemic stroke caused by tandem lesions. This study aims to find out which treatment better prevents complications and improves recovery.

Acute Ischemic Stroke>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyNeurology

Advanced Epithelial Ovarian Cancer: Radspherin® Treatment

We are studying whether Radspherin® can improve survival and quality of life for patients with advanced ovarian cancer and peritoneal metastasis. This trial focuses on those scheduled for chemotherapy and surgery.

Peritoneal Carcinomatosis>2 yearsEfficacy phase (II)≤5 visitsStandard MedicinesCost ReimbursementPartially RemoteGynecology and ObstetricsOncology

Crohn's Disease: New Ultrasound Method with Microbubbles

We are testing a novel ultrasound technique using oral contrast to improve the detection of Crohn's disease complications. This study aims to see if it can identify issues like ulcers and blockages in the small intestine.

Crohn's Disease>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesGastroenterologyInternal Medicine

Alport Syndrome: Dapagliflozin for Kidney Health

We are studying whether Dapagliflozin can help slow the progression of kidney disease in adolescents and young adults with Alport syndrome. This trial aims to improve treatment options for those with this condition.

Alport's Syndrome>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesInternal MedicineNephrology

Seasonal Allergic Rhinitis: PQ Grass Treatment for Kids

We are studying a new treatment for children and teens with seasonal allergic rhinitis caused by grass pollen. The goal is to see if it helps reduce symptoms and is safe for long-term use.

Allergic Rhinitis and Conjunctivitis>2 yearsConfirmation phase (III)>20 visitsStandard MedicinesCost ReimbursementPartially RemoteAllergologyPediatrics

Coronary Artery Disease: Comparing Diabetes Medications

We are studying how well a new diabetes medication works to improve heart health in people with coronary artery disease and prediabetes. This trial compares a GLP-1 agonist and an SGLT-2 inhibitor to standard treatment.

Coronary Artery DiseasePrediabetesCoronary Atherosclerosis3-6 monthsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyEndocrinology

Mechanical Heart Valves: Lower INR Study

We are evaluating if a lower INR range is safer and more effective for patients with bileaflet aortic mechanical valves. This may help reduce bleeding risks associated with current treatment methods.

Aortic Valve Replacement Treatment>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesPartially RemoteCardiologyInternal Medicine

Ravulizumab for Children with NMOSD

We are studying the safety and effectiveness of Ravulizumab in children and adolescents with NMOSD. This trial aims to see how it affects their neurological function and overall quality of life.

Neuromyelitis Optica Spectrum Disorder1-2 yearsEfficacy phase (II)Confirmation phase (III)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteNeurologyPediatrics

Cirrhosis and Portal Hypertension: Metformin Study

We are investigating whether metformin can improve liver blood flow in patients with cirrhosis and portal hypertension. This study will also assess the safety of metformin and its effects on liver health.

Portal Hypertension1-2 yearsEfficacy phase (II)≤5 visitsStandard MedicinesHepatologyInternal Medicine

Gabapentin for Nerve Pain in the Leg

We are studying whether gabapentin can reduce leg pain from lower back issues compared to a placebo. The trial also examines its effects on disability, work return, and mental health.

Radicular Leg Pain≤3 monthsConfirmation phase (III)Standard MedicinesNeurologyOrthopedics and Traumatology

Tonsillitis Treatment: Antibiotic vs. No Treatment

We are studying whether an antibiotic can help reduce symptoms in patients with severe tonsillitis who test negative for Streptococcus group A. This trial compares the antibiotic to usual care without antibiotics.

Tonsilitis>2 yearsMonitoring phase (IV)Standard MedicinesInternal MedicineOtolaryngology

Multiple Myeloma: Treatment-Free Interval Study

We are exploring whether a treatment-free interval is safe and effective for newly diagnosed multiple myeloma patients receiving a combination of Daratumumab, Lenalidomide, and Dexamethasone. The study aims to compare the effects of continuous treatment versus a break in therapy.

Multiple Myeloma>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesHematologyOncology

Metastatic Breast Cancer: FDG-PET/CT vs. Conventional CT

We are studying whether FDG-PET/CT can better monitor treatment response in metastatic breast cancer patients compared to conventional CT. This may help improve survival and quality of life for those involved.

Metastatic Breast Cancer>2 yearsConfirmation phase (III)16-20 visitsNo PlaceboStandard MedicinesPartially RemoteOncology

Hyponatremia: Empagliflozin Treatment Study

We are investigating whether empagliflozin can help increase sodium levels in patients with euvolemic or hypervolemic hyponatremia. The study will also look at its effects on related symptoms and overall health.

Low Sodium Levels (Hyponatremia)≤3 monthsEfficacy phase (II)≤5 visitsStandard MedicinesEndocrinologyInternal Medicine

Graft-Versus-Host Disease: Corticosteroids with ECP

We are studying whether adding extracorporeal photopheresis to corticosteroids helps patients with Grade II acute graft-versus-host disease after stem cell transplantation. This trial compares treatment outcomes and side effects between the two approaches.

Acute Graft-Versus-Host Disease (GVHD)>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

BRAF V600E Mutated Metastatic Colorectal Cancer: ENCORAFENIB and FOLFIRI

We are studying a combination of ENCORAFENIB and FOLFIRI for patients with BRAF V600E mutated metastatic colorectal cancer that has progressed on previous treatments. The goal is to see if this combination can improve treatment outcomes and safety.

Colorectal Cancer1-2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

HIV Treatment Comparison: Doravirine vs. Dolutegravir

We are studying whether doravirine is as effective as dolutegravir for people newly diagnosed with HIV-1. The trial also examines potential side effects and health changes over time.

HIV Infection>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

HIV and HBV Co-Infection: Antiviral Treatment Strategies

We are studying two treatment reduction strategies for patients co-infected with HIV-1 and HBV to see how safely they can manage their viral infections. The trial will also look at the impact on quality of life and any potential side effects.

Co-infection with HIV-1 and HBV>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesHepatologyInfectious Diseases