Search Clinical Trials in the European Union

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41-60 of 525 trials

Rituximab for Amyotrophic Lateral Sclerosis (ALS)

We are studying whether adding Rituximab to standard treatment can slow symptom progression in ALS patients. The trial also monitors safety and various health indicators.

Sporadic Amyotrophic Lateral Sclerosis>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesNeurology

Cancer Study: LY3537982 for KRAS G12C Mutant Tumors

We are testing a new drug, LY3537982, in patients with advanced solid tumors that have a specific genetic mutation. The goal is to see how well it works and how safe it is when used alone or with other cancer treatments.

KRAS G12C-Mutant Advanced Solid TumorsSafety phase (I)Efficacy phase (II)≤5 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesOncology

Actinic Keratosis: Sinecatechins Ointment Study

We are studying a green tea extract ointment for adults with actinic keratosis on the scalp and face. The goal is to see if it clears skin lesions better than a placebo and to assess its safety.

Actinic Keratosis3-6 monthsConfirmation phase (III)≤5 visitsInvestigational MedicinesDermatology

Melanoma Treatment: Fianlimab and Cemiplimab Study

We are investigating whether combining fianlimab and cemiplimab is safer and more effective than cemiplimab alone for adults with resectable stage III or IV melanoma. This study aims to see how well these treatments work before surgery.

Malignant Melanoma>2 yearsEfficacy phase (II)≤5 visitsStandard MedicinesCost ReimbursementPartially RemoteDermatologyOncology

Kidney Stones: Furosemide Injection Study

We are investigating whether a Furosemide injection after kidney stone removal improves the chances of being stone-free and reduces the risk of infections. This study involves patients undergoing flexible ureteroscopy for kidney stones.

Kidney Stones>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementUrology

Eptinezumab for Migraines in Children and Adolescents

We are studying the long-term safety of eptinezumab in children and teens aged 6 to 17 who experience chronic or episodic migraines. This research aims to ensure the medication is safe for young patients.

Migraine6-12 monthsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteNeurologyPediatrics

Severe Infections: MODIFY Trial

We are testing a new method to guide antibiotic treatment for severe infections, aiming to reduce unnecessary antibiotic use. This study will also evaluate how this approach impacts recovery and health outcomes.

Sepsis>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteInfectious DiseasesInternal Medicine

Vericiguat for Vasospastic Angina

We are studying how vericiguat affects heart function and angina episodes in patients with vasospastic angina. The trial also looks at quality of life and safety of the treatment.

Vasospastic Angina1-2 yearsEfficacy phase (II)≤5 visitsPost-Trial Drug AccessStandard MedicinesPartially RemoteCardiologyInternal Medicine

Flu Vaccine Study for Adults 65 and Older

We are testing a new adjuvanted flu vaccine to see if it works as well as a standard flu vaccine in preventing influenza in older adults. The study will also evaluate safety and immune response to the vaccine.

Influenza6-12 monthsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesInfectious Diseases

TAK-330 for Reversing Blood Thinner Effects in Urgent Surgery

We are studying whether TAK-330 can effectively reverse the effects of certain blood thinners in patients needing urgent surgery. This trial compares TAK-330 to the standard treatment to see which works better.

Patients on Factor Xa Inhibitors Needing Urgent Intervention≤3 monthsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteHematologyInternal Medicine

Fremanezumab for Pain in Complex Regional Pain Syndrome

We are studying whether fremanezumab can reduce pain in patients with Complex Regional Pain Syndrome compared to a placebo. The trial also examines how this treatment affects disease symptoms and function.

Complex Regional Pain Syndrome≤3 monthsEfficacy phase (II)≤5 visitsStandard MedicinesCost ReimbursementNeurology

Menière's Disease: Methylprednisolone Injection Study

We are investigating whether an injection of methylprednisolone can reduce vertigo attacks in patients with Menière's disease. This study will also assess its effects on hearing and overall quality of life.

Menière's Disease1-2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteOtolaryngology

Lung Cancer Treatment: MK-2870 with Pembrolizumab

We are comparing a new combination treatment for metastatic non-small cell lung cancer to standard therapy. This study aims to see if the combination improves survival and quality of life for patients with high PD-L1 levels.

Metastatic Non-Small Cell Lung Cancer>2 yearsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessInvestigational MedicinesOncology

Ovarian Cancer Diagnosis: IMPROCAS Study

We are exploring new blood test methods and imaging techniques to improve how ovarian cancer is diagnosed. This study aims to create a better model for identifying the disease and understanding its severity.

Ovarian CancerEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesGynecology and ObstetricsInternal MedicineOncology

Hereditary Angioedema: OCTA-C1-INH Treatment Study

We are studying a new intravenous treatment for people with hereditary angioedema to see if it effectively relieves symptoms during acute attacks. The trial includes adolescents and adults, and also looks at safety and quality of life.

Hereditary Angioedema1-2 yearsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteAllergologyHematology

Melatonin for Chronic Back Pain

We are studying whether melatonin can help reduce pain and improve sleep in people with chronic back pain. This trial compares melatonin to a placebo to see which is more effective.

Chronic Back Pain≤3 monthsConfirmation phase (III)≤5 visitsStandard MedicinesCost ReimbursementInternal MedicineOrthopedics and Traumatology

Cardiogenic Shock: Early Empagliflozin Treatment

We are studying if starting empagliflozin early helps patients with cardiogenic shock improve their heart function and reduce hospital visits. This trial compares the new treatment with standard care to see which is more effective.

Cardiogenic Shock3-6 monthsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteCardiologyInternal Medicine

Gastroesophageal and Pancreatic Cancer: New Imaging Technique

We are testing a new PET/CT imaging method to see if it improves cancer diagnosis and staging for patients with gastroesophageal and pancreatic cancer. This study aims to enhance comfort and effectiveness compared to standard imaging.

Pancreatic and Gastroesophageal CancerEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesOncologyOtolaryngology

Breast Cancer-Related Lymphedema: Topical Tacrolimus Study

We are investigating whether a topical ointment can reduce swelling in patients with breast cancer-related lymphedema. This study compares the ointment to a placebo to see if it improves symptoms and quality of life.

Lymphedema1-2 yearsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessStandard MedicinesPartially RemoteInternal MedicineOncology

Periodontitis: Vitamin D3 Supplementation Study

We are testing whether vitamin D3 can improve gum health in people with periodontitis and low vitamin D levels. This study will help us understand its effects alongside standard gum treatments.

Periodontitis6-12 monthsMonitoring phase (IV)≤5 visitsStandard MedicinesInternal MedicineOtolaryngology