Search Clinical Trials in the European Union

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221-240 of 3,900 trials

Ovarian Cancer: Niraparib and Abemaciclib Combination

We are studying the effects of combining niraparib and abemaciclib for patients with late-stage ovarian cancer. This trial aims to see if this treatment can improve outcomes for those who have already received other therapies.

Ovarian Cancer>2 yearsSafety phase (I)Efficacy phase (II)Gynecology and ObstetricsOncology

Inclusion Body Myositis: ABC008 Treatment Study

We are studying the safety and effectiveness of a new treatment called ABC008 for people with Inclusion Body Myositis. The goal is to see if it improves muscle function and strength compared to a placebo.

Inclusion Body Myositis1-2 yearsEfficacy phase (II)Confirmation phase (III)>20 visitsPost-Trial Drug AccessStandard MedicinesPartially RemoteNeurologyRheumatology

Abdominal Aortic Aneurysm: Stem Cell Treatment Study

We are testing whether injecting stem cells into the aneurysm sac is safe and effective for patients undergoing endovascular repair. This study compares outcomes with those from traditional treatment methods.

Abdominal Aortic Aneurysm1-2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesCardiologyInternal MedicineOrthopedics and Traumatology

Multiple Myeloma: Belantamab Treatment Study

We are investigating the safety and effectiveness of belantamab for treating multiple myeloma, both on its own and with other therapies. This study aims to find out how well it works for patients.

Multiple Myeloma>2 yearsSafety phase (I)Efficacy phase (II)HematologyOncology

Gastrectomy: Pancreatic Enzyme Supplementation

We are investigating if taking pancreatic enzymes with meals improves quality of life for patients after gastrectomy. This study aims to see how these enzymes may help in recovery.

Patients after Gastrectomy>2 yearsConfirmation phase (III)Investigational MedicinesGastroenterologyInternal Medicine

Generalized Periodontitis: Valaciclovir Treatment Study

We are investigating whether the antiviral drug Valaciclovir can improve treatment outcomes for people with advanced generalized periodontitis. This study compares its effects to standard treatments and a placebo.

Generalized Periodontitis≤3 monthsConfirmation phase (III)Investigational MedicinesInfectious DiseasesOtolaryngology

Roxadustat for Anemia in Children with Chronic Kidney Disease

We are studying a new treatment for anemia in children and adolescents with chronic kidney disease. The trial will evaluate its effectiveness, safety, and how it impacts daily life.

Nephrogenic Anemia1-2 yearsConfirmation phase (III)11-15 visitsNo PlaceboStandard MedicinesCost ReimbursementHematologyNephrology

Acute Myeloid Leukemia: Hydroxyurea and Valproic Acid Study

We are investigating a new treatment combination for patients with acute myeloid leukemia or high-risk myelodysplastic syndrome who cannot receive standard chemotherapy. The study will assess safety, effectiveness, and quality of life.

Acute Myeloid Leukemia6-12 monthsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Advanced Dedifferentiated Liposarcoma: Pemigatinib and Retifanlimab Study

We are studying the effects of two medications on patients with advanced dedifferentiated liposarcoma. The goal is to see if they improve treatment outcomes and quality of life.

Dedifferentiated Liposarcoma3-6 monthsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Isolated MMA: Long-Term Study of mRNA-3705

We are evaluating the long-term safety and effects of mRNA-3705 in individuals with Isolated MMA who have participated in earlier studies. This research aims to understand how the treatment impacts health and daily activities over time.

Methylmalonic AciduriaSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteInternal Medicine

Oxygen Therapy for AECOPD: Standard vs Targeted Approach

We are investigating whether a targeted oxygen therapy can reduce mortality and improve breathing in patients with acute exacerbations of chronic obstructive pulmonary disease. This study compares it to standard oxygen treatment to see which is more effective.

COPD Exacerbation>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicinePulmonology

Kidney Transplant: Comparing rATG and Basiliximab

We are studying whether rATG is more effective than basiliximab in preventing kidney transplant rejection in sensitized patients without pre-existing antibodies. This trial aims to improve outcomes for kidney transplant recipients.

Kidney Transplant>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesNephrology

Osteoarthritis: Walking Rehabilitation with Anti-Inflammatory Treatment

We are exploring how a specific anti-inflammatory medication can support a walking rehabilitation program for people with hip or knee osteoarthritis. The goal is to see if this combination improves walking ability and overall comfort.

Osteoarthritis of the Hip or Knee≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineRheumatology

Acute Myeloid Leukemia: Comparing Treatment Regimens

We are studying two different conditioning regimens for adults with acute myeloid leukemia before stem cell transplantation. The goal is to see which regimen may improve survival and recovery outcomes.

Acute Myeloid Leukemia in Remission>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesHematology

Rheumatoid Arthritis: Precision Therapy Using Biomarkers

We are studying if tissue samples can help identify which RA patients will respond best to new biologic treatments. This may improve treatment outcomes for those who haven't benefited from standard therapies.

Rheumatoid ArthritisMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesRheumatology

Hemophilia A: Dendritic Cell Therapy

We are testing a new treatment using patients' own dendritic cells to help manage severe bleeding in hemophilia A. This study aims to see if it can improve the body's tolerance to a crucial clotting factor.

Hemophilia A with Anti Factor VIII>2 yearsSafety phase (I)Hematology

Crohn's Disease: Risankizumab for Children

We are studying the safety and effectiveness of risankizumab in children aged 2 to under 18 with moderately to severely active Crohn's disease. This trial aims to help those who haven't responded to other treatments.

Crohn's Disease>2 yearsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesPartially RemoteGastroenterologyInternal Medicine

H3 K27M-Mutant Diffuse Glioma: ONC201 Treatment Study

We are studying the effects of ONC201 in patients with H3 K27M-mutant diffuse glioma after radiotherapy. The goal is to see if it improves outcomes compared to a placebo.

H3 K27M-Mutant Diffuse GliomaConfirmation phase (III)Investigational MedicinesCost ReimbursementPartially RemoteOncology

Nuwiq for Managing Bleeding in Hemophilia A Patients During Surgery

We are studying how well Nuwiq works alongside emicizumab for patients with severe hemophilia A undergoing major surgery. The goal is to see if it helps control bleeding effectively and safely.

Haemophilia AMonitoring phase (IV)No PlaceboStandard MedicinesHematology

Nuwiq for Women and Girls with Hemophilia A Needing Surgery

We are studying how well Nuwiq works to control bleeding during major surgery for women and girls with hemophilia A. The trial will also look at its safety and effects on blood product use.

Haemophilia A≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesHematologyInternal Medicine