Search Clinical Trials in the European Union

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Confirmation phase (III)
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281-300 of 1,307 trials

Chemotherapy-Induced Peripheral Neuropathy: Capsaicin Patch vs. Duloxetine

We are studying whether a capsaicin patch can reduce nerve pain better than duloxetine in patients with chemotherapy-induced peripheral neuropathy. The trial also looks at safety and overall quality of life improvements.

Chemotherapy Induced Peripheral Neuropathy>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesNeurologyOncology

Chronic Coccygodynia: Capsaicin 8% Patches

We are testing the effectiveness of capsaicin patches for people suffering from chronic tailbone pain. This study aims to see if these patches can provide better pain relief than a placebo.

Neuropathic PainChronic Coccygodynia>2 yearsConfirmation phase (III)Neurology

Choroidal Melanoma: Belzupacap Sarotalocan Treatment

We are studying a new treatment for people with primary indeterminate lesions or small choroidal melanoma. The goal is to see if it is more effective and safe compared to a placebo.

Choroidal Melanoma>2 yearsConfirmation phase (III)>20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementOncologyOphthalmology

Hydroxychloroquine for Pregnancy Outcomes in Women with Antiphospholipid Antibodies

We are studying whether hydroxychloroquine can improve pregnancy outcomes for women with antiphospholipid antibodies. This research aims to help understand its potential benefits during pregnancy.

Antiphospholipid Antibodies>2 yearsConfirmation phase (III)6-10 visitsStandard MedicinesGynecology and ObstetricsInternal Medicine

Vitamin D Deficiency: Cholecalciferol Study for Postmenopausal Women

We are investigating the right dose of Cholecalciferol to help postmenopausal women with vitamin D deficiency. The study also looks at how satisfied participants are with this vitamin D supplement.

Postmenopausal Women6-12 monthsConfirmation phase (III)No PlaceboStandard MedicinesEndocrinologyGynecology and Obstetrics

Post-Stroke Pain: Understanding Nerve Roles

We are investigating how peripheral nerves influence pain in individuals who have had a stroke. This research may help develop better pain management strategies for stroke survivors.

Central Neuropathic Pain After Stroke>2 yearsConfirmation phase (III)Neurology

Cytisine for Quitting Nicotine in E-Cigarettes and Tobacco

We are studying whether cytisine, combined with behavioral support, helps people quit using nicotine in e-cigarettes or tobacco cigarettes better than a placebo. This trial is for individuals motivated to stop using these products.

Quitting Electronic Cigarettes≤3 monthsConfirmation phase (III)Standard MedicinesPsychiatry

Atopic Dermatitis in Children: Upadacitinib vs. Dupilumab

We are studying whether upadacitinib is as safe and effective as dupilumab for children aged 2 to under 12 with moderate to severe atopic dermatitis. This trial aims to find better treatment options for young patients.

Atopic Dermatitis>2 yearsConfirmation phase (III)>20 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteAllergologyDermatologyPediatrics

Myelofibrosis: Navtemadlin with Ruxolitinib

We are studying whether adding navtemadlin to ruxolitinib helps patients with myelofibrosis who aren't responding well to their current treatment. The trial looks at changes in spleen size and symptoms, along with safety and survival.

MyelofibrosisPrimary MyelofibrosisSecondary Myelofibrosis>2 yearsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesCost ReimbursementHematologyOncology

Insomnia in Psychiatric Patients: Melatonin vs. Quetiapine

We are studying whether melatonin or low-dose quetiapine can improve sleep and overall well-being in patients with psychiatric disorders and chronic insomnia. This trial compares these treatments to a placebo to find the most effective option.

Psychiatric Disorders and Insomnia>2 yearsEfficacy phase (II)Confirmation phase (III)Standard MedicinesPsychiatry

Guselkumab for Pediatric Crohn’s Disease

We are studying the safety and effectiveness of guselkumab in children with moderately to severely active Crohn’s disease. This trial aims to see how well the treatment works after initial positive responses.

Crohn's Disease1-2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteGastroenterologyPediatrics

New Surgical Treatment for Wet AMD: Vitrectomy and TPA

We are studying a new surgical approach for people with submacular hemorrhage caused by wet AMD. This trial compares it to the standard treatment to see if it improves vision and eye health.

Exudative Age-Related Macular Degeneration1-2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOphthalmology

Recurrent Pericarditis in Children: Anakinra vs. Steroids

We are studying whether Anakinra is more effective than steroids for controlling recurrent pericarditis in children who haven't responded to other treatments. This trial aims to help improve care for young patients facing this condition.

Pericarditis3-6 monthsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesCardiologyRheumatology

Chronic Open-Angle Glaucoma: Preservative-Free Bimatoprost Eye Drops

We are comparing a new preservative-free eye drop to a standard treatment for patients with chronic open-angle glaucoma or ocular hypertension. The goal is to see if the new formulation is effective and safe for managing eye pressure.

Chronic Open-angle GlaucomaOcular Hypertension3-6 monthsConfirmation phase (III)No PlaceboStandard MedicinesOphthalmology

Chronic Pouchitis in Children: Vedolizumab IV Study

We are testing the intravenous medication vedolizumab in children with active chronic pouchitis to see if it helps them achieve remission. The study will also look at how well the treatment is tolerated and its overall effectiveness.

Pouchitis1-2 yearsConfirmation phase (III)16-20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementGastroenterologyPediatrics

Chronic Migraine: Dysport Treatment Study

We are studying whether Dysport can help reduce the number of migraine days in adults with chronic migraines. The trial will also look at its safety and overall effectiveness compared to a placebo.

Chronic Migraine1-2 yearsConfirmation phase (III)11-15 visitsStandard MedicinesPartially RemoteNeurology

Colorectal Cancer: Post-Surgery Chemotherapy Study

We are investigating whether restarting chemotherapy after surgery helps patients with colorectal cancer that has spread to the liver live longer and stay cancer-free. This study compares different treatment approaches to find the best option.

Metastatic Colorectal Cancer>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesGastroenterologyOncology

Sickle Cell Pain Relief: Intranasal Sufentanil Study

We are investigating whether a new nasal spray for pain relief helps children with severe sickle cell pain crises feel better faster than standard treatments. This study aims to improve pain management in pediatric emergency care.

Vaso-Occlusive Crisis>2 yearsConfirmation phase (III)Investigational MedicinesHematologyInternal MedicinePediatrics

Cutaneous Lupus Erythematosus: Litifilimab Injections

We are studying the long-term safety and effects of Litifilimab injections for adults with active cutaneous lupus erythematosus who have not responded to other treatments. This research aims to see if it can improve symptoms and overall quality of life.

Skin Lupus (Cutaneous Lupus Erythematosus)>2 yearsConfirmation phase (III)>20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementDermatologyRheumatology

Bomedemstat vs Best Available Therapy for Essential Thrombocythemia

We are studying a new treatment for patients with essential thrombocythemia who haven't responded to hydroxyurea. The trial aims to see if bomedemstat is safer and more effective than current therapies.

Essential Thrombocythemia>2 yearsConfirmation phase (III)>20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementHematology