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461-480 of 3,900 trials

Chronic Myeloid Leukemia: ELVN-001 Treatment

We are investigating a new drug, ELVN-001, for patients with chronic myeloid leukemia. The goal is to see if it is safe and effective in treating this type of cancer.

Chronic Myeloid Leukemia>2 yearsSafety phase (I)HematologyOncology

Menière's Disease: Methylprednisolone Injection Study

We are investigating whether an injection of methylprednisolone can reduce vertigo attacks in patients with Menière's disease. This study will also assess its effects on hearing and overall quality of life.

Menière's Disease1-2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteOtolaryngology

Delayed Gastric Emptying: Nicotine Patch Study

We are investigating whether a nicotine patch can help patients who have had pancreatoduodenectomy by reducing delayed gastric emptying. The study also looks at the safety and tolerability of this treatment compared to a placebo.

Pancreatoduodenectomy≤3 monthsEfficacy phase (II)Investigational MedicinesGastroenterologyInternal Medicine

Lung Cancer Treatment: MK-2870 with Pembrolizumab

We are comparing a new combination treatment for metastatic non-small cell lung cancer to standard therapy. This study aims to see if the combination improves survival and quality of life for patients with high PD-L1 levels.

Metastatic Non-Small Cell Lung Cancer>2 yearsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessInvestigational MedicinesOncology

Ovarian Cancer Diagnosis: IMPROCAS Study

We are exploring new blood test methods and imaging techniques to improve how ovarian cancer is diagnosed. This study aims to create a better model for identifying the disease and understanding its severity.

Ovarian CancerEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesGynecology and ObstetricsInternal MedicineOncology

Teicoplanin Dosing: Optimized vs. Standard Care

We are studying whether a new dosing method for teicoplanin helps patients achieve better treatment results compared to standard dosing. This trial looks at how quickly patients reach the right drug levels and their overall recovery.

Sepsis1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

Liver Problems: Study of Vimseltinib

We are investigating how the drug vimseltinib is processed in people with liver problems. This study aims to understand its absorption and effects in this group.

Tenosynovial Giant Cell Tumor (TGCT)Malignant Solid Tumors (MST)1-2 yearsSafety phase (I)HepatologyOncology

Type 2 Diabetes: BCAA Oxidation Study

We are investigating whether boosting branched-chain amino acid oxidation can lower blood sugar levels in people with type 2 diabetes. The study also examines effects on insulin sensitivity, heart health, and cognitive function.

Type 2 Diabetes6-12 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementDiabetologyEndocrinology

Cancer Treatment: Evaluating CC-486 in Liver Impairment

We are studying how CC-486 works in people with moderate or severe liver issues compared to those with normal liver function. This research aims to ensure safe and effective treatment options for cancer patients.

Myeloid MalignanciesSafety phase (I)HematologyHepatology

Light Chain Amyloidosis: Etentamig Treatment Study

We are evaluating the safety and effectiveness of Etentamig for individuals with Light Chain Amyloidosis. This study aims to understand how well this treatment works for managing the disease.

Light Chain Amyloidosis>2 yearsSafety phase (I)HematologyOncology

E. coli Urinary Tract Infection: Pivmecillinam Treatment

We are studying whether an oral medication called pivmecillinam is as effective as standard treatments for E. coli urinary tract infections. This trial will also assess safety and other health effects.

Febrile Urinary Tract Infection>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesInfectious DiseasesUrology

Follicular Lymphoma: Tisagenlecleucel vs. Standard Care

We are studying a new treatment called tisagenlecleucel for adults with relapsed or refractory follicular lymphoma. The goal is to see if it helps patients live longer and respond better than current standard treatments.

Follicular Lymphoma>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteHematologyOncology

Chronic Lung Allograft Dysfunction: Belumosudil Tablets

We are testing belumosudil tablets to see if they improve lung function in adults with chronic lung allograft dysfunction after lung transplantation. The study will also look at how this treatment affects exercise capacity and overall health.

Lung Transplant Rejection6-12 monthsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteInternal MedicinePulmonology

Cholestatic Pruritus: Linerixibat Treatment Study

We are studying the long-term safety and tolerability of linerixibat for people with cholestatic pruritus due to primary biliary cholangitis. The trial also looks at how this treatment affects quality of life and itch relief.

Cholestatic PruritusPrimary Biliary Cholangitis1-2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementGastroenterologyHepatology

Panguian Clinical Trial

We are exploring a new treatment in this clinical trial. Participants will help us understand its effects and potential benefits.

Rheumatoid Arthritis>2 yearsConfirmation phase (III)Monitoring phase (IV)Orthopedics and Traumatology

Polycystic Ovary Syndrome: Letrozole vs. Gonadotropins for Insemination

We are studying whether letrozole can be a better option than gonadotropins for achieving pregnancy in women with polycystic ovary syndrome. The trial will also examine miscarriage rates and treatment responses.

Insemination in Patients with Polycystic Ovary Syndrome>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesEndocrinologyGynecology and Obstetrics

HER2-Positive Metastatic Cancer: Trastuzumab Emtansine Study

We are providing ongoing treatment with trastuzumab emtansine for patients who previously benefited from this therapy. The study aims to assess the safety of long-term use, either alone or with other cancer treatments.

Metastatic Breast CancerEfficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesOncology

Non-Squamous Lung Cancer: Pembrolizumab Dosing Study

We are comparing the usual dose of Pembrolizumab with a lower dose for patients with non-squamous lung cancer. The goal is to see if the lower dose is as effective in maintaining treatment benefits.

Metastatic Non-Squamous Lung Cancer>2 yearsConfirmation phase (III)OncologyPulmonology

Knee Cartilage Defects: Stem Cell Treatment Study

We are testing whether a combination of stem cells and a 3D scaffold improves healing in knee cartilage defects compared to standard treatment. This study also looks at the safety of using these stem cells.

Knee Cartilage Defect>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementOrthopedics and TraumatologyRheumatology

Fish Oil for Recovery in High-Risk Heart Surgery Patients

We are studying whether an intravenous fish oil treatment can prevent atrial fibrillation and improve recovery in patients undergoing high-risk cardiac surgery. This trial compares the fish oil treatment to a placebo.

Critical Illness3-6 monthsEfficacy phase (II)Investigational MedicinesCardiologyInternal Medicine