Search Clinical Trials in the European Union

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Confirmation phase (III)
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61-80 of 1,307 trials

Skin Candidiasis: Mecloderm® Ointment Study

We are comparing a new ointment with clotrimazole and betamethasone to an existing treatment and a placebo for patients with moderate to severe skin infections caused by yeast. The study aims to assess how well these treatments work and their safety.

Skin and Nail Candidiasis≤3 monthsConfirmation phase (III)≤5 visitsStandard MedicinesDermatologyInfectious Diseases

Heart Attack Recovery: Milvexian Study

We are testing a new oral medication, milvexian, to see if it helps reduce the risk of further heart problems in patients after a heart attack. This study compares milvexian to a placebo alongside standard treatment.

Acute Coronary Syndrome>2 yearsConfirmation phase (III)Investigational MedicinesCost ReimbursementPartially RemoteCardiologyInternal Medicine

Dexamethasone for Moderate to Severe Depression

We are studying whether adding dexamethasone to standard depression treatment can improve symptoms for those with moderate to severe depression. This trial aims to assess its safety and effectiveness.

Depression6-12 monthsConfirmation phase (III)≤5 visitsInvestigational MedicinesCost ReimbursementPartially RemotePsychiatry

Breast Cancer: Elacestrant vs. Standard Therapy

We are studying whether elacestrant can help women with ER+/HER2- breast cancer who have signs of relapse delay cancer spread compared to standard treatments. The trial also looks at safety and how patients feel about the treatment.

Breast Cancer>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncology

ALK-Positive Anaplastic Large Cell Lymphoma: Vinblastine Treatment

We are studying whether Vinblastine can effectively treat children and adolescents with standard risk ALK-positive anaplastic large cell lymphoma. The goal is to see if it can cure at least 75% of these patients.

ALK-positive Anaplastic Large Cell Lymphoma>2 yearsConfirmation phase (III)>20 visitsNo PlaceboStandard MedicinesOncologyPediatrics

Atypical Teratoid/Rhabdoid Tumors: High-Dose Chemotherapy vs. Radiotherapy

We are studying whether high-dose chemotherapy is as effective as radiotherapy for young children with ATRT. This trial aims to improve treatment options and understand the long-term effects on health and quality of life.

Atypical Teratoid/Rhabdoid Tumors (ATRT)>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesOncologyPediatrics

Atopic Dermatitis: Lebrikizumab for Kids

We are studying a new treatment for children and teens with moderate-to-severe atopic dermatitis. The goal is to see if it works better than a placebo when used alongside standard treatments.

Atopic Dermatitis (Eczema)3-6 monthsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesDermatology

Advanced Non-Small Cell Lung Cancer: Fianlimab and Cemiplimab Study

We are studying whether a combination of Fianlimab and Cemiplimab is more effective than Cemiplimab alone for adults with advanced non-small cell lung cancer. This trial focuses on patients whose tumors express PD-L1 at high levels.

Advanced Non-Small Cell Lung Cancer>2 yearsEfficacy phase (II)Confirmation phase (III)Standard MedicinesPartially RemoteOncology

Hypertension in Chronic Kidney Disease: Diuretic Treatment Study

We are investigating if a new diuretic-based treatment helps people with moderate to severe chronic kidney disease and uncontrolled hypertension. The goal is to see if it can reduce serious health issues like kidney failure and heart problems.

Chronic Kidney DiseaseUncontrolled Hypertension>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesCardiologyNephrology

Multiple Myeloma: Iberdomide vs. Lenalidomide Maintenance Therapy

We are comparing two treatments for newly diagnosed multiple myeloma patients after stem cell transplant to see which one may help keep the disease from worsening. This study will also look at safety and quality of life for participants.

Newly Diagnosed Multiple Myeloma>2 yearsConfirmation phase (III)>20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementHematologyOncology

Osimertinib (TAGRISSO) Continuation Study

We are providing ongoing treatment with osimertinib for patients who have benefited from it in a previous study. The goal is to monitor safety and tolerability as they continue their treatment.

Non-small Cell Lung Cancer>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteOncology

Corticosteroid Treatment for Acute Myocarditis

We are studying whether intravenous corticosteroids can improve heart function in patients with acute myocarditis and mildly reduced heart performance. This trial compares corticosteroid therapy to standard treatment options.

Acute Myocarditis>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesCardiologyInternal Medicine

Dupuytren Contracture: Needle Procedure with Corticosteroid Injection

We are comparing a needle procedure with a corticosteroid injection to one with a saline injection for Dupuytren Contracture in the hand. This study aims to see if the corticosteroid helps reduce the chance of the condition returning.

Dupuytren's Contracture>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesDermatologyOrthopedics and Traumatology

High-Risk Prostate Cancer: THUNDER Trial

We are studying new diagnostic tracers and treatment options for men with high-risk prostate cancer. The goal is to see if these methods improve survival and quality of life compared to standard treatments.

Prostate Cancer1-2 yearsEfficacy phase (II)Confirmation phase (III)6-10 visitsInvestigational MedicinesOncologyUrology

Atopic Dermatitis: Rocatinlimab Study

We are investigating the long-term safety and effectiveness of rocatinlimab for adults and adolescents with moderate-to-severe atopic dermatitis. The study compares the treatment's effects to a placebo in those who have previously responded to the medication.

Atopic DermatitisConfirmation phase (III)Investigational MedicinesCost ReimbursementAllergologyDermatology

Stroke Prevention in Kidney Disease: Apixaban Study

We are studying whether apixaban can safely reduce the risk of strokes in patients with chronic kidney disease stage 5 and atrial fibrillation. This trial will help us understand its effects compared to standard care.

Atrial Fibrillation with Chronic Kidney Disease Stage 5>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesCardiologyInternal MedicineNephrology

Ovarian Cancer: Mirvetuximab Soravtansine with Bevacizumab

We are studying a new treatment combining mirvetuximab soravtansine and bevacizumab for adults with recurrent ovarian cancer who have not progressed after chemotherapy. The goal is to see if this combination helps patients live longer without their cancer worsening.

Ovarian and Fallopian Tube Cancer>2 yearsConfirmation phase (III)Monitoring phase (IV)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementGynecology and ObstetricsOncology

Kidney Transplant: Belatacept vs. Calcineurin Inhibitors

We are studying whether switching to a new immunosuppressive medication helps adolescent kidney transplant recipients maintain their health better than staying on their current treatment. This trial focuses on patients aged 12 to under 18 years.

Kidney Transplant>2 yearsConfirmation phase (III)>20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteInternal MedicineNephrology

Low-Grade Gliomas: 18F-FDOPA PET Imaging Study

We are exploring whether a new imaging technique can better identify aggressive features in suspected low-grade gliomas without MRI contrast enhancement. This may help improve diagnosis and treatment planning for patients.

Low Grade GliomaConfirmation phase (III)No PlaceboInvestigational MedicinesNeurologyOncology

Major Depressive Disorder: Minocycline vs. Celecoxib

We are studying whether minocycline or celecoxib can help patients with Major Depressive Disorder who haven't responded to previous treatments. The trial will compare how well these medications work and how patients respond to them.

Major Depressive Disorder≤3 monthsConfirmation phase (III)6-10 visitsStandard MedicinesCost ReimbursementPsychiatry