Search Clinical Trials in the European Union

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941-960 of 3,900 trials

Heart Failure: Trimetazidine Study

We are investigating how trimetazidine affects heart function and health markers in people with heart failure. The goal is to see if it can improve symptoms and reduce hospital visits.

Heart Failure with Preserved Ejection Fraction1-2 yearsMonitoring phase (IV)Standard MedicinesCardiologyInternal Medicine

Myelofibrosis: INCB057643 Safety Study

We are testing a new drug, INCB057643, for people with myelofibrosis and other advanced blood cancers. The study focuses on understanding its safety and how well patients tolerate it.

MyelofibrosisMyeloproliferative NeoplasmMyelodysplastic Syndrome>2 yearsSafety phase (I)Hematology

Breast Reconstruction: Goal-Directed Fluid Therapy

We are studying how a specific fluid management approach during DIEP breast reconstruction may reduce swelling and improve healing. This trial aims to see if it helps with better blood flow to the surgical area.

Low Blood Pressure>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGynecology and ObstetricsInternal MedicineOtolaryngology

Efgartigimod PH20 SC for Children with Generalized Myasthenia Gravis

We are studying a new treatment for children aged 2 to under 18 with generalized myasthenia gravis. The trial will help us understand the right dose and evaluate its safety and effects on daily life.

Myasthenia Gravis3-6 monthsEfficacy phase (II)Confirmation phase (III)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteInternal MedicineNeurology

Atopic Dermatitis: Personalized Treatment Approaches

We are studying how genetic and biochemical markers can help choose the best treatment for patients with atopic dermatitis needing stronger therapies. This research may lead to better management strategies tailored to individual needs.

Atopic Dermatitis6-12 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesAllergologyDermatology

VAXXAIR TRIAL: Comparing Nasal and Injectable Flu Vaccines

We are studying how well a nasal flu vaccine works compared to an injectable one in building immunity. This research aims to find out which method produces a stronger immune response in the body.

Influenza>2 yearsMonitoring phase (IV)6-10 visitsInvestigational MedicinesCost ReimbursementInfectious DiseasesPulmonology

GHB Use Disorder: Baclofen Treatment Study

We are testing whether adding baclofen can help reduce the need for GHB during detox for patients with GHB use disorder. This study aims to improve the detox process for those seeking recovery.

GHB Use DisorderEfficacy phase (II)No PlaceboStandard MedicinesPsychiatry

Neonatal OTC Deficiency: ECUR-506 Treatment Study

We are investigating a new treatment called ECUR-506 for boys under 9 months with neonatal onset OTC deficiency. The study will help us understand its safety and how well it works.

Ornithine Transcarbamylase Deficiency6-12 monthsSafety phase (I)Efficacy phase (II)>20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteInternal MedicinePediatrics

Chronic Spontaneous Urticaria: Omalizumab Treatment Intervals

We are studying whether adults with well-controlled chronic spontaneous urticaria can safely extend the time between omalizumab treatments while maintaining symptom control.

Chronic Spontaneous Urticaria6-12 monthsConfirmation phase (III)Monitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteAllergologyDermatology

Fluorescence Imaging in Crohn’s Disease and Psoriasis

We are exploring a new imaging technique to help diagnose and monitor Crohn’s disease and psoriasis. This study aims to see if it provides clearer insights into these conditions.

Crohn's DiseasePsoriasis1-2 yearsSafety phase (I)AllergologyDermatologyGastroenterology

Colorectal Liver Metastases: HAIP-SYST Treatment Study

We are investigating a new combination of local and systemic chemotherapy for patients with initially unresectable colorectal liver metastases. The study aims to see if this approach improves survival and quality of life compared to standard treatment.

Colorectal Liver Metastases1-2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesHepatologyOncology

Advanced Solid Tumors: VVD130037 Treatment

We are testing a new drug for patients with advanced solid tumors to see how safe it is and how well it may work against cancer. This study will help us understand its effects on the body and its potential benefits.

Solid TumorSquamous Non-Small Cell Lung Cancer>2 yearsSafety phase (I)Oncology

Carbetocin Nasal Spray for Hunger in Prader-Willi Syndrome

We are studying the safety of carbetocin nasal spray for people with Prader-Willi Syndrome who experience uncontrollable hunger. The trial also looks at how this treatment may help with anxiety and caregiver challenges.

Hyperphagia>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesEndocrinologyPediatrics

Methylphenidate for Children with KBG Syndrome

We are studying how well methylphenidate helps children and adolescents with KBG syndrome manage attention and emotional symptoms. This trial also looks at family functioning and any side effects compared to typical ADHD treatments.

KBG Syndrome3-6 monthsMonitoring phase (IV)6-10 visitsInvestigational MedicinesCost ReimbursementPartially RemotePediatricsPsychiatry

Diffuse Large B-cell Lymphoma: Rituximab and Golcadomide Study

We are testing a new combination treatment for older frail patients with Diffuse Large B-cell non-Hodgkin Lymphoma. This study aims to see if it can improve outcomes without traditional chemotherapy.

Diffuse Large B-cell Lymphoma>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesHematologyInternal Medicine

Heart Failure: Colchicine Study

We are investigating whether colchicine can improve health status in people with heart failure compared to a placebo. This study aims to see if it helps patients feel better based on specific health questionnaires.

Heart Failure with Preserved Ejection Fraction>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesCardiologyInternal Medicine

Menopausal Women with Breast Cancer: Prasterone Therapy

We are studying whether a vaginal treatment can improve urinary and vaginal symptoms in menopausal women with a history of breast cancer or those currently on hormone therapy. The goal is to see how this therapy affects their quality of life and overall wellbeing.

Breast CancerGenitourinary Syndrome of Menopause≤3 monthsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesGynecology and ObstetricsOncologyUrology

Nicotinamide for OPA1 Dominant Optic Atrophy

We are studying whether nicotinamide (vitamin B3) is safe and effective for people with OPA1 Dominant Optic Atrophy. The trial will assess its impact on vision and overall quality of life.

Dominant Optic Atrophy>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesCost ReimbursementNeurologyOphthalmology

Cell Therapy for Amyotrophic Lateral Sclerosis

We are investigating whether a new cell therapy can help patients with ALS. This study aims to explore its effects on disease progression and quality of life.

Amyotrophic Lateral Sclerosis>2 yearsEfficacy phase (II)Neurology

Cytomegalovirus Treatment: Letermovir and Valganciclovir Combination

We are studying whether a combination of letermovir and valganciclovir helps kidney transplant recipients with CMV infections achieve better viral response than valganciclovir alone.

Cytomegalovirus InfectionKidney Transplant>2 yearsConfirmation phase (III)11-15 visitsInvestigational MedicinesInfectious DiseasesNephrology