Search Clinical Trials in the European Union

Duration
Visits
Confirmation phase (III)
Intake methods
Benefits
Drugs
Locations
Clinical Specialty
961-980 of 1,307 trials

Thyroid Eye Disease: VRDN-003 Treatment Study

We are investigating whether VRDN-003 can improve symptoms in individuals with active thyroid eye disease. The study will also check if the treatment is safe and well-tolerated compared to a placebo.

Thyroid Eye Disease1-2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteEndocrinologyOphthalmology

Seizures in Developmental and Epileptic Encephalopathy: Bexicaserin (LP352)

We are studying the safety and effectiveness of a new medication, bexicaserin, for treating seizures in children and adults with developmental and epileptic encephalopathy. This research aims to understand how well it works for managing their condition.

Developmental and Epileptic Encephalopathies1-2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteNeurology

Hemoptysis Treatment: TXA vs. Terlipressin

We are studying whether inhaled tranexamic acid or terlipressin can help control coughing up blood in hospitalized patients. The goal is to see if these treatments work better than a placebo in managing this serious condition.

Coughing Up Blood (Hemoptysis)Confirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteInternal MedicinePulmonology

Cancer Pain Management: Paracetamol with Opioids

We are studying whether stopping paracetamol affects pain control in patients using strong opioids for cancer-related pain. We also want to see if this change impacts side effects and overall patient satisfaction.

Metastatic Cancer≤3 monthsConfirmation phase (III)≤5 visitsStandard MedicinesInternal MedicineOncology

Septic Shock: Ivabradine for Heart Rate Control

We are studying whether Ivabradine can help control heart rate and improve survival in patients with septic shock. This trial compares the medication to a placebo to assess its effectiveness.

Septic Shock>2 yearsConfirmation phase (III)Standard MedicinesCardiologyInfectious DiseasesInternal Medicine

Mitapivat for Children with Pyruvate Kinase Deficiency

We are studying whether Mitapivat can help increase hemoglobin levels in children with Pyruvate Kinase Deficiency who do not receive regular blood transfusions. This trial compares the treatment to a placebo to assess its effectiveness.

Pyruvate Kinase Deficiency Anemia>2 yearsConfirmation phase (III)>20 visitsPost-Trial Drug AccessStandard MedicinesPartially RemoteHematologyPediatrics

Infection Prevention in Joint Replacement: PREVENT-iT Study

We are studying whether different irrigation solutions and local vancomycin can lower the risk of infections after hip or knee joint replacement surgeries. This research aims to improve patient outcomes and reduce the need for additional surgeries.

Total Joint Replacement SurgeryConfirmation phase (III)Standard MedicinesInfectious DiseasesOrthopedics and Traumatology

Metoprolol for Heart Health in Duchenne Muscular Dystrophy

We are studying whether metoprolol can help prevent heart issues in boys aged 8-17 with Duchenne Muscular Dystrophy. This trial will compare its effects to a placebo alongside standard heart care.

Duchenne Muscular Dystrophy>2 yearsConfirmation phase (III)Post-Trial Drug AccessStandard MedicinesPartially RemoteCardiologyNeurology

Rituximab for Children with Nephrotic Syndrome

We are studying whether early treatment with rituximab helps children with idiopathic nephrotic syndrome stay in remission longer than those receiving a placebo. This trial aims to improve treatment strategies for this condition.

Nephrotic Syndrome>2 yearsConfirmation phase (III)11-15 visitsStandard MedicinesInternal MedicineNephrology

Marfan Syndrome: Valsartan for Aortic Health

We are studying whether valsartan can slow down aortic root dilatation in children and young adults with Marfan syndrome. The trial will measure changes in aortic size and related health outcomes.

Marfan SyndromeLoeys-Dietz SyndromeEhlers-Danlos Syndrome>2 yearsConfirmation phase (III)11-15 visitsStandard MedicinesPartially RemoteCardiologyInternal Medicine

Levosimendan Therapy for Low Ejection Fraction Takotsubo Syndrome

We are studying whether levosimendan can help improve heart function and reduce serious health risks in patients with Takotsubo syndrome. This trial compares the medication to a placebo to see if it makes a difference.

Takotsubo Syndrome1-2 yearsConfirmation phase (III)Standard MedicinesPartially RemoteCardiologyInternal Medicine

Heart Failure: Sertraline for Anxiety and Depression

We are studying whether sertraline can help reduce anxiety and depression symptoms in heart failure patients. The trial also looks at its effects on heart health and overall well-being.

Heart Failure with Preserved Ejection Fraction and Anxiety>2 yearsConfirmation phase (III)Investigational MedicinesCardiologyPsychiatry

Acute Ischemic Stroke: Mechanical Thrombectomy Study

We are studying whether adding a mechanical procedure to standard treatment helps patients with acute ischemic stroke due to large vessel blockage. The trial also examines safety and quality of life for participants.

Malignant Ischemic Stroke>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesInternal MedicineNeurology

Myelodysplastic Syndromes: Oral ASTX030 vs. Subcutaneous Azacitidine

We are studying a new oral treatment for patients with myelodysplastic syndromes, chronic myelomonocytic leukemia, or acute myeloid leukemia. The trial aims to evaluate its safety and how it compares to the standard subcutaneous treatment.

Chronic Myelomonocytic LeukaemiaAcute Myeloid LeukaemiaMyelodysplastic Syndrome>2 yearsConfirmation phase (III)11-15 visitsNo PlaceboStandard MedicinesHematology

Cerebral Adrenoleukodystrophy: Leriglitazone Study

We are studying whether leriglitazone can improve survival and slow disease progression in adult males with cerebral adrenoleukodystrophy. Participants will receive either the medication or a placebo to compare effects.

Adrenoleukodystrophy>2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteEndocrinologyNeurology

Exercise and Statin Use in Advanced Cancer Treatment

We are studying whether supervised exercise and atorvastatin can improve cancer treatment outcomes for patients with advanced breast, renal, ovarian, and prostate cancers. We also want to understand how these interventions affect patients' quality of life and experiences during treatment.

Metastatic Breast, Ovarian, Prostate, and Kidney Cancer≤3 monthsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementGynecology and ObstetricsOncologyUrology

Dupuytren's Contracture: Comparing Treatment Options

We are studying three different treatments for Dupuytren's contracture to see which one works best and is most cost-effective. This trial includes patients with mild to moderate cases and will track outcomes over several years.

Dupuytren's Contracture>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesDermatologyOrthopedics and Traumatology

Rabies Vaccine: Pain and Usability Study for Kids

We are exploring how different injection methods affect pain and anxiety in children aged 4 to 14 receiving a rabies vaccine. Parents will also share their observations about their child's experience.

Rabies Pre-Exposure Prophylaxis3-6 monthsConfirmation phase (III)Monitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesCost ReimbursementInfectious DiseasesPediatrics

Colorectal Surgery: Cefoxitin Administration Study

We are comparing two ways of giving cefoxitin to prevent infections after colorectal surgery. This study aims to find out if a continuous infusion is better than the standard method for reducing complications.

Colorectal Surgery>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesGastroenterologyInfectious DiseasesInternal MedicineOrthopedics and Traumatology

Eosinophilic Asthma: Benralizumab Treatment Study

We are studying how well benralizumab works and its safety for people with eosinophilic asthma who are not well-controlled on standard treatments. This trial compares it to increasing their current medication dose.

Eosinophilic Asthma1-2 yearsConfirmation phase (III)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteAllergologyPulmonology