Search Clinical Trials in the European Union

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121-140 of 552 trials

VAXXAIR TRIAL: Comparing Nasal and Injectable Flu Vaccines

We are studying how well a nasal flu vaccine works compared to an injectable one in building immunity. This research aims to find out which method produces a stronger immune response in the body.

Influenza>2 yearsMonitoring phase (IV)6-10 visitsInvestigational MedicinesCost ReimbursementInfectious DiseasesPulmonology

Chronic Spontaneous Urticaria: Omalizumab Treatment Intervals

We are studying whether adults with well-controlled chronic spontaneous urticaria can safely extend the time between omalizumab treatments while maintaining symptom control.

Chronic Spontaneous Urticaria6-12 monthsConfirmation phase (III)Monitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteAllergologyDermatology

Methylphenidate for Children with KBG Syndrome

We are studying how well methylphenidate helps children and adolescents with KBG syndrome manage attention and emotional symptoms. This trial also looks at family functioning and any side effects compared to typical ADHD treatments.

KBG Syndrome3-6 monthsMonitoring phase (IV)6-10 visitsInvestigational MedicinesCost ReimbursementPartially RemotePediatricsPsychiatry

Cystectomy Complications: Antifungal Treatment Study

We are testing whether a new antifungal medication can help reduce complications after radical cystectomy. This study compares the medication to a placebo to see if it makes a difference.

Fungal Infection3-6 monthsMonitoring phase (IV)Standard MedicinesInfectious DiseasesUrology

Herpes-Zoster Vaccine: Impact on Patients with Inflammatory Rheumatic Diseases

We are studying how anti-rheumatic treatments influence the effectiveness of the herpes-zoster vaccine in patients with inflammatory rheumatic diseases. This research aims to see if the vaccine provides adequate protection against shingles.

Inflammatory Rheumatic DiseasesVaccinationMonitoring phase (IV)Infectious DiseasesRheumatology

Heart Failure: Optimizing Drug Levels

We are studying how blood levels of heart failure medications affect patient health. This research may help improve treatment plans for individuals with heart failure.

Chronic Heart Failure with Reduced Ejection Fraction>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInternal Medicine

Obesity in Adolescents: Semaglutide Treatment Study

We are exploring whether a weekly injection of semaglutide can help adolescents with obesity lose weight more effectively than a placebo. This study also looks at the safety and overall health impacts of the treatment.

Obesity1-2 yearsMonitoring phase (IV)6-10 visitsInvestigational MedicinesPartially RemoteEndocrinologyPediatrics

Postoperative Pain Management After Cardiac Surgery: NSAIDs Study

We are investigating whether nonsteroidal anti-inflammatory drugs can help reduce pain after cardiac surgery. This study will also look at how these medications affect recovery and overall quality of life.

Postoperative Pain After Cardiac Surgery>2 yearsMonitoring phase (IV)Standard MedicinesCardiologyInternal Medicine

Plaque Psoriasis: Bimekizumab Study

We are exploring how bimekizumab affects gene expression in people with moderate to severe plaque psoriasis. The study also looks at the safety of this treatment for those with or without psoriatic arthritis.

Plaque PsoriasisPsoriatic Arthritis>2 yearsConfirmation phase (III)Monitoring phase (IV)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesDermatologyRheumatology

Early Rectal Cancer: FARE Trial with [68Ga]Ga-FAPI-46 PET/CT

We are studying a new imaging method to detect lymph node spread in early rectal cancer patients. This trial aims to see if it provides more accurate results than standard imaging techniques.

Rectal Cancer≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInfectious DiseasesInternal MedicineOtolaryngology

Liver Transplant: Single vs. Twice Daily Immunosuppressive Doses

We are studying whether a single daily dose of immunosuppressive medication is as effective as a twice-daily dose for liver transplant recipients. This trial also compares two different formulations of tacrolimus to see which works better.

Transplantation>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesHepatologyInternal Medicine

Schizophrenia: Intensified Treatment Study

We are investigating whether a six-week intensified medication plan helps individuals with schizophrenia who didn't respond to their first treatment. The study looks at changes in symptoms, functioning, and overall well-being compared to standard care.

Schizophrenia and Related Disorders≤3 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemotePsychiatry

Breast Cancer: Lower Dose of CDK 4/6-Inhibitors

We are studying whether a lower initial dose of a cancer medication is effective for older breast cancer patients compared to the standard dose. This trial aims to improve treatment outcomes and quality of life for vulnerable patients.

Advanced Breast Cancer>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteGastroenterologyGynecology and ObstetricsOncology

Rheumatoid Arthritis: Rituximab Tapering Strategies

We are studying different ways to reduce rituximab doses in patients with rheumatoid arthritis. The goal is to find the best method to lower disease impact and activity.

Rheumatoid Arthritis>2 yearsMonitoring phase (IV)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementInternal MedicineRheumatology

Fertility Treatments: Comparing Ovarian Stimulation Methods

We are studying two ovarian stimulation methods to see which one improves quality of life and satisfaction for women seeking fertility preservation or genetic testing. This research aims to help tailor treatments based on individual needs.

Subfertility3-6 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesEndocrinologyGynecology and Obstetrics

Chronic Kidney Disease: Teriparatide for Bone Health

We are studying whether teriparatide can improve bone metabolism in patients with chronic kidney disease and adynamic bone disorder. This trial compares the effects of treatment to no treatment at all.

Adynamic Bone Disorder>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesNephrologyOrthopedics and Traumatology

Staphylococcus Aureus Bacteraemia: Bensylpenicillin vs. Cloxacillin

We are comparing two antibiotics to see which one works better for patients with a specific bacterial infection. The study looks at treatment outcomes, relapse rates, and side effects.

Staphylococcus aureus Bacteraemia>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

Late Renal Graft Failure: Immunosuppression Study

We are comparing the effects of continuing versus stopping immunosuppression in patients with late renal graft failure. This study aims to see how these approaches impact health outcomes over two years.

Kidney Transplant>2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesInternal MedicineNephrology

Alectinib Dosing: Standard vs. Personalized Approach

We are comparing standard alectinib dosing to a personalized dosing method based on blood levels for patients with specific alectinib concentrations. The goal is to see if personalized dosing improves treatment outcomes and safety.

ALK Positive Non-Small Cell Lung Cancer1-2 yearsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesOncologyPulmonology

Influenza Vaccine Study for Adults Aged 65-79

We are comparing a high-dose flu vaccine to a standard-dose vaccine to see which one better reduces hospital visits for flu and pneumonia in older adults. This study aims to improve vaccine effectiveness for this age group.

Prevention of Influenza Infection in Older AdultsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious Diseases