Search Clinical Trials in the European Union

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161-180 of 3,900 trials

Multiple Myeloma: Iberdomide vs. Lenalidomide Maintenance Therapy

We are comparing two treatments for newly diagnosed multiple myeloma patients after stem cell transplant to see which one may help keep the disease from worsening. This study will also look at safety and quality of life for participants.

Newly Diagnosed Multiple Myeloma>2 yearsConfirmation phase (III)>20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementHematologyOncology

Prostate Cancer: Surgery with Darolutamide

We are studying whether adding darolutamide before and after surgery helps improve survival and quality of life for patients with high-risk or locally advanced prostate cancer.

Prostate Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesOncologyUrology

Pneumococcal Vaccine Response in Lymph Nodes

We are studying how the immune system reacts to the pneumococcal vaccine by analyzing lymph nodes. This research may help us understand the timing and types of immune cells involved in the vaccine response.

Healthy VolunteersEfficacy phase (II)No PlaceboInvestigational MedicinesAllergologyInfectious Diseases

Breast Cancer: Ribociclib with Hormone Therapy and Radiotherapy

We are studying the safety and effectiveness of Ribociclib combined with hormone therapy and radiotherapy for elderly patients with hormone-positive, HER2-negative breast cancer. This trial is for those newly diagnosed who are not ready for surgery.

Breast Cancer>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesEndocrinologyOncology

Osimertinib (TAGRISSO) Continuation Study

We are providing ongoing treatment with osimertinib for patients who have benefited from it in a previous study. The goal is to monitor safety and tolerability as they continue their treatment.

Non-small Cell Lung Cancer>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteOncology

Fertility Treatment: Progesterone Support in IUI

We are studying if adding progesterone support helps couples with unexplained infertility achieve higher live birth rates during intra-uterine insemination. We also want to see if this approach is cost-effective and safe.

Female Infertility and Subfertility1-2 yearsMonitoring phase (IV)Investigational MedicinesEndocrinologyGynecology and Obstetrics

Corticosteroid Treatment for Acute Myocarditis

We are studying whether intravenous corticosteroids can improve heart function in patients with acute myocarditis and mildly reduced heart performance. This trial compares corticosteroid therapy to standard treatment options.

Acute Myocarditis>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesCardiologyInternal Medicine

Dupuytren Contracture: Needle Procedure with Corticosteroid Injection

We are comparing a needle procedure with a corticosteroid injection to one with a saline injection for Dupuytren Contracture in the hand. This study aims to see if the corticosteroid helps reduce the chance of the condition returning.

Dupuytren's Contracture>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesDermatologyOrthopedics and Traumatology

High-Risk Prostate Cancer: THUNDER Trial

We are studying new diagnostic tracers and treatment options for men with high-risk prostate cancer. The goal is to see if these methods improve survival and quality of life compared to standard treatments.

Prostate Cancer1-2 yearsEfficacy phase (II)Confirmation phase (III)6-10 visitsInvestigational MedicinesOncologyUrology

Richter Syndrome: GLOfitamab with Chemotherapy

We are studying a new treatment combining GLOfitamab with standard chemotherapy for patients with Richter syndrome. The goal is to see if this combination improves treatment response and safety.

Richter's Syndrome1-2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesHematologyOncology

Triple-Negative Breast Cancer: Tiragolumab and Atezolizumab with Chemotherapy

We are studying a combination of two immunotherapy drugs with chemotherapy for patients with triple-negative breast cancer. This trial aims to evaluate the treatment's effectiveness and safety in both early and advanced stages of the disease.

Triple Negative Breast Cancer>2 yearsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesOncology

Advanced Solid Tumors: MK-1084 Treatment

We are testing a new drug, MK-1084, for patients with advanced solid tumors that have a KRAS mutation. This study aims to understand its safety and how it may help in treating these tumors.

Solid Tumor Cancer>2 yearsSafety phase (I)Oncology

Solid Tumors: AZD9592 Treatment Study

We are testing a new drug called AZD9592 for patients with solid tumors. The goal is to learn more about its safety and how it may help in treating cancer.

Metastatic Colorectal CancerRecurrent or Metastatic Head and Neck Squamous Cell CarcinomaLocally Advanced or Metastatic Non-Small Cell Lung Cancer>2 yearsSafety phase (I)Oncology

Serious Bacterial Infections in Children: Aztreonam-Avibactam Study

We are investigating a new treatment for serious gram-negative bacterial infections in children aged 9 months to under 18 years. The study compares this treatment to the best available therapy to assess safety and effectiveness.

Hospital-Acquired PneumoniaVentilator-Associated PneumoniaComplicated Gram-Negative Bacterial Infections≤3 monthsEfficacy phase (II)16-20 visitsNo PlaceboInvestigational MedicinesPartially RemoteInfectious DiseasesPediatrics

Atopic Dermatitis: Rocatinlimab Study

We are investigating the long-term safety and effectiveness of rocatinlimab for adults and adolescents with moderate-to-severe atopic dermatitis. The study compares the treatment's effects to a placebo in those who have previously responded to the medication.

Atopic DermatitisConfirmation phase (III)Investigational MedicinesCost ReimbursementAllergologyDermatology

Advanced Solid Tumors: ASP3082 Study

We are investigating a new treatment called ASP3082 for adults with advanced solid tumors. The goal is to learn more about its effects and safety in this patient group.

Solid Tumor>2 yearsSafety phase (I)Oncology

Graft-Versus-Host Disease: Anti-Lymphocyte Serum Study

We are studying how the anti-lymphocyte serum works in children and adults receiving stem cell transplants. This research aims to improve prevention strategies for graft-versus-host disease.

Stem Cell Transplant1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesHematologyPediatrics

Stroke Prevention in Kidney Disease: Apixaban Study

We are studying whether apixaban can safely reduce the risk of strokes in patients with chronic kidney disease stage 5 and atrial fibrillation. This trial will help us understand its effects compared to standard care.

Atrial Fibrillation with Chronic Kidney Disease Stage 5>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesCardiologyInternal MedicineNephrology

Ovarian Cancer: Mirvetuximab Soravtansine with Bevacizumab

We are studying a new treatment combining mirvetuximab soravtansine and bevacizumab for adults with recurrent ovarian cancer who have not progressed after chemotherapy. The goal is to see if this combination helps patients live longer without their cancer worsening.

Ovarian and Fallopian Tube Cancer>2 yearsConfirmation phase (III)Monitoring phase (IV)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementGynecology and ObstetricsOncology

Staphylococcal Joint Infection: Rifampicin vs. Clindamycin

We are studying whether a targeted antibiotic can effectively treat staphylococcal infections in joint prostheses compared to a traditional combination therapy. This trial also examines quality of life and any side effects experienced by participants.

Prosthetic Joint Infection1-2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesInfectious DiseasesOrthopedics and Traumatology